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公开(公告)号：US20230287118A1
公开(公告)日：2023-09-14
申请号：US18046365
申请日：2022-10-13
发明人： Oliver AST , Marina Bacac , Sabine Imhof-Jung , Christiane Neumann , Christian Klein , Stefan Klostermann , Michael Molhoj , Joerg Thomas Regula , Wolfgang Schaefer , Pablo Umana
CPC分类号： C07K16/2809 , C07K16/2887 , C07K16/2878 , C07K16/3053 , C07K16/32 , C07K2317/31 , C07K2317/55 , C07K2317/66 , C07K2317/21 , C07K2317/526 , C07K2317/732 , C07K2317/14 , C07K2317/94 , C07K2317/33 , C07K2317/92 , C07K2317/51 , C07K2317/515 , C07K2317/64 , C07K2317/54
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20220073599A1
公开(公告)日：2022-03-10
申请号：US17466276
申请日：2021-09-03
发明人： Roland Beckmann , Sebastian Fenn , Guido Hartmann , Sabine Imhof-Jung , Kristian Hobolt-Jensen , Joerg Moelleken , Michael Molhoj , Christian Schantz , Janina Speck , Christoph Ullmer , Barbara Weiser
摘要： The present invention relates to anti-VEGF-A/anti-ANG2 antibodies, e.g. in the form of a bispecific Fab fragment, and methods of using the same.
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公开(公告)号：US10730938B2
公开(公告)日：2020-08-04
申请号：US15590176
申请日：2017-05-09
发明人： Marc Bedoucha , Sebastian Breuer , Stefan Dengl , Christian Gassner , Guy Georges , Sabine Gruener , Guido Hartmann , Peter Michael Huelsmann , Hubert Kettenberger , Joerg Moelleken , Michael Molhoj , Olaf Mundigl , Joerg Thomas Regula , Ralf Schumacher , Barbara Weiser
摘要： Herein are reported novel bispecific antibodies that specifically bind to two different antigens selected from the group consisting of human ANG2, human VEGF, human IL-1beta and human PDGF-B.
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公开(公告)号：US20180222992A1
公开(公告)日：2018-08-09
申请号：US15941655
申请日：2018-03-30
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , A61K2039/505 , A61P25/28 , C07K16/18 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64
摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20170247441A1
公开(公告)日：2017-08-31
申请号：US15591600
申请日：2017-05-10
发明人： Stefan Dengl , Guy Georges , Peter Michael Huelsmann , Hubert Kettenberger , Joerg Moelleken , Michael Molhoj , Joerg Thomas Regula
IPC分类号： C07K16/22 , A61K39/395
摘要： Herein are reported anti-ANG2 antibodies. A specific anti-ANG2 antibody comprises (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 29, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 30, and (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 32.
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公开(公告)号：US20170115304A1
公开(公告)日：2017-04-27
申请号：US15278242
申请日：2016-09-28
CPC分类号： G01N33/6848 , C12Q1/37 , G01N33/6854 , G01N33/6857
摘要： Use of a limited digestion with a proteolytic enzyme of a multispecific antibody for the analysis of the multispecific antibody's light chain pairing.
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公开(公告)号：US20160376352A1
公开(公告)日：2016-12-29
申请号：US15189711
申请日：2016-06-22
发明人： Stefan Dengl , Thomas Emrich , Guy Georges , Ulrich Goepfert , Fiona Grueninger , Adrian Hugenmatter , Anton Jochner , Hubert Kettenberger , Joerg Moelleken , Ekkehard Moessner , Olaf Mundigl , Jens Niewoehner , Tilman Schlothauer , Michael Molhoj , Kevin Brady
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , A61K2039/505 , C07K2317/24 , C07K2317/31 , C07K2317/34 , C07K2317/92
摘要： The invention provides humanized anti-human Tau(pS422) antibodies and methods of using the same.
摘要翻译： 本发明提供人源化抗人Tau（pS422）抗体及其使用方法。
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公开(公告)号：US12030952B2
公开(公告)日：2024-07-09
申请号：US17664609
申请日：2022-05-23
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20230365702A1
公开(公告)日：2023-11-16
申请号：US18132486
申请日：2023-04-10
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , C07K16/18 , C07K16/468 , A61P25/28 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/64 , A61K2039/505
摘要： Herein are provided bispecific anti-human A-beta/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US11787868B2
公开(公告)日：2023-10-17
申请号：US17130477
申请日：2020-12-22
发明人： Harald Duerr , Sebastian Fenn , Ulrich Goepfert , Sabine Imhof-Jung , Christian Klein , Laurent Lariviere , Michael Molhoj , Joerg Thomas Regula , Petra Rueger , Wolfgang Schaefer
CPC分类号： C07K16/2881 , A61P25/28 , C07K16/18 , C07K16/468 , A61K2039/505 , C07K2317/31 , C07K2317/51 , C07K2317/515 , C07K2317/52 , C07K2317/522 , C07K2317/55 , C07K2317/56 , C07K2317/64
摘要： Herein are provided bispecific anti-human A-betalhuman transferrin receptor antibodies and methods of using the same.
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