公开(公告)号：US4849512A

公开(公告)日：1989-07-18

申请号：US177483

申请日：1988-04-01

申请人： Minoru Tokizawa ,  Mari Otsuka ,  Kazuhiko Irinoda ,  Seiji Ishizeki ,  Fumio Ishii ,  Kenichi Kukita ,  Hideaki Matsuda ,  Tatsuhiko Katori

发明人： Minoru Tokizawa ,  Mari Otsuka ,  Kazuhiko Irinoda ,  Seiji Ishizeki ,  Fumio Ishii ,  Kenichi Kukita ,  Hideaki Matsuda ,  Tatsuhiko Katori

IPC分类号： C07H13/06 ,  A61K31/70 ,  A61K31/7024 ,  A61P35/00 ,  C07H9/04 ,  C07H13/04

CPC分类号： C07H13/04 ,  C07H9/04

摘要： Derivatives of 3-acylamino-3-deoxyallose represented by the following formula: ##STR1## wherein R.sup.1, R.sup.2, R.sup.3 and R.sup.4 may be hydrogen atoms, or R.sup.1 and R.sup.2, and R.sup.3 and R.sup.4 may be in combination an isopropylidene group, R.sup.5 represents a hydrogen atom or alkyl group, and R.sup.6 represents a hydrogen atom or acyl group, are disclosed. One of the typical compound 3-deoxy-3-(3-tetradecanoyloxytetradecanoylamino)-1,2:5,6-di-O-isopropylidene- .alpha.-D-allofuranose is prepared by reacting 3-tetradecanoyloxytetradecanoic acid and 3-amino-3-deoxy-1,2:5,6-di-O-isopropylidene-.alpha.-D-allofuranose in the presence of N,N'-dicyclohexylcarbodiimide, as a dehydrating agent. The compound has an excellent carcinostatic activity.

公开(公告)号：US5962509A

公开(公告)日：1999-10-05

申请号：US169989

申请日：1998-10-13

申请人： Fumio Ishii ,  Kinichi Mogi ,  Hiromichi Eto ,  Susumu Sato ,  Hideaki Matsuda

发明人： Fumio Ishii ,  Kinichi Mogi ,  Hiromichi Eto ,  Susumu Sato ,  Hideaki Matsuda

IPC分类号： A61K31/385 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07D339/06 ,  C07D339/02

CPC分类号： C07D339/06

摘要： Disclosed are dithiolylidene acetamide derivatives represented by the following formula: ##STR1## wherein R.sup.1 and R.sup.2 may be the same or different and each independently represent a hydrogen atom or an alkyl group, or salts thereof; and pharmaceuticals containing them as effective ingredients. The dithiolylidene acetamide derivatives and their salts show AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.

摘要翻译： 公开了由下式表示的二亚噻吩基乙酰胺衍生物：其中R1和R2可以相同或不同，各自独立地表示氢原子或烷基，或其盐; 和含有它们作为有效成分的药物。 二硫代亚乙酰胺衍生物及其盐显示AGE形成抑制作用，可用作糖尿病并发症的预防药物和治疗剂。

公开(公告)号：US6124347A

公开(公告)日：2000-09-26

申请号：US162451

申请日：1998-09-29

申请人： Fumio Ishii ,  Haruyoshi Honda ,  Fujiko Konno ,  Tomomi Okada ,  Terumitsu Kaihoh ,  Yoshihiro Nagao ,  Susumu Sato ,  Hideaki Matsuda

发明人： Fumio Ishii ,  Haruyoshi Honda ,  Fujiko Konno ,  Tomomi Okada ,  Terumitsu Kaihoh ,  Yoshihiro Nagao ,  Susumu Sato ,  Hideaki Matsuda

IPC分类号： A61K31/35 ,  A61K31/352 ,  A61P3/08 ,  A61P3/10 ,  A61P43/00 ,  C07D311/58 ,  C07D311/64 ,  A61K31/353 ,  C07D311/60

CPC分类号： C07D311/58

摘要： Disclosed are chromene derivatives represented by the following formula: ##STR1## wherein R.sup.1 s represent alkyl, alkoxy or like groups, R.sup.2 represents a hydrogen atom or an alkyl group, R.sup.3 represents a substituted or unsubstituted phenyl, naphthyl or heterocyclic group, and m stands for an integer of from 0 to 4, and their salts; and pharmaceuticals containing them as effective ingredients. The chromene derivatives and their salts show excellent AGE formation inhibitory action and are useful as preventives and therapeutics for diabetic complications.

