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公开(公告)号：US20240132590A1
公开(公告)日：2024-04-25
申请号：US18446032
申请日：2023-08-08
发明人： Anne FREIMOSER-GRUNDSCHOBER , Maria Valeria GONZALEZ NICOLINI , Ralf HOSSE , Alexander KNAUPP , Ekkehard MOESSNER , Wolfgang RICHTER , Halina TROCHANOWSKA , Pablo UMAÑA , Christian KLEIN , Inja WALDHAUER
CPC分类号： C07K16/2809 , A61P35/00 , C07K16/30 , A61K2039/505
摘要： The present invention generally relates to antibodies that bind to CD3 and CD19, e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20240042022A1
公开(公告)日：2024-02-08
申请号：US18244135
申请日：2023-09-08
发明人： Anne FREIMOSER-GRUNDSCHOBER , Thomas HOFER , Ralf HOSSE , Ekkehard MOESSNER , Valeria G. NICOLINI , Pablo UMAÑA , Inja WALDHAUER , Wolfgang RICHTER , Alexander KNAUPP , Halina TROCHANOWSKA
IPC分类号： A61K39/395 , A61P35/00 , C07K16/28 , C07K16/30
CPC分类号： A61K39/39558 , A61P35/00 , C07K16/2809 , C07K16/2863 , C07K16/3053 , A61K2039/505
摘要： The present invention generally relates to antibodies that bind to CD3, including multispecific antibodies e.g. for activating T cells. In addition, the present invention relates to polynucleotides encoding such antibodies, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the antibodies, and to methods of using them in the treatment of disease.
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公开(公告)号：US20230322950A1
公开(公告)日：2023-10-12
申请号：US18162508
申请日：2023-01-31
IPC分类号： C07K16/42 , C07K14/705 , C07K14/725 , A61K39/00
CPC分类号： C07K16/42 , C07K14/70521 , C07K14/70578 , C07K14/7051 , A61K39/4611 , A61K39/4633 , A61K39/4643 , C07K2319/03 , C07K2317/565 , C07K2319/02 , C07K2317/52 , C07K2317/24 , A61K38/00
摘要： The present invention generally relates to antigen binding receptors capable of specific binding to an Fc domain comprising the amino acid mutation P329G according to EU numbering. The present invention also relates to T cells, transduced with a antigen binding receptor which is recruited by specifically binding to/interacting with the mutated Fc domain of therapeutic antibodies. Furthermore, the invention relates to a kit comprising the transduced T cells of the invention and/or nucleic acid molecules, vectors encoding the antigen binding receptors of the present invention and tumor targeting antibodies comprising a mutated Fc domain.
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公开(公告)号：US20200316128A1
公开(公告)日：2020-10-08
申请号：US16906778
申请日：2020-06-19
发明人： Christian KLEIN , Ekkehard MOESSNER , Lydia Jasmin HANISCH , Wei XU , Camille Loise Sophie DELON , Diana DAROWSKI , Christian JOST , Vesna PULKO
摘要： The present invention generally relates to specificity assays using cell cultures, in particular to chimeric antigen receptor (CAR) expressing reporter T (CAR-T) cell assays to test novel antigen binding moieties in different formats. Furthermore, the present invention relates to the use of CAR-T cells, transfected/transduced with an engineered chimeric antigen receptor (CAR) comprising a target antigen binding moiety capable of specific binding to a recognition domain of an antigen binding molecule. The invention also relates to methods and kits for specificity testing of a candidate antigen binding moiety and/or nucleic acid molecules and vectors expressing engineered CARs.
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5.发明公开公开(公告)号：US20230212312A1
公开(公告)日：2023-07-06
申请号：US17837633
申请日：2022-06-10
CPC分类号： C07K16/32 , C07K16/18 , C07K16/2881 , A61K2039/507 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/73 , C07K2317/92 , C07K2317/94 , C07K2317/515 , C07K2317/622 , C07K2317/732 , C07K2317/734
摘要： The present invention relates to trispecific antibodies binding to HER2 and a blood-brain barrier receptor (BBB-R), methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
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公开(公告)号：US20220213224A1
公开(公告)日：2022-07-07
申请号：US17470778
申请日：2021-09-09
发明人： Christian KLEIN , Ekkehard MOESSNER , Ralf HOSSE , Peter BRUENKER , Pablo UMANA , Christiane NEUMANN
摘要： The present invention generally relates to novel bispecific antigen binding molecules for T cell activation and re-direction to specific target cells comprising a common light chain. In addition, the present invention relates to polynucleotides encoding such bispecific antigen binding molecules, and vectors and host cells comprising such polynucleotides. The invention further relates to methods for producing the bispecific antigen binding molecules of the invention, and to methods of using these bispecific antigen binding molecules in the treatment of disease.
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公开(公告)号：US20210009656A1
公开(公告)日：2021-01-14
申请号：US17030251
申请日：2020-09-23
发明人： Peter BRUENKER , Claudia Ferrara KOLLER , Sandra GRAU-RICHARDS , Christian KLEIN , Ekkehard MOESSNER , Pablo UMANA , Maria AMANN , Christina CLAUS , Wei XU
IPC分类号： C07K14/705 , C07K16/28 , C07K14/715 , A61K47/68 , A61K39/395 , C07K16/14 , C07K16/24 , C07K16/30 , C07K16/40
摘要： The invention relates to novel TNF family ligand trimer-containing antigen binding molecules comprising (a) one Fab domain capable of specific binding to a target cell antigen, (b) a Fc domain composed of a first and a second subunit capable of stable association, and (c) a first polypeptide comprising two ectodomains of a TNF ligand family member or fragments thereof that are connected to each other by a peptide linker and a second polypeptide comprising one ectodomain of said TNF ligand family member or a fragment thereof, wherein the first polypeptide is fused at its N-terminus to the C-terminus of one of the subunits of the Fc domain and wherein the second polypeptide is fused at its N-terminus to the C-terminus of the other subunit of the Fc domain, wherein the TNF family ligand trimer-containing antigen binding molecule is monovalent for the binding to the target cell antigen.
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公开(公告)号：US20200062826A1
公开(公告)日：2020-02-27
申请号：US16413469
申请日：2019-05-15
发明人： Ulrich BRINKMANN , Rebecca CROASDALE , Eike HOFFMANN , Christian KLEIN , Ekkehard MOESSNER , Juergen Michael SCHANZER , Claudio SUSTMANN , Pablo UMANA
摘要： The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing the antibodies, and uses thereof.
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公开(公告)号：US20180282409A1
公开(公告)日：2018-10-04
申请号：US15763868
申请日：2016-09-30
发明人： Claudia FERRARA KOLLER , Guy GEORGES , Alexander HAAS , Hubert KETTENBERGER , Ekkehard MOESSNER , Tilman SCHLOTHAUER , Michael MOLHOJ , Laurent LARIVIERE
IPC分类号： C07K16/28
摘要： Herein is reported an antibody that specifically binds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.
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公开(公告)号：US20180230215A1
公开(公告)日：2018-08-16
申请号：US15941519
申请日：2018-03-30
发明人： Thomas HOFER , Claudia FERRARA KOLLER , Ekkehard MOESSNER , Mi HE
CPC分类号： C07K16/2803 , A61P35/00 , C07K16/3061 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/92
摘要： The present invention relates to antibodies against human CD19 (anti-human CD19 antibodies), methods for their production, pharmaceutical compositions containing these antibodies, and methods of using the same.
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