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公开(公告)号：US07846730B2
公开(公告)日：2010-12-07
申请号：US10728509
申请日：2003-12-05
申请人： Hong Zhang , Andrew T. Watt
发明人： Hong Zhang , Andrew T. Watt
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of BCL2-associated X protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding BCL2-associated X protein. Methods of using these compounds for modulation of BCL2-associated X protein expression and for treatment of diseases associated with expression of BCL2-associated X protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节BCL2相关的X蛋白的表达。 组合物包含靶向编码BCL2相关X蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节BCL2相关X蛋白表达和治疗与BCL2相关X蛋白表达有关的疾病的方法。
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公开(公告)号：US20110098340A1
公开(公告)日：2011-04-28
申请号：US12959234
申请日：2010-12-02
申请人： Hong Zhang , Andrew T. Watt
发明人： Hong Zhang , Andrew T. Watt
IPC分类号： C07H21/02 , A61K31/7105 , C12N5/07
CPC分类号： C12N15/113 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of BCL2-associated X protein. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding BCL2-associated X protein. Methods of using these compounds for modulation of BCL2-associated X protein expression and for treatment of diseases associated with expression of BCL2-associated X protein are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节BCL2相关的X蛋白的表达。 组合物包含靶向编码BCL2相关X蛋白的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节BCL2相关X蛋白表达和治疗与BCL2相关X蛋白表达有关的疾病的方法。
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公开(公告)号：US08664190B2
公开(公告)日：2014-03-04
申请号：US13302070
申请日：2011-11-22
申请人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina L. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina L. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
摘要翻译： 本文公开了用于降低具有升高的LDL-C的个体中的LDL-C的反义化合物和方法。 另外公开了用于治疗，预防或改善高胆固醇血症和/或动脉粥样硬化的反义化合物和方法。 进一步公开的是用于降低冠心病风险的反义化合物和方法。 这样的方法包括向需要治疗的个体施用靶向PCSK9核酸的反义化合物。 施用的反义化合物包括gapmer反义寡核苷酸。
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公开(公告)号：US07709453B2
公开(公告)日：2010-05-04
申请号：US10852630
申请日：2004-05-24
申请人： Donna T. Ward , Andrew T. Watt
发明人： Donna T. Ward , Andrew T. Watt
CPC分类号： C12N15/111 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2320/10 , C12N2320/50 , C12N2310/3525
摘要： Compounds, compositions and methods are provided for modulating the RNAi pathway. The compositions comprise oligonucleotides, targeted to nucleic acid molecules encoding EIF2C2. Methods of using these compounds for modulation of RNA interference as well as EIF2C2 expression and for diagnosis and treatment of disease associated with expression of EIF2C2 are provided. Also provided are compounds, compositions and methods for modulating the expression of DDX36. The compositions comprise oligonucleotides, targeted to nucleic acid encoding DDX36. Methods of using these compounds for modulation of DDX36 expression and for diagnosis and treatment of diseases and conditions associated with expression of DDX36 are provided.
摘要翻译： 提供化合物，组合物和方法用于调节RNAi途径。 组合物包含靶向编码EIF2C2的核酸分子的寡核苷酸。 提供了使用这些化合物调节RNA干扰以及EIF2C2表达以及用于诊断和治疗与EIF2C2表达相关的疾病的方法。 还提供了用于调节DDX36表达的化合物，组合物和方法。 组合物包含针对编码DDX36的核酸的寡核苷酸。 提供了使用这些化合物调制DDX36表达和用于诊断和治疗与DDX36表达相关的疾病和病症的方法。
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公开(公告)号：US06867039B2
公开(公告)日：2005-03-15
申请号：US09865993
申请日：2001-05-25
申请人： Brett P. Monia , Andrew T. Watt
发明人： Brett P. Monia , Andrew T. Watt
IPC分类号： A61K38/00 , A61K48/00 , C07H21/02 , C12N15/113 , C12Q1/68 , C12N5/00 , C07H21/04 , C12P19/34
CPC分类号： C12Y301/03016 , A61K38/00 , C07H21/04 , C12N15/1137 , C12N2310/11 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12N2310/3521 , C12Y301/03 , C12Y301/03048 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of dual specific phosphatase 5. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding dual specific phosphatase 5. Methods of using these compounds for modulation of dual specific phosphatase 5 expression and for treatment of diseases associated with expression of dual specific phosphatase 5 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节双特异性磷酸酶5的表达。该组合物包含靶向编码双特异性磷酸酶5的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节双特异性磷酸酶5的方法 提供了表达和用于治疗与双特异性磷酸酶5表达相关的疾病。
