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1.发明授权Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent 有权缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物公开(公告)号：US09574016B2
公开(公告)日：2017-02-21
申请号：US14539009
申请日：2014-11-12
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Lau , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/44 , A61K31/704 , A61K39/395 , A61K47/48 , B82Y5/00 , C07K16/28 , C07K16/32 , C12N15/11 , C12N15/113 , A61K49/00 , C07K16/30 , C12Q1/68 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
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2.发明申请COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 审中-公开复合抗生素和联合治疗或诊断代谢物的双特异性抗体公开(公告)号：US20160009823A1
公开(公告)日：2016-01-14
申请号：US14539009
申请日：2014-11-12
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
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