公开(公告)号：US20120289571A1

公开(公告)日：2012-11-15

申请号：US13520120

申请日：2010-12-30

申请人： Hong Zhao ,  Dechun Wu ,  Snehlata Tripathi ,  Jing Xia

发明人： Hong Zhao ,  Dechun Wu ,  Snehlata Tripathi ,  Jing Xia

IPC分类号： C07D403/14 ,  A61K31/404 ,  A61P35/00 ,  C07D403/06

CPC分类号： C07D403/06 ,  C07D403/14

摘要： The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.

摘要翻译： 本发明涉及包含含胺化合物和生物活性剂的可释放的尿素连接体系。 特别地，本发明涉及基于分子内环化辅助的可释放脲键与含芳香胺的化合物的可逆释放接头。 本发明还涉及基于二氢吲哚酮的酪氨酸激酶抑制剂的聚合物缀合物。

公开(公告)号：US20200231620A1

公开(公告)日：2020-07-23

申请号：US16648146

申请日：2018-09-17

申请人： Keith Andrew BOWMAN ,  Chandra VARGEESE ,  David Charles Donnell BUTLER ,  Pachamuthu KANDASAMY ,  Mohammed Rowshon ALAM ,  Mamoru SHIMIZU ,  Stephany Michelle STANDLEY ,  Vincent ADUDA ,  Gopal Reddy BOMMINENI ,  Snehlata TRIPATHI ,  Ilia KORBOUKH ,  WAVE LIFE SCIENCES LTD.

发明人： Keith Andrew Bowman ,  Chandra Vargeese ,  David Charles Donnell Butler ,  Pachamuthu Kandasamy ,  Mohammed Rowshon Alam ,  Mamoru Shimizu ,  Stephany Michelle Standley ,  Vincent Aduda ,  Gopal Reddy Bommineni ,  Snehlata Tripathi ,  Ilia Korboukh

IPC分类号： C07H21/02 ,  C07H21/04

摘要： Among other things, the present disclosure provides technologies for oligonucleotide preparation, particularly chirally controlled oligonucleotide preparation, which technologies provide greatly improved crude purity and yield, and significantly reduce manufacturing costs.

公开(公告)号：US06541626B2

公开(公告)日：2003-04-01

申请号：US09836127

申请日：2001-04-17

申请人： Yogesh S. Sanghvi ,  Krishna Misra ,  Snehlata Tripathi

发明人： Yogesh S. Sanghvi ,  Krishna Misra ,  Snehlata Tripathi

IPC分类号： C07H1916

CPC分类号： C07H19/16

摘要： Methods for selectively protecting the exocyclic amino function of a purine nucleoside are provided using activating agents to effect acylation at the exocyclic amino site. Methods are also provided for recycling polymer bound coupling supports from the reaction mixtures produced upon N-acylation.