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    Pyrazolopyrimidine derivative
    5.
    发明授权
    Pyrazolopyrimidine derivative 有权
    吡唑并嘧啶衍生物

    公开(公告)号：US08158638B2

    公开(公告)日：2012-04-17

    申请号：US12442094

    申请日：2007-09-14

    申请人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

    发明人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

    IPC分类号： A61K31/505 ,  A61K31/415 ,  C07D491/00 ,  C07D487/02

    CPC分类号： C07D495/16 ,  C07D495/20 ,  C07D495/22 ,  C07D498/22

    摘要： Problem to be SolvedTo provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity.SolutionThe present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

    摘要翻译： 要解决的问题提供抑制HSP90的作用的新型化合物，特别是抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性的新化合物。 溶液本发明提供了具有抑制HSP90的ATP酶活性且具有抗肿瘤活性的各种取代基的式（1）表示的吡唑并嘧啶化合物，包含由式（1）表示的化合物的HSP90抑制剂，包含化合物 （1）代表的抗癌剂，包含由式（1）表示的化合物的抗癌剂，包含式（1）表示的化合物的药物组合物和使用式（1）表示的化合物治疗癌症的方法 ）。

    PYRAZOLOPYRIMIDINE DERIVATIVE
    6.
    发明申请
    PYRAZOLOPYRIMIDINE DERIVATIVE 有权
    吡唑并嘧啶衍生物

    公开(公告)号：US20100113410A1

    公开(公告)日：2010-05-06

    申请号：US12442094

    申请日：2007-09-14

    申请人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

    发明人： Satoru Ohsuki ,  Atsushi Tengeiji ,  Masahiro Ikeda ,  Yoshihiro Shibata ,  Chikahiro Nagata ,  Takashi Shimada

    IPC分类号： A61K31/519 ,  C07D495/16 ,  C07D487/04 ,  C07D495/20 ,  A61K31/5377 ,  A61P35/00

    CPC分类号： C07D495/16 ,  C07D495/20 ,  C07D495/22 ,  C07D498/22

    摘要： Problem to be Solved To provide a novel compound inhibiting the effect of HSP90, in particular a novel compound inhibiting the function of HSP90 as a chaperone protein and having antitumor activity. Solution The present invention provides a pyrazolopyrimidine compound represented by the formula (1) having various substituents which inhibits the ATPase activity of HSP90 and which has antitumor activity, an HSP90 inhibitor comprising the compound represented by the formula (1), a medicament comprising the compound represented by the formula (1), an anticancer agent comprising the compound represented by the formula (1), a pharmaceutical composition comprising the compound represented by the formula (1) and a method for treating cancer using the compound represented by the formula (1).

    摘要翻译： 要解决的问题提供抑制HSP90的作用的新型化合物，特别是抑制HSP90作为伴侣蛋白的功能并具有抗肿瘤活性的新化合物。 溶液本发明提供了具有抑制HSP90的ATP酶活性且具有抗肿瘤活性的各种取代基的式（1）表示的吡唑并嘧啶化合物，包含由式（1）表示的化合物的HSP90抑制剂，包含化合物 （1）代表的抗癌剂，包含由式（1）表示的化合物的抗癌剂，包含式（1）表示的化合物的药物组合物和使用式（1）表示的化合物治疗癌症的方法 ）。

    Optical telephone using optical modulator
    7.
    发明授权
    Optical telephone using optical modulator 失效
    光电话使用光调制器

    公开(公告)号：US5357362A

    公开(公告)日：1994-10-18

    申请号：US59467

    申请日：1993-05-07

    申请人： Yuji Azuma ,  Yoshihiro Shibata ,  Shinji Tamura ,  Nobuo Kuwaki ,  Nobuhiro Ikawa ,  Akira Fukuda ,  Akio Kuwahara

    发明人： Yuji Azuma ,  Yoshihiro Shibata ,  Shinji Tamura ,  Nobuo Kuwaki ,  Nobuhiro Ikawa ,  Akira Fukuda ,  Akio Kuwahara