摘要翻译： 公开了由下式表示的色烯衍生物：其中R 1表示烷基，烷氧基或类似基团，R 2表示氢原子或烷基，R 3表示取代或未取代的苯基，萘基或杂环基，m表示 0至4，及其盐; 和含有它们作为有效成分的药物。 色烯衍生物及其盐显示优异的AGE形成抑制作用，并且可用作糖尿病并发症的预防剂和治疗剂。

公开(公告)号：US4623580A

公开(公告)日：1986-11-18

申请号：US665789

申请日：1984-10-29

申请人： Kunihiro Koshizuka ,  Takao Abe ,  Shigehiro Kitamura ,  Masaki Nakamura ,  Yuji Hotta ,  Fumio Ishii

发明人： Kunihiro Koshizuka ,  Takao Abe ,  Shigehiro Kitamura ,  Masaki Nakamura ,  Yuji Hotta ,  Fumio Ishii

IPC分类号： B41M5/382 ,  B41M5/26 ,  B41M5/42

CPC分类号： B41M5/42 ,  B41M5/38228 ,  Y10S428/913 ,  Y10S428/914 ,  Y10T428/24901 ,  Y10T428/24917

摘要： A thermal transfer recording medium having a thermally transferable coloring agent containing layer coated on a support. The coloring agent containing layer is separated into at least two layers, one of which is the upper layer and the other of which is the lower layer, and the layer farthermost from the support is a thermally transferable layer containing substantially no coloring agent.

摘要翻译： 一种热转印记录介质，其具有涂覆在载体上的可热转印的着色剂层。 含着色剂层分成至少两层，其中一层是上层，另一层是下层，最远离载体的层是基本上不含着色剂的可热转移层。

公开(公告)号：US4994361A

公开(公告)日：1991-02-19

申请号：US441302

申请日：1989-11-27

申请人： Atsushi Tomotake ,  Shuji Kida ,  Mayumi Tomotake ,  Fumio Ishii

发明人： Atsushi Tomotake ,  Shuji Kida ,  Mayumi Tomotake ,  Fumio Ishii

IPC分类号： G03C7/36 ,  C07C235/80 ,  C07C237/42 ,  C07C237/44 ,  C07C255/54 ,  G03C7/305

CPC分类号： C07C255/54 ,  C07C235/80 ,  C07C237/42 ,  C07C237/44 ,  G03C7/30535

摘要： A silver halide color photographic light-sensitive material is disclosed in which a novel yellow coupler represented by the following Formula I is contained. ##STR1## wherein R.sub.1 is a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group; R.sub.2 and R.sub.3 are each a hydrogen atom, a substituted or unsubstituted alkyl group or a substituted or unsubstituted aryl group or a substituted or unsubstituted heterocyclic group; X is a hydrogen atom, a halogen atom, an alkoxy group or an alkylamino group; Y, B.sub.1 and B.sub.2 are each a substituent; and m and n are each an integer of zero to 3.

公开(公告)号：US4977063A

公开(公告)日：1990-12-11

申请号：US317719

申请日：1989-03-02

申请人： Yasushi Usagawa ,  Fumio Ishii

发明人： Yasushi Usagawa ,  Fumio Ishii

IPC分类号： C07C243/28 ,  C07C255/66 ,  C07C259/06 ,  C07C281/06 ,  C07C323/60 ,  C07C337/06 ,  C07D211/56 ,  C07D211/58 ,  C07D213/70 ,  C07D213/77 ,  C07D239/38 ,  C07D277/82 ,  C07D295/28 ,  C07D307/20 ,  C07D307/22 ,  C07D307/66 ,  C07D333/66 ,  C07D401/12 ,  C07D403/12 ,  G03C1/06

