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公开(公告)号：US20180222993A1
公开(公告)日：2018-08-09
申请号：US15941524
申请日：2018-03-30
发明人： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
CPC分类号： C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20220025046A1
公开(公告)日：2022-01-27
申请号：US17218948
申请日：2021-03-31
发明人： Maria AMANN , Juergen Peter BACHL , Alexander BUJOTZEK , Carina CANTRILL , Harald DUERR , Janine FAIGLE , Sabine IMHOF-JUNG , Christian KLEIN , Thomas KRAFT , Estelle MARRER-BERGER , Ekkehard MOESSNER , Laurene POUSSE , Petra RUEGER , Johannes SAM , Roland STAACK , Dietrich TUERCK , Pablo UMANA , Joerg ZIELONKA
摘要： The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20170051071A1
公开(公告)日：2017-02-23
申请号：US15203057
申请日：2016-07-06
发明人： Petra RUEGER , Georg TIEFENTHALER , Ekkehard MOESSNER , Jens NIEWOEHNER , Adrian HUGENMATTER , Cuiying SHAO , Francesca ROS , Gang XU
IPC分类号： C07K16/28
CPC分类号： C07K16/2881 , A61K2039/505 , C07K16/18 , C07K2317/31 , C07K2317/35 , C07K2317/55 , C07K2317/56 , C07K2317/622 , C07K2319/33
摘要： Herein is reported a blood brain barrier shuttle module comprising a brain effector entity, a linker and one monovalent binding entity which binds to a blood brain barrier receptor, wherein the linker couples the effector entity to the monovalent binding entity which binds to the blood brain barrier receptor wherein the monovalent binding entity does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03).
摘要翻译： 本文报道了包含脑效应器实体，接头和结合血脑屏障受体的一个单价结合实体的血脑屏障穿梭模块，其中所述接头将效应实体与结合血脑屏障的单价结合实体相连 受体，其中所述单价结合实体不包含抗转铁蛋白受体抗体8D3（SEQ ID NO：01和SEQ ID NO：02）或变体抗转铁蛋白受体抗体8D3v（SEQ ID NO：01和 SEQ ID NO：03）。
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公开(公告)号：US20230331796A1
公开(公告)日：2023-10-19
申请号：US17850922
申请日：2022-06-27
CPC分类号： C07K14/472 , B01D15/3809 , C07K1/22 , C07K16/18 , C07K2317/92 , C07K2317/94 , C07K2319/00
摘要： Herein is reported a fusion polypeptide according to formula I (TAG-X1-C1qA-X2-C1qB-X3-C1qC-X4), comprising a fragment of SEQ ID NO: 01 (C1qA), a fragment of SEQ ID NO: 03 (C1qB), a fragment of SEQ ID NO: 05 (C1qC) and optionally a tag (TAG).
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公开(公告)号：US20220306761A1
公开(公告)日：2022-09-29
申请号：US17664609
申请日：2022-05-23
发明人： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20200216554A1
公开(公告)日：2020-07-09
申请号：US16822972
申请日：2020-03-18
发明人： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20240317879A1
公开(公告)日：2024-09-26
申请号：US18732998
申请日：2024-06-04
发明人： Harald DUERR , Sebastian FENN , Ulrich GOEPFERT , Sabine IMHOF-JUNG , Christian KLEIN , Laurent LARIVIERE , Michael MOLHOJ , Joerg Thomas REGULA , Petra RUEGER , Wolfgang SCHAEFER
CPC分类号： C07K16/2887 , A61P25/00 , C07K16/2881 , C07K2317/31 , C07K2317/515 , C07K2317/522 , C07K2317/55 , C07K2317/66 , C07K2317/92 , C07K2317/94
摘要： Herein are provided bispecific anti-human CD20/human transferrin receptor antibodies and methods of using the same.
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公开(公告)号：US20240117049A1
公开(公告)日：2024-04-11
申请号：US18457729
申请日：2023-08-29
发明人： Maria AMANN , Juergen Peter BACHL , Alexander BUJOTZEK , Carina CANTRILL , Harald DUERR , Janine FAIGLE , Sabine IMHOF-JUNG , Christian KLEIN , Thomas KRAFT , Estelle MARRER-BERGER , Ekkehard MOESSNER , Laurene POUSSE , Petra RUEGER , Johannes SAM , Roland STAACK , Dietrich TUERCK , Pablo UMANA , Joerg ZIELONKA
CPC分类号： C07K16/2809 , A61K45/06 , A61P35/00 , C07K16/2878 , C07K16/30 , C07K16/468 , C12N15/63 , A61K2039/505
摘要： The invention relates to novel bispecific antigen binding molecules, comprising at least two antigen binding domains capable of specific binding to OX40 and a particular antigen binding domain capable of specific binding to Fibroblast Activation Protein (FAP), and to methods of producing these molecules and to methods of using the same.
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公开(公告)号：US20200071413A1
公开(公告)日：2020-03-05
申请号：US16457267
申请日：2019-06-28
发明人： Petra RUEGER , Georg TIEFENTHALER , Ekkehard MOESSNER , Jens NIEWOEHNER , Adrian HUGENMATTER , Cuiying SHAO , Francesca ROS , Gang XU
摘要： Herein is reported a blood brain barrier shuttle module comprising a brain effector entity, a linker and one monovalent binding entity which binds to a blood brain barrier receptor, wherein the linker couples the effector entity to the monovalent binding entity which binds to the blood brain barrier receptor wherein the monovalent binding entity does not comprise the variable domains of the anti-transferrin receptor antibody 8D3 (SEQ ID NO: 01 and SEQ ID NO: 02) or of the variant anti-transferrin receptor antibody 8D3v (SEQ ID NO: 01 and SEQ ID NO: 03).
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