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    Inhibitors of bruton's tyrosine kinase
    1.
    发明授权
    Inhibitors of bruton's tyrosine kinase 有权

    公开(公告)号：US09663494B2

    公开(公告)日：2017-05-30

    申请号：US14768705

    申请日：2014-03-03

    申请人： Hoffmann-La Roche Inc.

    发明人： Francisco Javier Lopez-Tapia

    IPC分类号： C07D401/14 ,  C07D413/14 ,  C07D471/04

    CPC分类号： C07D401/14 ,  C07D413/14 ,  C07D471/04

    摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    2.
    发明申请
    INHIBITORS OF BRUTON'S TYROSINE KINASE 有权
    BRUTON的酪氨酸激酶抑制剂

    公开(公告)号：US20150291525A1

    公开(公告)日：2015-10-15

    申请号：US14441711

    申请日：2013-11-13

    申请人： HOFFMANN-LA ROCHE INC.

    发明人： Romyr Dominique ,  Francisco Javier Lopez-Tapia ,  Eric Mertz ,  Sung-Sau So

    IPC分类号： C07D213/643 ,  C07D401/14 ,  C07D401/10

    CPC分类号： C07D213/643 ,  C07D211/82 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D495/04

    摘要： This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式（I）的化合物：其中所有变量如本文所述限定，其抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    3.
    发明申请
    INHIBITORS OF BRUTON'S TYROSINE KINASE 审中-公开
    BRUTON的酪氨酸激酶抑制剂

    公开(公告)号：US20150284394A1

    公开(公告)日：2015-10-08

    申请号：US14438008

    申请日：2013-10-23

    申请人： HOFFMANN-LA ROCHE INC.

    发明人： Niala Bhagirath ,  Romyr Dominique ,  Joshua Kennedy-Smith ,  Francisco Javier Lopez-Tapia ,  Eric Mertz ,  Qi Qiao ,  Sung-Sau So

    IPC分类号： C07D487/04 ,  C07D519/00

    CPC分类号： C07D487/04 ,  C07D519/00

    摘要： This application discloses compounds according to generic Formula I wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物，其中所有变量如本文所述限定Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Inhibitors of bruton's tyrosine kinase
    6.
    发明授权
    Inhibitors of bruton's tyrosine kinase 有权
    布鲁特酪氨酸激酶抑制剂

    公开(公告)号：US09556147B2

    公开(公告)日：2017-01-31

    申请号：US14768488

    申请日：2014-03-03

    申请人： Hoffmann-La Roche Inc.

    发明人： Christine E. Brotherton-Pleiss ,  Rama K. Kondru ,  Francisco Javier Lopez-Tapia ,  Yan Lou

    IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D237/30 ,  C07D401/14 ,  C07D237/32 ,  A61K31/502

    CPC分类号： C07D401/14 ,  A61K31/502 ,  C07D237/32

    摘要： This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物：（I）其中所有变量如本文所述限定BTK。 本文公开的化合物可用于调节BTK的活性并治疗与过量BTK活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Inhibitors of Bruton's tyrosine kinase
    9.
    发明授权
    Inhibitors of Bruton's tyrosine kinase 失效
    Bruton酪氨酸激酶抑制剂

    公开(公告)号：US08742098B2

    公开(公告)日：2014-06-03

    申请号：US13706399

    申请日：2012-12-06

    申请人： Hoffmann-La Roche Inc.

    发明人： Christine E. Brotherton-Pleiss ,  Francisco Javier Lopez-Tapia ,  Yan Lou

    IPC分类号： C07D413/14 ,  A61K31/5377

    CPC分类号： C07D413/14 ,  A61K31/5377 ,  C07D471/04 ,  C07D487/04

    摘要： This application discloses compounds according to generic Formula I: wherein the variables are defined as described herein, and which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物：其中变量如本文所述定义并且抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎性和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。