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    POLYMERIC CONJUGATES OF AROMATIC AMINE CONTAINING COMPOUNDS INCLUDING RELEASABLE UREA LINKER
    1.
    发明申请
    POLYMERIC CONJUGATES OF AROMATIC AMINE CONTAINING COMPOUNDS INCLUDING RELEASABLE UREA LINKER 审中-公开
    包含可释放尿素连接剂的芳香胺包含化合物的聚合物

    公开(公告)号：US20120289571A1

    公开(公告)日：2012-11-15

    申请号：US13520120

    申请日：2010-12-30

    申请人： Hong Zhao ,  Dechun Wu ,  Snehlata Tripathi ,  Jing Xia

    发明人： Hong Zhao ,  Dechun Wu ,  Snehlata Tripathi ,  Jing Xia

    IPC分类号： C07D403/14 ,  A61K31/404 ,  A61P35/00 ,  C07D403/06

    CPC分类号： C07D403/06 ,  C07D403/14

    摘要： The present invention relates to releasable urea linker systems involving amine-containing chemical compounds and biologically active agents. In particular, the present invention relates to reversibly releasable linkers based on intramolecular cyclization-assisted releasable urea linkages to aromatic amine-containing compounds. The present invention also relates to polymeric conjugates of indolinone-based tyrosine kinase inhibitors.

    摘要翻译： 本发明涉及包含含胺化合物和生物活性剂的可释放的尿素连接体系。 特别地，本发明涉及基于分子内环化辅助的可释放脲键与含芳香胺的化合物的可逆释放接头。 本发明还涉及基于二氢吲哚酮的酪氨酸激酶抑制剂的聚合物缀合物。

    RELEASABLE CONJUGATES FOR NUCLEIC ACIDS DELIVERY SYSTEMS
    2.
    发明申请
    RELEASABLE CONJUGATES FOR NUCLEIC ACIDS DELIVERY SYSTEMS 审中-公开
    用于核酸输送系统的可释放接头

    公开(公告)号：US20110230420A1

    公开(公告)日：2011-09-22

    申请号：US13129705

    申请日：2009-11-17

    申请人： Hong Zhao ,  Jing Xia ,  Prasanna Reddy

    发明人： Hong Zhao ,  Jing Xia ,  Prasanna Reddy

    IPC分类号： A61K38/14 ,  C12N5/00 ,  C07K9/00 ,  A61P35/00

    CPC分类号： A61K31/00

    摘要： The present invention is directed to nucleic acids delivery systems and methods of modulating an expression of a target gene using the same. In particular, the invention relates to nucleic acids conjugates containing an endosomal release-promoting moiety. The nucleic acids conjugates further contain a nuclear localization signal moiety, and/or a cell targeting moiety.

    摘要翻译： 本发明涉及使用其调节靶基因表达的核酸递送系统和方法。 特别地，本发明涉及含有内体释放促进部分的核酸缀合物。 核酸缀合物还含有核定位信号部分和/或细胞靶向部分。

    Methods of preparing polymers having terminal amine groups
    3.
    发明授权
    Methods of preparing polymers having terminal amine groups 失效
    制备具有末端胺基团的聚合物的方法

    公开(公告)号：US07868131B2

    公开(公告)日：2011-01-11

    申请号：US11508507

    申请日：2006-08-23

    申请人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    发明人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    IPC分类号： C08G79/02 ,  C08G79/08 ,  C08G73/00

    CPC分类号： C08G65/33303 ,  A61K47/60

    摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

    摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括在溶剂中使含有末端叠氮化物的聚乙二醇与膦类还原剂如三苯基膦或碱金属硼氢化物还原剂如硼氢化钠的聚环氧烷反应进行反应。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

    Method of preparing polymers having terminal amine groups
    4.
    发明授权
    Method of preparing polymers having terminal amine groups 失效
    制备具有末端胺基团的聚合物的方法

    公开(公告)号：US07301003B2

    公开(公告)日：2007-11-27

    申请号：US11212901

    申请日：2005-08-26

    申请人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    发明人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    IPC分类号： C08G79/02 ,  C08G79/08 ,  C08G73/00

    CPC分类号： C08G65/33303 ,  A61K47/60

    摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

    摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括在溶剂中使含有末端叠氮化物的聚乙二醇与膦类还原剂如三苯基膦或碱金属硼氢化物还原剂如硼氢化钠的聚环氧烷反应进行反应。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

    Methods of preparing polymers having terminal amine groups
    5.
    发明申请
    Methods of preparing polymers having terminal amine groups 审中-公开

    公开(公告)号：US20070049726A1

    公开(公告)日：2007-03-01

    申请号：US11291546

    申请日：2005-12-01

    申请人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    发明人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    IPC分类号： C08G79/02

    CPC分类号： C08G65/33303 ,  A61K47/60

    摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

    Methods of preparing polymers having terminal amine groups
    6.
    发明申请
    Methods of preparing polymers having terminal amine groups 失效
    制备具有末端胺基团的聚合物的方法

    公开(公告)号：US20070049725A1

    公开(公告)日：2007-03-01

    申请号：US11212901

    申请日：2005-08-26

    申请人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    发明人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    IPC分类号： C08G79/02

    CPC分类号： C08G65/33303 ,  A61K47/60

    摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

    摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括在溶剂中使含有末端叠氮化物的聚乙二醇与膦类还原剂如三苯基膦或碱金属硼氢化物还原剂如硼氢化钠的聚环氧烷反应进行反应。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

