公开(公告)号：US20200071411A1

公开(公告)日：2020-03-05

申请号：US16684258

申请日：2019-11-14

Applicant: Hoffmann-La Roche Inc. ,  Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Peter BRUENKER ,  Christina CLAUS ,  Claudia FERRARA KOLLER ,  Sandra GRAU-RICHARDS ,  Ralf HOSSE ,  Christian KLEIN ,  Viktor LEVITSKI ,  Pablo UMANA

IPC: C07K16/28 ,  C07K16/30 ,  C07K16/40

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) at least one moiety capable of specific binding to a target cell antigen, (b) at least one moiety capable of specific binding to a costimulatory TNF receptor family member, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20220025046A1

公开(公告)日：2022-01-27

申请号：US17218948

申请日：2021-03-31

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Juergen Peter BACHL ,  Alexander BUJOTZEK ,  Carina CANTRILL ,  Harald DUERR ,  Janine FAIGLE ,  Sabine IMHOF-JUNG ,  Christian KLEIN ,  Thomas KRAFT ,  Estelle MARRER-BERGER ,  Ekkehard MOESSNER ,  Laurene POUSSE ,  Petra RUEGER ,  Johannes SAM ,  Roland STAACK ,  Dietrich TUERCK ,  Pablo UMANA ,  Joerg ZIELONKA

IPC: C07K16/28 ,  C07K16/46 ,  A61P35/00 ,  C07K16/30 ,  A61K45/06

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20210009656A1

公开(公告)日：2021-01-14

申请号：US17030251

申请日：2020-09-23

Applicant: Hoffmann-La Roche Inc.

Inventor： Peter BRUENKER ,  Claudia Ferrara KOLLER ,  Sandra GRAU-RICHARDS ,  Christian KLEIN ,  Ekkehard MOESSNER ,  Pablo UMANA ,  Maria AMANN ,  Christina CLAUS ,  Wei XU

IPC: C07K14/705 ,  C07K16/28 ,  C07K14/715 ,  A61K47/68 ,  A61K39/395 ,  C07K16/14 ,  C07K16/24 ,  C07K16/30 ,  C07K16/40

Abstract: The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) one Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain, wherein the TNF family ligand trimer-containing antigen binding molecule is monovalent for the binding to the target cell antigen.

公开(公告)号：US20200277392A1

公开(公告)日：2020-09-03

申请号：US16584931

申请日：2019-09-26

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Sandra GRAU-RICHARDS ,  Christian KLEIN ,  Mudita PINCHA ,  Pablo UMAÑA

IPC: C07K16/28 ,  C07K16/18

Abstract: The invention relates to novel bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to tenascin C (TnC), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20230227584A1

公开(公告)日：2023-07-20

申请号：US17937440

申请日：2022-09-30

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Ali BRANSI ,  Peter BRUENKER ,  Janine FAIGLE ,  Sabine IMHOF-JUNG ,  Roland STAACK ,  Joerg ZIELONKA

IPC: C07K16/46 ,  C12N15/63

CPC classification number: C07K16/468 ,  C12N15/63 ,  C07K2317/31 ,  C07K2317/35 ,  C07K2317/55 ,  C07K2317/522

Abstract: The present invention relates to bispecific antibodies comprising a modified C-terminal crossfab fragment that have reduced or no reactivity against preexisting antidrug antibodies.

公开(公告)号：US20190211113A1

公开(公告)日：2019-07-11

申请号：US16218266

申请日：2018-12-12

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Peter BRUENKER ,  Christina CLAUS ,  Claudia FERRARA KOLLER ,  Sandra GRAU-RICHARDS ,  Ralf HOSSE ,  Christian KLEIN ,  Viktor LEVITSKI ,  Samuel MOSER ,  Pablo UMANA

IPC: C07K16/40 ,  C07K16/30 ,  C07K16/28

CPC classification number: C07K16/40 ,  C07K16/2875 ,  C07K16/2878 ,  C07K16/30 ,  C07K2317/21 ,  C07K2317/31 ,  C07K2317/33 ,  C07K2317/35 ,  C07K2317/41 ,  C07K2317/52 ,  C07K2317/522 ,  C07K2317/524 ,  C07K2317/526 ,  C07K2317/55 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/66 ,  C07K2317/71 ,  C07K2317/73 ,  C07K2317/74 ,  C07K2317/75 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94 ,  C07K2319/30 ,  C07K2319/32

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) four moities capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and a second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20200231691A1

公开(公告)日：2020-07-23

申请号：US16581756

申请日：2019-09-25

Applicant: Hoffmann-La Roche Inc.

Inventor： Sandra GRAU-RICHARDS ,  Christian KLEIN ,  Pablo UMAÑA ,  Maria AMANN ,  Laurene POUSSE

IPC: C07K16/28 ,  C07K16/30

Abstract: The invention relates to novel bispecific antigen binding molecules comprising (a) at least one moiety capable of specific binding to OX40, and (b) at least one moiety capable of specific binding to epithelial cell adhesion molecule (EpCAM), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20180356411A1

公开(公告)日：2018-12-13

申请号：US15745666

申请日：2016-06-21

Applicant: Hoffmann-La Roche Inc.

Inventor： Rosmarie ALBRECHT ,  Maria AMANN ,  Christina CLAUS ,  Sandra GRAU-RICHARDS ,  Joerg ZIELONKA

IPC: G01N33/542

CPC classification number: G01N33/542 ,  G01N33/5008 ,  G01N33/5023 ,  G01N33/6854

Abstract: The present invention relates to a new cell based assay for combined determination of antibody or ligand binding and function in the same vial.

公开(公告)号：US20240117049A1

公开(公告)日：2024-04-11

申请号：US18457729

申请日：2023-08-29

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Juergen Peter BACHL ,  Alexander BUJOTZEK ,  Carina CANTRILL ,  Harald DUERR ,  Janine FAIGLE ,  Sabine IMHOF-JUNG ,  Christian KLEIN ,  Thomas KRAFT ,  Estelle MARRER-BERGER ,  Ekkehard MOESSNER ,  Laurene POUSSE ,  Petra RUEGER ,  Johannes SAM ,  Roland STAACK ,  Dietrich TUERCK ,  Pablo UMANA ,  Joerg ZIELONKA

IPC: C07K16/28 ,  A61K45/06 ,  A61P35/00 ,  C07K16/30 ,  C07K16/46 ,  C12N15/63

CPC classification number: C07K16/2809 ,  A61K45/06 ,  A61P35/00 ,  C07K16/2878 ,  C07K16/30 ,  C07K16/468 ,  C12N15/63 ,  A61K2039/505

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.

公开(公告)号：US20220073646A1

公开(公告)日：2022-03-10

申请号：US17347257

申请日：2021-06-14

Applicant: Hoffmann-La Roche Inc.

Inventor： Maria AMANN ,  Peter BRUENKER ,  Christina CLAUS ,  Claudia FERRARA KOLLER ,  Sandra GRAU-RICHARDS ,  Ralf HOSSE ,  Christian KLEIN ,  Viktor LEVITSKI ,  Samuel MOSER ,  Pablo UMANA

IPC: C07K16/40 ,  C07K16/28 ,  C07K16/30

Abstract: The invention relates to novel bispecific antigen binding molecules, comprising (a) four moieties capable of specific binding to a costimulatory TNF receptor family member, (b) at least one moiety capable of specific binding to a target cell antigen, and (c) a Fc domain composed of a first and second subunit capable of stable association, and to methods of producing these molecules and to methods of using the same.