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公开(公告)号：US20160376352A1
公开(公告)日：2016-12-29
申请号：US15189711
申请日：2016-06-22
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/92
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
摘要翻译： 本发明提供人源化抗人Tau（pS422）抗体及其使用方法。
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公开(公告)号：US20180079804A1
公开(公告)日：2018-03-22
申请号：US15832176
申请日：2017-12-05
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
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公开(公告)号：US09862763B2
公开(公告)日：2018-01-09
申请号：US15189711
申请日：2016-06-22
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18 , C07K14/47 , A61K39/395 , A61K39/00
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/92
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
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公开(公告)号：US20230265177A1
公开(公告)日：2023-08-24
申请号：US18091056
申请日：2022-12-29
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K2317/24 , C07K2317/34 , C07K2317/92 , A61K2039/505
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
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公开(公告)号：US10364292B2
公开(公告)日：2019-07-30
申请号：US15203057
申请日：2016-07-06
发明人： Petra Rueger , Georg Tiefenthaler , Ekkehard Moessner , Jens Niewoehner , Adrian Hugenmatter , Cuiying Shao , Francesca Ros , Gang Xu
摘要： Herein is reported a blood brain barrier shuttle module comprising a brain effector entity, a linker and one monovalent binding entity which binds to a blood brain barrier receptor, wherein the linker couples the effector entity to the monovalent binding entity which binds to the blood brain barrier receptor wherein the monovalent binding entity does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03).
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公开(公告)号：US20210139571A1
公开(公告)日：2021-05-13
申请号：US17023963
申请日：2020-09-17
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
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公开(公告)号：US11572404B2
公开(公告)日：2023-02-07
申请号：US17023963
申请日：2020-09-17
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18 , C07K14/47 , A61K39/395 , A61K39/00
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
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公开(公告)号：US10822402B2
公开(公告)日：2020-11-03
申请号：US15832176
申请日：2017-12-05
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18 , C07K14/47 , A61K39/395 , A61K39/00
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
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