公开(公告)号：US20100064780A1

公开(公告)日：2010-03-18

申请号：US11989344

申请日：2006-07-27

申请人： Howard A Stone

发明人： Howard A Stone

IPC分类号： G01L7/18 ,  G01N7/00

CPC分类号： G01L7/187 ,  B01L3/502715 ,  B01L3/50273 ,  B01L3/502746 ,  B01L2200/0647 ,  B01L2200/146 ,  B01L2300/0627 ,  G01N11/08

摘要： Methods and apparatus for measuring changes in pressure in a fluidic system are described. In one aspect, an apparatus for measuring pressure as described herein includes a test channel (e.g., a first fluidic channel (120)) and a control channel (e.g., a second fluidic channel (125)) that join a measuring region (130) downstream of the test and control channels. In some embodiments, fluid flowing in the test and control channels can be laminar and form a stable fluid interface in the measuring region. A property of the fluid interface, such as the position of the fluid interface, e.g., relative to a width of the measuring region, may be measured, in some cases visually. In some embodiments, introduction of a component (e.g., a cell) into the test channel can cause a change in pressure drop in the test channel. This change in pressure drop can cause a deflection of the fluid interface. The amplitude of deflection of the fluid interface can be correlated with the change in pressure caused by the introduction of the component in the test channel. In some cases, changes in pressure can be associated with a characteristic (e.g., a mechanical property) of the component. Advantageously, changes in pressure can be measured dynamically and in real time.

摘要翻译： 描述了用于测量流体系统中的压力变化的方法和装置。 一方面，如本文所述的用于测量压力的装置包括连接测量区域（130）的测试通道（例如，第一流体通道（120））和控制通道（例如，第二流体通道（125））， 测试和控制渠道的下游。 在一些实施例中，在测试和控制通道中流动的流体可以是层流的并且在测量区域中形成稳定的流体界面。 流体界面的特性，例如流体界面的位置，例如相对于测量区域的宽度，可以在某些情况下在视觉上被测量。 在一些实施例中，将组件（例如，单元）引入测试通道可导致测试通道中的压降的变化。 压差的这种变化可能导致流体界面的偏转。 流体界面的偏转幅度可以与由测试通道中的部件引入引起的压力变化相关。 在一些情况下，压力的变化可以与部件的特性（例如，机械特性）相关联。 有利地，可以动态地和实时地测量压力的变化。