CPC分类号： C07D213/70 ,  C07C243/28 ,  C07C255/66 ,  C07C259/06 ,  C07C281/06 ,  C07C323/60 ,  C07C337/06 ,  C07D211/56 ,  C07D211/58 ,  C07D213/77 ,  C07D239/38 ,  C07D277/82 ,  C07D295/32 ,  C07D307/20 ,  C07D307/22 ,  C07D307/66 ,  C07D333/66 ,  C07D401/12 ,  C07D403/12 ,  G03C1/061

摘要： A silver halide photographic light-sensitive material is disclosed, which is inhibited in formation of pepper spot in a halftone image and capable of making extremely high contrast image thereon. The light-sensitive material contains a compound represented by the following formula: ##STR1## wherein A.sub.1 and A.sub.2 are each an arylene group or a divalent heterocyclic group; L is a linking group;z is a formyl group, an acyl group, a sulfonyl group, a carbamoyl group, a sulfamoyl group, an alkoxycarbonyl group, a thioacyl group or a ##STR2## group; X is --NR.sub.6 R.sub.7 or --OR.sub.8, in which R.sub.6 and R.sub.7 are each a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, a heterocyclic group, a hydroxy group, an alkoxy group, an alkenylkoxy group, an alkynyloxy group, an aryloxy group, or a heterocyclic oxy group, and R.sub.8 is a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group or a heterocyclic group; n is 1 or 2; m is 0 or 1; R.sub.1 and R.sub.2 are each a hydrogen atom, an alkyl group, an alkenyl group, an alkynyl group, an aryl group, a heterocyclic group or an amino group, provided that when n is 1, at least one of the R.sub.1 and R.sub.2 is an amino group; R.sub.3 is a hydrogen atom or an alkyl group; and R.sub.4 and R.sub.5 are each a hydrogen atom or a substituent.

公开(公告)号：US4394315A

公开(公告)日：1983-07-19

申请号：US229061

申请日：1981-01-28

申请人： Fumio Ishii ,  Kenichi Kishi

发明人： Fumio Ishii ,  Kenichi Kishi

IPC分类号： C07C50/04 ,  C07C45/00 ,  C07C46/06 ,  C07C50/02 ,  C07C50/06 ,  C07C50/08 ,  C07C50/10 ,  C07C67/00 ,  C07C50/12 ,  C07C50/18

CPC分类号： C07C46/06 ,  C07C50/02 ,  C07C50/06

摘要： A method for synthesizing p- or o-benzoquinone derivatives represented by formula III or IV ##STR1## by oxidizing, with an aqueous hypohalite solution having a pH of from 8 to 10, a p- or o-hydroquinone derivative represented by formula I or II ##STR2## Oxidation is conducted at a temperature between -20.degree. C. and 35.degree. C., in the presence of a quaternary ammonium salt phase transfer catalyst.

摘要翻译： 用式III或IV表示的对 - 或邻 - 苯醌衍生物的方法通过用pH为8至10的次氢氯酸盐溶液氧化，由式I表示的对 - 或邻 - 氢醌衍生物或 II。在季铵盐相转移催化剂的存在下，在-20℃至35℃的温度下进行氧化。

公开(公告)号：US06958353B2

公开(公告)日：2005-10-25

申请号：US10258610

申请日：2001-06-08

申请人： Fujiko Konno ,  Yoshihiro Nagao ,  Kazuo Isomae ,  Mari Ohtsuka ,  Yoshiyuki Takahashi ,  Fumio Ishii ,  Hiroyuki Hirota ,  Sunao Takeda ,  Noriyuki Kawamoto ,  Haruyoshi Honda ,  Susumu Sato

发明人： Fujiko Konno ,  Yoshihiro Nagao ,  Kazuo Isomae ,  Mari Ohtsuka ,  Yoshiyuki Takahashi ,  Fumio Ishii ,  Hiroyuki Hirota ,  Sunao Takeda ,  Noriyuki Kawamoto ,  Haruyoshi Honda ,  Susumu Sato

IPC分类号： A61P19/02 ,  A61P19/10 ,  A61P29/00 ,  A61P43/00 ,  C07D233/22 ,  C07D233/60 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14 ,  C07D521/00 ,  A61K31/4178 ,  A61K31/444