    IPC分类号： G02B6/28 ,  G02B26/02 ,  H04B10/155 ,  H04B10/213 ,  H04B10/12 ,  G02B6/26 ,  H04B10/04

    CPC分类号： H04B10/505 ,  G02B26/02 ,  G02B6/2852

    摘要： An optical modulation method operable in an optical transmission path using an optical fiber, wherein an optical fiber bending region is formed by bending a portion of the optical fiber into a U shape having a predetermined bending width. A bending width set point is set in correspondence with a predetermined inclined portion of a characteristic curve representing a dependency ratio of insertion loss of light propagating in said optical fiber bending region relative to the bending width thereof, said predetermined inclined portion of said characteristic curve being located between a predetermined maximum and minimum portion thereof. Intensity modulation of light propagating in the optical fiber is performed using a signal to be transmitted by adjusting the bending width of the optical fiber bending region in correspondence with the signal to be transmitted with reference to the bending width set point as a center. An optical telephone uses an optical modulator including an optical fiber having a U-shaped bending region and a transducer for vibrating one straight portion of the optical fiber.

    摘要翻译： 一种光学调制方法，其在使用光纤的光传输路径中可操作，其中通过将所述光纤的一部分弯曲成具有预定弯曲宽度的U形形成光纤弯曲区域。 弯曲宽度设定点对应于表示在所述光纤弯曲区域中传播的光的插入损耗相对于其弯曲宽度的依赖比的特性曲线的预定倾斜部分，所述特征曲线的所述预定倾斜部分为 位于其预定的最大和最小部分之间。 通过以相对于弯曲宽度设定点为中心的要发送的信号调整光纤弯曲区域的弯曲宽度，通过使用要发送的信号来进行在光纤中传播的光的强度调制。 光电话机使用包括具有U形弯曲区域的光纤的光学调制器和用于振动光纤的一个直线部分的换能器。

    Video tape recorder and/or reproducer
    8.
    发明授权
    Video tape recorder and/or reproducer 失效
    录像机和/或再现器

    公开(公告)号：US5180117A

    公开(公告)日：1993-01-19

    申请号：US537640

    申请日：1990-06-14

    申请人： Nobuo Katohno ,  Yoshihiro Shibata

    发明人： Nobuo Katohno ,  Yoshihiro Shibata

    IPC分类号： G11B15/18 ,  G11B15/29 ,  G11B15/43 ,  G11B15/44

    CPC分类号： G11B15/43 ,  G11B15/29 ,  G11B15/444

    摘要： In a video tape recorder and/or reproducer, the power of a capstan motor for driving a magnetic tape is utilized as the power for driving reels in a cassette. In order to facilitate controlling the tension of the magnetic tape at the time of a change in the travelling direction of the tape in an intermittent tape travel mode, it is possible to drive a feed-side reel without turning OFF a back tension servo mechanism which applies back tension to the feed-side reel. In this state, the change in the travelling direction of the magnetic tape is performed by only controlling the direction of rotation of the capstan motor.

    摘要翻译： 在磁带录像机和/或再生器中，用于驱动磁带的主导轴马达的功率被用作驱动盒中的卷轴的功率。 为了便于在间歇磁带行驶模式下在磁带的行进方向改变时控制磁带的张力，可以驱动馈送侧卷轴而不关闭背张力伺服机构， 向进料侧卷轴施加反向张力。 在这种状态下，通过仅控制主导轴马达的旋转方向来进行磁带的行进方向的变化。

    NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS
    9.
    发明申请
    NOVEL SPIROCHROMANONE CARBOXYLIC ACIDS 有权
    新型螺环酮羧酸

    公开(公告)号：US20110077262A1

    公开(公告)日：2011-03-31

    申请号：US12997263

    申请日：2009-06-29

    申请人： Hideki Jona ,  Yoshihiro Shibata ,  Takeru Yamakawa

    发明人： Hideki Jona ,  Yoshihiro Shibata ,  Takeru Yamakawa

    IPC分类号： A61K31/438 ,  C07D491/107 ,  A61P3/00 ,  A61P3/04 ,  A61P3/10 ,  A61P31/00

    CPC分类号： C07D491/107 ,  A61K31/438 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709

