-
公开(公告)号：US12023378B2
公开(公告)日：2024-07-02
申请号：US16667464
申请日：2019-10-29
发明人： Joerg Benz , Ulrich Brinkmann , Stefan Dengl , Sebastian Dziadek , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann
IPC分类号： A61K39/385 , A61K39/00 , A61K47/68 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/28 , C07K16/40 , C07K16/44 , C07K16/46 , G01N33/68
CPC分类号： A61K39/385 , A61K47/6835 , A61K47/6879 , A61K47/6897 , B82Y5/00 , C07K16/00 , C07K16/16 , C07K16/2896 , C07K16/40 , C07K16/44 , C07K16/468 , G01N33/6857 , A61K2039/6056 , A61K2039/627 , C07K2317/24 , C07K2317/31 , C07K2317/40 , C07K2317/55 , C07K2317/565 , C07K2317/624 , C07K2317/94
摘要： Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
-
公开(公告)号：US11286300B2
公开(公告)日：2022-03-29
申请号：US15763868
申请日：2016-09-30
发明人： Claudia Ferrara Koller , Guy Georges , Alexander Haas , Hubert Kettenberger , Ekkehard Moessner , Tilman Schlothauer , Michael Molhoj , Laurent Lariviere
摘要： Herein is reported an antibody that specifically binds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.
-
3.发明授权Complex of bi-specific antibody and digoxigenin conjugated to a therapeutic or diagnostic agent 有权缀合于治疗或诊断剂的双特异性抗体和地高辛的复合物公开(公告)号：US09574016B2
公开(公告)日：2017-02-21
申请号：US14539009
申请日：2014-11-12
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Lau , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
IPC分类号： C07K16/44 , A61K31/704 , A61K39/395 , A61K47/48 , B82Y5/00 , C07K16/28 , C07K16/32 , C12N15/11 , C12N15/113 , A61K49/00 , C07K16/30 , C12Q1/68 , A61K39/00
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
-
4.发明申请COMPLEX OF BI-SPECIFIC ANTIBODY AND DIGOXIGENIN CONJUGATED TO A THERAPEUTIC OR DIAGNOSTIC AGENT 审中-公开复合抗生素和联合治疗或诊断代谢物的双特异性抗体公开(公告)号：US20160009823A1
公开(公告)日：2016-01-14
申请号：US14539009
申请日：2014-11-12
发明人： Ulrich Brinkmann , Rebecca Croasdale , Wilma Dormeyer , Guy Georges , Alexander Haas , Eike Hoffmann , Silke Metz , Olaf Mundigl , Werner Scheuer , Jan Olaf Stracke
CPC分类号： C07K16/44 , A61K31/704 , A61K39/39533 , A61K47/6879 , A61K47/6897 , A61K49/0045 , A61K49/0058 , A61K2039/505 , B82Y5/00 , C07K16/16 , C07K16/2803 , C07K16/2863 , C07K16/2896 , C07K16/32 , C07K2317/24 , C07K2317/31 , C07K2317/51 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2317/77 , C07K2317/92 , C07K2319/30 , C12N15/111 , C12N15/1138 , C12N2310/14 , C12N2310/3513 , C12N2320/32 , A61K2300/00
摘要： The present invention relates to complexes of a) bi-specific antibodies and antibody fragments against a target protein and b) a digoxigenin conjugated to a therapeutic or diagnostic agent, methods for their production, their use as a delivery platform for therapeutic or diagnostic agents, pharmaceutical compositions containing said antibodies, and uses thereof.
摘要翻译： 本发明涉及a）针对靶蛋白的双特异性抗体和抗体片段的复合物，和b）与治疗或诊断试剂缀合的地高辛，其生产方法，它们作为治疗或诊断试剂的递送平台的用途， 含有所述抗体的药物组合物及其用途。
-
公开(公告)号：US20220135672A1
公开(公告)日：2022-05-05
申请号：US17362126
申请日：2021-06-29
IPC分类号： C07K16/28 , C12N5/0781
摘要： Herein is reported an antibody binding to rabbit CD19 comprising (a) a HVR-H1 comprising the amino acid sequence of SEQ ID NO: 32 or 33 or 34, (b) a HVR-H2 comprising the amino acid sequence of SEQ ID NO: 35 or 36, (c) a HVR-H3 comprising the amino acid sequence of SEQ ID NO: 37, (d) a HVR-L1 comprising the amino acid sequence of SEQ ID NO: 38, (e) a HVR-L2 comprising the amino acid sequence of SEQ ID NO: 39, and (f) a HVR-L3 comprising the amino acid sequence of SEQ ID NO: 40, as well as methods of using the same, especially in the identification and selection of antibody producing rabbit B-cells.