CPC分类号： C07D401/14 ,  C07D231/12 ,  C07D233/22 ,  C07D233/56 ,  C07D249/08 ,  C07D401/12 ,  C07D403/12 ,  C07D405/14 ,  C07D409/14

摘要： The invention is directed to an imidazole derivative represented by formula (1): wherein each of R1 and R2 represents an aryl group, a heteroaryl group, etc.; each of A, X1, and X2 represents N or CH; each of Y and Z represents O, S, etc.; each of R3, R4, and R5 represents a hydrogen atom, an alkyl group, etc.; m is a number of 1 to 4; and n is a number of 0 to 4, or a salt thereof. The invention is also directed to a drug containing the derivative or the salt as an active ingredient. These compounds exert excellent effects of inhibiting production of NO and IL-6 and are useful for preventing or treating diseases induced by overproduction of NO and IL-6.

摘要翻译： 本发明涉及由式（1）表示的咪唑衍生物：其中R 1和R 2各自表示芳基，杂芳基等; A，X 1和X 2各自表示N或CH; Y和Z各自表示O，S等; R 3，R 4和R 5各自表示氢原子，烷基等; m是1到4的数字; n为0〜4的数，或其盐。 本发明还涉及含有衍生物或盐作为活性成分的药物。 这些化合物具有抑制NO和IL-6产生的优异效果，可用于预防或治疗由过量产生NO和IL-6引起的疾病。

公开(公告)号：US06242609B1

公开(公告)日：2001-06-05

申请号：US09287501

申请日：1999-04-07

申请人： Fumio Ishii

发明人： Fumio Ishii

IPC分类号： C07D24916

CPC分类号： C07D207/333 ,  C07D209/08 ,  C07D231/52 ,  C07D487/04

摘要： A method for manufacturing a color coupler used in a silver halide photographic light-sensitive material using an ammonium trihalide. Said method for manufacturing the color coupler comprising the following step: a step for halogenating a coupling position of a four equivalent coupler using a halogenating agent, wherein said halogenating agent is said ammonium trihalide.

摘要翻译： 一种制造使用三卤化铵的卤化银照相感光材料中的着色成色剂的方法。用于制造彩色成色剂的方法包括以下步骤：使用卤化剂卤化四价成色剂的偶联位置的步骤 其中所述卤化剂是所述三卤化铵。

公开(公告)号：US5922767A

公开(公告)日：1999-07-13

申请号：US946098

申请日：1997-10-07

申请人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

发明人： Yoshihiko Kanamaru ,  Hiroyuki Hirota ,  Akihiro Shibata ,  Teruo Komoto ,  Hiroyuki Naito ,  Koichi Tachibana ,  Mari Ohtsuka ,  Fumio Ishii ,  Susumu Sato

IPC分类号： C07C275/28 ,  C07D213/30 ,  C07D307/42 ,  C07D333/16 ,  A61K31/17 ,  C07C275/06

CPC分类号： C07D213/30 ,  C07C275/28 ,  C07D307/42 ,  C07D333/16

摘要： Disclosed herein are substituted benzylurea derivatives represented by the following general formula (1): ##STR1## wherein R.sup.1 and R.sup.2 are independently H, a halogen atom, or an alkyl or alkoxyl group, R.sup.3 is a phenyl or heterocyclic group which may be substituted, n is an integer of 1-6, and R.sup.4 is a phenyl group which may be substituted, or salts thereof, and medicines comprising such a derivative as an active ingredient. The derivatives or salts thereof strongly inhibit only ACAT in macrophages and are hence useful as prophylactic and therapeutic agents for arteriosclerosis.

摘要翻译： 本文公开了由以下通式（1）表示的取代的苄基脲衍生物：其中R 1和R 2独立地为H，卤素原子或烷基或烷氧基，R 3为可被取代的苯基或杂环基，n为 1-6的整数，R4是可被取代的苯基或其盐，以及包含这种衍生物作为活性成分的药物。 其衍生物或盐在巨噬细胞中仅强烈地抑制ACAT，因此可用作动脉硬化的预防和治疗剂。