    POLYMERIC CONJUGATES OF ADENINE NUCLEOSIDE ANALOGS
    7.
    发明申请
    POLYMERIC CONJUGATES OF ADENINE NUCLEOSIDE ANALOGS 审中-公开
    聚腺苷酸类似物的聚合物

    公开(公告)号：US20130018010A1

    公开(公告)日：2013-01-17

    申请号：US13637297

    申请日：2011-04-15

    申请人： Hong Zhao ,  Jing Xia

    发明人： Hong Zhao ,  Jing Xia

    IPC分类号： A61K31/7064 ,  A61P31/12 ,  C07H19/16 ,  A61P35/00 ,  A61K31/7076 ,  C07H19/23

    CPC分类号： A61K47/60

    摘要： The present invention relates to polymeric conjugates of adenine nucleoside analogs. In particular, the invention relates to multi-arm polyethylene glycol conjugates of adenine nucleoside analogs and use thereof. The present invention, more specifically, provides polymeric conjugates of toyocamycin and its derivatives. Furthermore, the present invention provides a method for preparing the polymeric conjugates of adenine nucleoside analogs and a method of using the same for treating a cancer, inhibiting the growth or proliferation of cancer cells, treating a viral infection, treating a disease or condition associated with abnormal expression of VEGF. Most polymeric conjugates of toyocamycin was stable in PBS but released toyocamycin in vivo to provided inhibition of cancer cell growth.

    摘要翻译： 本发明涉及腺嘌呤核苷类似物的聚合物缀合物。 特别地，本发明涉及腺嘌呤核苷类似物的多臂聚乙二醇缀合物及其用途。 更具体地，本发明提供了toyocamycin及其衍生物的聚合物缀合物。 此外，本发明提供了制备腺嘌呤核苷类似物的聚合物缀合物的方法及其用于治疗癌症的方法，抑制癌细胞的生长或增殖，治疗病毒感染，治疗与 VEGF异常表达。 托卡霉素的大多数聚合物缀合物在PBS中是稳定的，但在体内释放了toyocamycin以提供对癌细胞生长的抑制。

    Methods of preparing polymers having terminal amine groups
    9.
    发明申请
    Methods of preparing polymers having terminal amine groups 失效
    制备具有末端胺基团的聚合物的方法

    公开(公告)号：US20080249260A1

    公开(公告)日：2008-10-09

    申请号：US11508507

    申请日：2006-08-23

    申请人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    发明人： Hong Zhao ,  Belen Rubio ,  Jing Xia

    IPC分类号： C08F8/04

    CPC分类号： C08G65/33303 ,  A61K47/60

    摘要： The present invention is directed to methods of preparing linear polymers such as polyalkylene oxides containing a terminal amine in high purity. One preferred method includes reacting a polyalkylene oxide such as polyethylene glycol containing a terminal azide with a phosphine-based reducing agent such as triphenylphosphine or an alkali metal borohydride reducing agent such as sodium borohydride in a solvent to reflux. The resultant polymer-amines are of sufficient purity so that expensive and time consuming purification steps required for pharmaceutical grade polymers are avoided.

    摘要翻译： 本发明涉及制备高纯度的含有末端胺的聚环氧烷的线性聚合物的方法。 一种优选的方法包括在溶剂中使含有末端叠氮化物的聚乙二醇与膦类还原剂如三苯基膦或碱金属硼氢化物还原剂如硼氢化钠的聚环氧烷反应进行反应。 得到的聚合物胺具有足够的纯度，因此避免了医药级聚合物所需的昂贵且耗时的纯化步骤。

    Method and bus system for equalizing data information traffic and decoder
    10.
    发明授权
    Method and bus system for equalizing data information traffic and decoder 有权
    用于均衡数据信息流量和解码器的方法和总线系统

    公开(公告)号：US08650346B2

    公开(公告)日：2014-02-11

    申请号：US13250458

    申请日：2011-09-30

    申请人： Jing Xia

    发明人： Jing Xia

    IPC分类号： G06F13/42 ,  G06F3/00 ,  G06F5/00

    CPC分类号： H04L12/403

    摘要： In the field of integrated circuit (IC) design, a method and a bus system for equalizing data information traffic and a decoder are provided. The method includes: receiving data information sent by a device, and allocating at least two transmission interfaces for the data information according to a decoding result of decoding a designated bit in the data information, where the data information carries a device ID, and the designated bit position occupied at least one bit in the device ID; judging whether the data information traffic of the at least two transmission interfaces is balanced; and when the data information traffic of the at least two transmission interfaces is not balanced, switching the designated bit position, and decoding the designated bit after switching, so as to balance the traffic of the at least two transmission interfaces. The bus system includes an interface allocation module, a traffic judging module and a bit position switching module. The decoder includes a decoding module and a designated bit position switching module.

    摘要翻译： 在集成电路（IC）设计领域，提供了一种用于均衡数据信息业务和解码器的方法和总线系统。 该方法包括：接收设备发送的数据信息，并根据解码数据信息中指定位的解码结果为数据信息分配至少两个传输接口，其中数据信息携带设备ID，指定 位位置占用设备ID中的至少一位; 判断所述至少两个传输接口的数据信息业务是否平衡; 并且当所述至少两个传输接口的数据信息业务不平衡时，切换指定的比特位置，并且在切换之后解码指定的比特，以平衡所述至少两个传输接口的业务。 总线系统包括接口分配模块，业务判断模块和位位置交换模块。 解码器包括解码模块和指定的比特位置切换模块。