    摘要： The invention relates to a compound of a general formula (I): wherein A represents a linking group; Ar1 represents a group formed from an aromatic ring; R1 and R2 each independently represent a hydrogen atom, a halogen atom, a cyano group, a C2-C6 alkenyl group, a C1-C6 alkoxy group, a halo-C1-C6 alkoxy group, a cyclo-C3-C6 alkyloxy group, a C2-C7 alkanoyl group, a halo-C2-C7 alkanoyl group, a C2-C7 alkoxycarbonyl group, a halo-C2-C7 alkoxycarbonyl group, a cyclo-C3-C6 alkyloxycarbonyl group, an aralkyloxycarbonyl group, a carbamoyl-C1-C6 alkoxy group, a carboxy-C2-C6 alkenyl group, or a group of -Q1-N(Ra)-Q2-Rb; a C1-C6 alkyl group optionally having substituent(s); an aryl or heterocyclic group optionally having substituent(s); or a C1-C6 alkyl group or a C2-C6 alkenyl group having the aryl or heterocyclic group; T and U each independently represent a nitrogen atom or a methine group; and V represents an oxygen atom, a sulfur atom or an imino group. The compound of the invention is useful as therapeutical agents for various ACC-related diseases.

    摘要翻译： 本发明涉及通式（I）的化合物：其中A表示连接基团; Ar 1表示由芳香环形成的基团; R 1和R 2各自独立地表示氢原子，卤素原子，氰基，C 2 -C 6烯基，C 1 -C 6烷氧基，卤代-C 1 -C 6烷氧基，环-C 3 -C 6烷氧基， C2-C7烷酰基，卤代-C2-C7烷酰基，C2-C7烷氧基羰基，卤代-C2-C7烷氧基羰基，环-C3-C6烷氧基羰基，芳烷氧基羰基，氨基甲酰基C1- C6烷氧基，羧基-C2-C6烯基或-Q1-N（Ra）-Q2-Rb的基团; 任选具有取代基的C1-C6烷基; 任选具有取代基的芳基或杂环基; 或具有芳基或杂环基的C 1 -C 6烷基或C 2 -C 6烯基; T和U各自独立地表示氮原子或次甲基; V表示氧原子，硫原子或亚氨基。 本发明的化合物可用作各种ACC相关疾病的治疗剂。

    Optical modulation method operable in an optical transmission path and an optical modulator using the optical modulation method
    10.
    发明授权
    Optical modulation method operable in an optical transmission path and an optical modulator using the optical modulation method 失效
    在光传输路径中可操作的光调制方法和使用光调制方法的光调制器

    公开(公告)号：US5259045A

    公开(公告)日：1993-11-02

    申请号：US831562

    申请日：1992-02-05

    申请人： Yuji Azuma ,  Yoshihiro Shibata ,  Shinji Tamura ,  Nobuo Kuwaki ,  Nobuhiro Ikawa ,  Akira Fukuda ,  Akio Kuwahara

    发明人： Yuji Azuma ,  Yoshihiro Shibata ,  Shinji Tamura ,  Nobuo Kuwaki ,  Nobuhiro Ikawa ,  Akira Fukuda ,  Akio Kuwahara

    IPC分类号： G02B6/28 ,  G02B26/02 ,  H04B10/155 ,  H04B10/213 ,  G02B6/26

    CPC分类号： H04B10/505 ,  G02B26/02 ,  G02B6/2852

    摘要： An optical modulation method operable in an optical transmission path using an optical fiber, wherein an optical fiber bending region is formed by bending a portion of the optical fiber into a U shape having a predetermined bending width. A bending width set point is set in correspondence with a predetermined inclined portion of a characteristic curve representing a dependency ratio of insertion loss of light propagating in said optical fiber bending region relative to the bending width thereof, said predetermined inclined portion of said characteristic curve being located between a predetermined maximum and minimum portion thereof. Intensity modulation of light propagating in the optical fiber is performed using a signal to be transmitted by adjusting the bending width of the optical fiber bending region in correspondence with the signal to be transmitted with reference to the bending width set point as a center.

    摘要翻译： 一种光学调制方法，其在使用光纤的光传输路径中可操作，其中通过将所述光纤的一部分弯曲成具有预定弯曲宽度的U形形成光纤弯曲区域。 弯曲宽度设定点对应于表示在所述光纤弯曲区域中传播的光的插入损耗相对于其弯曲宽度的依赖比的特性曲线的预定倾斜部分，所述特征曲线的所述预定倾斜部分为 位于其预定的最大和最小部分之间。 通过以相对于弯曲宽度设定点为中心的要发送的信号调整光纤弯曲区域的弯曲宽度，通过使用要发送的信号来进行在光纤中传播的光的强度调制。