公开(公告)号：US20180202938A1

公开(公告)日：2018-07-19

申请号：US15712378

申请日：2017-09-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Jose Cardoso-Menezes ,  Christian Hakemeyer ,  Gledson Emidio Jose ,  Ulrike Strauss ,  Silke Werz

IPC: G01N21/78 ,  G01N24/08 ,  G01N21/64 ,  G01N21/3577 ,  G01N21/359

Abstract: The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation.

公开(公告)号：US20140032127A1

公开(公告)日：2014-01-30

申请号：US13886869

申请日：2013-05-03

Applicant: Hoffmann-La Roche Inc.

Inventor： Jose Cardoso-Menezes ,  Christian Hakemeyer ,  Gledson Emidio Jose ,  Ulrike Strauss ,  Silke Werz

IPC: G01N21/78 ,  G01N24/08

CPC classification number: G01N21/78 ,  G01N21/3577 ,  G01N21/359 ,  G01N21/6486 ,  G01N24/087 ,  G01N2021/6423 ,  G01N2201/1293

Abstract: The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation.

Abstract translation: 本发明提供了选择用于培养表达目的蛋白质的哺乳动物细胞培养组分批次的方法，其中在培养中使用至少两种不同的组分。

公开(公告)号：US10816477B2

公开(公告)日：2020-10-27

申请号：US15712378

申请日：2017-09-22

Applicant: Hoffmann-La Roche Inc.

Inventor： Jose Cardoso-Menezes ,  Christian Hakemeyer ,  Gledson Emidio Jose ,  Ulrike Strauss ,  Silke Werz

IPC: G01N21/78 ,  G01N21/64 ,  G01N21/3577 ,  G01N24/08 ,  G01N21/359

Abstract: The invention provides a method for the selection of cultivation component batches to be used in the cultivation of a mammalian cell expressing a protein of interest wherein at least two different components are employed in the cultivation.

公开(公告)号：US20170177835A1

公开(公告)日：2017-06-22

申请号：US15192708

申请日：2016-06-24

Applicant: Hoffmann-La Roche Inc.

Inventor： Jose Cardoso-Menezes ,  Stefan Buziol ,  Pedro Felizardo

IPC: G06F19/00 ,  G01N35/00 ,  G01N21/27 ,  G01N21/359 ,  G01N21/65

CPC classification number: G16C20/70 ,  G01N21/278 ,  G01N21/359 ,  G01N21/65 ,  G01N35/00693 ,  G01N2035/0097 ,  G01N2201/129 ,  G16C20/20

Abstract: The present invention describes a method that is comprised of creating a set of synthetic samples that mimic a dynamic process or a specific process step or a variation thereof, to be used to develop multivariate monitoring calibrations and process supervisory control systems.