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    Inhibitors of bruton's tyrosine kinase
    3.
    发明授权
    Inhibitors of bruton's tyrosine kinase 有权
    布鲁特酪氨酸激酶抑制剂

    公开(公告)号：US09556147B2

    公开(公告)日：2017-01-31

    申请号：US14768488

    申请日：2014-03-03

    申请人： Hoffmann-La Roche Inc.

    发明人： Christine E. Brotherton-Pleiss ,  Rama K. Kondru ,  Francisco Javier Lopez-Tapia ,  Yan Lou

    IPC分类号： A61K31/50 ,  A61K31/501 ,  C07D237/30 ,  C07D401/14 ,  C07D237/32 ,  A61K31/502

    CPC分类号： C07D401/14 ,  A61K31/502 ,  C07D237/32

    摘要： This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物：（I）其中所有变量如本文所述限定BTK。 本文公开的化合物可用于调节BTK的活性并治疗与过量BTK活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Inhibitors of Bruton's tyrosine kinase
    6.
    发明授权
    Inhibitors of Bruton's tyrosine kinase 失效
    Bruton酪氨酸激酶抑制剂

    公开(公告)号：US08742098B2

    公开(公告)日：2014-06-03

    申请号：US13706399

    申请日：2012-12-06

    申请人： Hoffmann-La Roche Inc.

    发明人： Christine E. Brotherton-Pleiss ,  Francisco Javier Lopez-Tapia ,  Yan Lou

    IPC分类号： C07D413/14 ,  A61K31/5377

    CPC分类号： C07D413/14 ,  A61K31/5377 ,  C07D471/04 ,  C07D487/04

    摘要： This application discloses compounds according to generic Formula I: wherein the variables are defined as described herein, and which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation, such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物：其中变量如本文所述定义并且抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎性和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    7.
    发明申请
    INHIBITORS OF BRUTON'S TYROSINE KINASE 有权
    BRUTON的酪氨酸激酶抑制剂

    公开(公告)号：US20150210704A1

    公开(公告)日：2015-07-30

    申请号：US14427501

    申请日：2013-09-10

    申请人： Hoffmann-La Roche Inc.

    发明人： Christine E. Brotherton-Pleiss ,  Ramona Hilgenkamp ,  Rama K. Kondru ,  Francisco Javier Lopez-Tapia ,  Yan Lou

    IPC分类号： C07D487/04 ,  C07D405/14 ,  C07D401/14

    CPC分类号： C07D487/04 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14

    摘要： This application discloses compounds according to generic Formula I: wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物：其中所有变量如本文所述限定，其抑制Btk。 本文公开的化合物可用于调节Btk的活性并治疗与过量Btk活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。

    Substituted carbamate compounds
    9.
    发明授权
    Substituted carbamate compounds 有权
    取代氨基甲酸酯化合物

    公开(公告)号：US09388172B2

    公开(公告)日：2016-07-12

    申请号：US14707524

    申请日：2015-05-08

    申请人： Hoffmann-La Roche Inc.

    发明人： Christine E. Brotherton-Pleiss ,  Shawn David Erickson ,  Hongju Li ,  Sung-Sau So

    IPC分类号： C07D413/14 ,  C07D413/06 ,  C07D403/06 ,  C07D401/06 ,  C07D271/107

    CPC分类号： C07D413/06 ,  C07D271/107 ,  C07D401/06 ,  C07D403/06 ,  C07D413/14

    摘要： The invention is concerned with the compounds of formula (I): and pharmaceutically acceptable salts thereof. In addition, the present invention relates to methods of manufacturing and using the compounds of formula (I) as well as pharmaceutical compositions containing such compounds. The compounds of formula (I) are antagonists of the TRPA1 channel and may be useful in treating inflammatory diseases and disorders associated with that channel.

    摘要翻译： 本发明涉及式（I）化合物及其药学上可接受的盐。 此外，本发明涉及制备和使用式（I）化合物的方法以及含有这些化合物的药物组合物。 式（I）化合物是TRPA1通道的拮抗剂，可用于治疗与该通道相关的炎性疾病和病症。

    INHIBITORS OF BRUTON'S TYROSINE KINASE
    10.
    发明申请
    INHIBITORS OF BRUTON'S TYROSINE KINASE 有权
    BRUTON的酪氨酸激酶抑制剂

    公开(公告)号：US20160002206A1

    公开(公告)日：2016-01-07

    申请号：US14768488

    申请日：2014-03-03

    申请人： HOFFMANN-LA ROCHE INC.

    发明人： Christine E. Brotherton-Pleiss ,  Rama K. Kondru ,  Francisco Javier Lopez-Tapia ,  Yan Lou

    IPC分类号： C07D401/14

    CPC分类号： C07D401/14 ,  A61K31/502 ,  C07D237/32

    摘要： This application discloses compounds according to generic Formula I: (I) wherein all variables are defined as described herein, which inhibit BTK. The compounds disclosed herein are useful to modulate the activity of BTK and treat diseases associated with excessive BTK activity. The compounds are further useful to treat inflammatory and auto immune diseases associated with aberrant B-cell proliferation such as rheumatoid arthritis. Also disclosed are compositions containing compounds of Formula I and at least one carrier, diluent or excipient.

    摘要翻译： 本申请公开了根据通式I的化合物：（I）其中所有变量如本文所述限定BTK。 本文公开的化合物可用于调节BTK的活性并治疗与过量BTK活性相关的疾病。 该化合物还可用于治疗与异常B细胞增殖相关的炎症和自身免疫疾病，例如类风湿性关节炎。 还公开了含有式I化合物和至少一种载体，稀释剂或赋形剂的组合物。