-
公开(公告)号：US20130164219A1
公开(公告)日：2013-06-27
申请号：US13712088
申请日：2012-12-12
发明人： Ulrich Brinkmann , Alexander Haas , Daniela Maisel
IPC分类号： C07K14/435 , C07K1/107
CPC分类号： C07K14/47 , A61K47/6455 , C07K1/1075 , C07K1/1077 , C07K14/00 , C07K14/435
摘要： The present invention relates to the identification and functional characterization of human cell-penetrating peptides (CPPs) and their use; in particular as transfection vehicles.
-
公开(公告)号：US20220204616A1
公开(公告)日：2022-06-30
申请号：US17578655
申请日：2022-01-19
发明人： Claudia Ferrara Koller , Guy Georges , Alexander Haas , Hubert Kettenberger , Ekkehard Moessner , Tilman Schlothauer , Michael Molhoj , Laurent Lariviere
IPC分类号： C07K16/28
摘要： Herein is reported an antibody that specifically hinds to human CD 19, wherein the antibody comprises (a) HVR-H1 comprising the amino acid sequence of SEQ ID NO: 03, (b) HVR-H2 comprising the amino acid sequence of SEQ ID NO: 11, (c) HVR-H3 comprising the amino acid sequence of SEQ ID NO: 05, (d) HVR-L1 comprising the amino acid sequence of SEQ ID NO: 20 or 28, (e) HVR-L2 comprising the amino acid sequence of SEQ ID NO: 07, and (f) HVR-L3 comprising the amino acid sequence of SEQ ID NO: 08, as well as methods of using the same.
-
公开(公告)号：US10517945B2
公开(公告)日：2019-12-31
申请号：US14577084
申请日：2014-12-19
发明人： Joerg Benz , Ulrich Brinkmann , Stefan Dengl , Sebastian Dziadek , Guy Georges , Michael Grote , Alexander Haas , Eike Hoffmann
IPC分类号： C07K16/44 , C07K16/16 , A61K39/395 , A61K39/385 , C07K16/00 , C07K16/28 , C07K16/40 , B82Y5/00 , C07K16/46 , G01N33/68 , A61K47/68 , A61K39/00
摘要： Herein is reported a conjugate comprising an antigen and an antibody that specifically binds to the antigen wherein a covalent bond is formed between the antigen and an amino acid residue in the CDR2 of the antibody, an antibody comprising a cysteine residue at amino acid position 53 (according to Kabat) in the heavy chain CDR2 and uses thereof.
-
公开(公告)号：US09303075B2
公开(公告)日：2016-04-05
申请号：US13712088
申请日：2012-12-12
发明人： Ulrich Brinkmann , Alexander Haas , Daniela Maisel
IPC分类号： C07K14/435 , C07K1/107 , C07K14/47 , C07K14/00 , A61K47/48
CPC分类号： C07K14/47 , A61K47/6455 , C07K1/1075 , C07K1/1077 , C07K14/00 , C07K14/435
摘要： The present invention relates to the identification and functional characterization of human cell-penetrating peptides (CPPs) and their use; in particular as transfection vehicles.
摘要翻译： 本发明涉及人细胞穿透肽（CPP）的鉴定和功能表征及其用途; 特别是作为转染载体。
-
公开(公告)号：US09879095B2
公开(公告)日：2018-01-30
申请号：US13773167
申请日：2013-02-21
CPC分类号： C07K16/468 , C07K16/00 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/56 , C07K2317/624 , C07K2317/64 , C07K2319/00
摘要： The present invention relates to bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof.
-
-
-
-
-
-
-
-
-
搜索结果
11 条记录 (耗时 0.031 秒)
