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公开(公告)号：US20200071411A1
公开(公告)日：2020-03-05
申请号：US16684258
申请日：2019-11-14
发明人： Maria AMANN , Peter BRUENKER , Christina CLAUS , Claudia FERRARA KOLLER , Sandra GRAU-RICHARDS , Ralf HOSSE , Christian KLEIN , Viktor LEVITSKI , Pablo UMANA
摘要： The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20210009656A1
公开(公告)日：2021-01-14
申请号：US17030251
申请日：2020-09-23
发明人： Peter BRUENKER , Claudia Ferrara KOLLER , Sandra GRAU-RICHARDS , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Maria AMANN , Christina CLAUS , Wei XU
IPC分类号： C07K14/705 , C07K16/28 , C07K14/715 , A61K47/68 , A61K39/395 , C07K16/14 , C07K16/24 , C07K16/30 , C07K16/40
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) one Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain, wherein the TNF family ligand trimer-containing antigen binding molecule is monovalent for the binding to the target cell antigen.
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公开(公告)号：US20190211113A1
公开(公告)日：2019-07-11
申请号：US16218266
申请日：2018-12-12
发明人： Maria AMANN , Peter BRUENKER , Christina CLAUS , Claudia FERRARA KOLLER , Sandra GRAU-RICHARDS , Ralf HOSSE , Christian KLEIN , Viktor LEVITSKI , Samuel MOSER , Pablo UMANA
CPC分类号： C07K16/40 , C07K16/2875 , C07K16/2878 , C07K16/30 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/35 , C07K2317/41 , C07K2317/52 , C07K2317/522 , C07K2317/524 , C07K2317/526 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/66 , C07K2317/71 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , C07K2319/30 , C07K2319/32
摘要： The invention relates to novel bispecific antigen binding molecules, comprising (a) four moities capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20220073646A1
公开(公告)日：2022-03-10
申请号：US17347257
申请日：2021-06-14
发明人： Maria AMANN , Peter BRUENKER , Christina CLAUS , Claudia FERRARA KOLLER , Sandra GRAU-RICHARDS , Ralf HOSSE , Christian KLEIN , Viktor LEVITSKI , Samuel MOSER , Pablo UMANA
摘要： The invention relates to novel bispecific antigen binding molecules, comprising (a) four moieties capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20210024610A1
公开(公告)日：2021-01-28
申请号：US17066711
申请日：2020-10-09
发明人： Claudia FERRARA KOLLER , Teemu Tapani JUNTTILA , Christian KLEIN , Pablo UMANA , Christina CLAUS
IPC分类号： C07K14/705 , C07K16/32 , A61K38/17 , A61K39/395 , C07K16/28 , A61P35/00
摘要： The invention relates to Her2 targeting 4-1BB agonists, in particular 4-1BBL trimer-containing antigen binding molecules comprising at least one antigen binding domain capable of specific binding to Her2 and their use in the treatment of cancer as well as their use in combination with T-cell activating anti-CD3 bispecific antibodies.
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公开(公告)号：US20230045262A1
公开(公告)日：2023-02-09
申请号：US17819867
申请日：2022-08-15
摘要： The invention relates to new bispecific antigen binding molecules, comprising at least one antigen binding domain capable of specific binding to 4-1BB, at least one moiety capable of specific binding to a target cell antigen, and a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20220025069A1
公开(公告)日：2022-01-27
申请号：US17498515
申请日：2021-10-11
IPC分类号： C07K16/40 , C07K14/475 , C07K16/46 , C07K16/32
摘要： The invention relates to bispecific antigen binding molecule capable of bivalent binding to 4-1BB and monovalent binding to a target cell antigen comprising two lipocalin muteins capable of specific binding to 4-1BB and their use in the treatment of cancer or infectious diseases.
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公开(公告)号：US20180356411A1
公开(公告)日：2018-12-13
申请号：US15745666
申请日：2016-06-21
IPC分类号： G01N33/542
CPC分类号： G01N33/542 , G01N33/5008 , G01N33/5023 , G01N33/6854
摘要： The present invention relates to a new cell based assay for combined determination of antibody or ligand binding and function in the same vial.
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公开(公告)号：US20230086210A1
公开(公告)日：2023-03-23
申请号：US17811376
申请日：2022-07-08
摘要： The invention relates to 4-1BBL trimer-containing antigen binding molecules comprising at least one antigen binding domain capable of specific binding to PD-L1 and their use in the treatment of cancer.
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公开(公告)号：US20210253724A1
公开(公告)日：2021-08-19
申请号：US17125533
申请日：2020-12-17
IPC分类号： C07K16/28 , C07K16/40 , C07K16/30 , A61K39/395 , A61K45/06
摘要： The invention relates to new bispecific antigen binding molecules, comprising (a) a first Fab fragment capable of specific binding to 4-1BB, (b) a second Fab fragment capable of specific binding to a target cell antigen, (c) a third Fab fragment capable of specific binding to 4-1BB, and (d) a Fc domain composed of a first and a second subunit capable of stable association, wherein the Fab fragments (a) and (b) are fused to each other, and to methods of producing these molecules and to methods of using the same.
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