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公开(公告)号：US06566135B1
公开(公告)日：2003-05-20
申请号：US09679299
申请日：2000-10-04
申请人： Andrew T. Watt
发明人： Andrew T. Watt
IPC分类号： C12N1563
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , C12Y304/22059 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of caspase 6. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding caspase 6. Methods of using these compounds for modulation of caspase 6 expression and for treatment of diseases associated with expression of caspase 6 are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节半胱天冬酶6的表达。该组合物包含靶向编码半胱天冬酶6的核酸的反义化合物，特别是反义寡核苷酸。使用这些化合物调节半胱天冬酶6表达和治疗疾病的方法 提供与胱天蛋白酶6的表达相关的。
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公开(公告)号：US08093222B2
公开(公告)日：2012-01-10
申请号：US12478488
申请日：2009-06-04
申请人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina L. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
发明人： Susan M. Freier , Rosanne M. Crooke , Mark J. Graham , Kristina L. Lemonidis , Sanjay Bhanot , Diane Tribble , Andrew T. Watt
CPC分类号： C12N15/1137 , A61K45/06 , A61K48/00 , C12N2310/11 , C12N2310/321 , C12N2310/351 , C12N2320/30
摘要： Disclosed herein are antisense compounds and methods for decreasing LDL-C in an individual having elevated LDL-C. Additionally disclosed are antisense compounds and methods for treating, preventing, or ameliorating hypercholesterolemia and/or atherosclerosis. Further disclosed are antisense compounds and methods for decreasing coronary heart disease risk. Such methods include administering to an individual in need of treatment an antisense compound targeted to a PCSK9 nucleic acid. The antisense compounds administered include gapmer antisense oligonucleotides.
摘要翻译： 本文公开了用于降低具有升高的LDL-C的个体中的LDL-C的反义化合物和方法。 另外公开了用于治疗，预防或改善高胆固醇血症和/或动脉粥样硬化的反义化合物和方法。 进一步公开的是用于降低冠心病风险的反义化合物和方法。 这样的方法包括向需要治疗的个体施用靶向PCSK9核酸的反义化合物。 施用的反义化合物包括gapmer反义寡核苷酸。
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公开(公告)号：US06965025B2
公开(公告)日：2005-11-15
申请号：US10006191
申请日：2001-12-10
申请人： William Gaarde , Andrew T. Watt
发明人： William Gaarde , Andrew T. Watt
IPC分类号： A61K38/00 , C12N15/113 , C07H21/04 , A61K48/00 , C12N15/00
CPC分类号： C12N15/1136 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of connective tissue growth factor. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding connective tissue growth factor. Methods of using these compounds for modulation of connective tissue growth factor expression and for treatment of diseases associated with expression of connective tissue growth factor are provided.
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公开(公告)号：US06551826B1
公开(公告)日：2003-04-22
申请号：US09705267
申请日：2000-11-01
申请人： Andrew T. Watt
发明人： Andrew T. Watt
IPC分类号： C07H2104
CPC分类号： C12N15/1138 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of RAIDD. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding RAIDD. Methods of using these compounds for modulation of RAIDD expression and for treatment of diseases associated with expression of RAIDD are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节RAIDD的表达。 组合物包含靶向编码RAIDD的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节RAIDD表达和治疗与RAIDD表达相关疾病的方法。
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公开(公告)号：US06444466B1
公开(公告)日：2002-09-03
申请号：US09853768
申请日：2001-05-10
申请人： Donna T. Ward , Andrew T. Watt
发明人： Donna T. Ward , Andrew T. Watt
IPC分类号： C12Q168
CPC分类号： C12N15/1137 , A61K38/00 , C12N2310/315 , C12N2310/321 , C12N2310/3341 , C12N2310/341 , C12N2310/346 , Y02P20/582 , C12N2310/3525
摘要： Antisense compounds, compositions and methods are provided for modulating the expression of helicase-moi. The compositions comprise antisense compounds, particularly antisense oligonucleotides, targeted to nucleic acids encoding helicase-moi. Methods of using these compounds for modulation of helicase-moi expression and for treatment of diseases associated with expression of helicase-moi are provided.
摘要翻译： 提供反义化合物，组合物和方法用于调节解旋酶的表达。 组合物包含靶向编码解旋酶的核酸的反义化合物，特别是反义寡核苷酸。 提供了使用这些化合物调节解旋酶 - moi表达和治疗与解旋酶moi表达有关的疾病的方法。
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