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公开(公告)号:US20070031491A1
公开(公告)日:2007-02-08
申请号:US11431611
申请日:2006-05-11
IPC分类号: A61K9/22
CPC分类号: A61K9/006 , A61K9/0031 , A61K9/0034
摘要: A bioadhesive controlled, extended release progressive hydration composition wherein the active ingredient may be protected from water or the surrounding environment, thereby protecting it from metabolism or from other degradation caused by moisture, enzymes, or pH effects, and making it bioavailable only at a controlled rate. The active ingredient may be protected from moisture during the manufacturing process, as necessary or desired, and more importantly may be protected from moisture and the immediate septic environment until well after the patient has applied the composition, and then only at a slow and controlled rate. It is by this process of progressive hydration that the active ingredient remains protected for many hours after administration. It is also by the process of progressive hydration that controlled and sustained release is achieved because only that part of the active ingredient that is the hydrated (aqueous) fraction of the composition is available for absorption (bioavailable).
摘要翻译: 生物粘附控制的延长释放的进行性水合组合物,其中活性成分可以被保护免受水或周围环境的影响,从而保护其免受代谢或由水分,酶或pH影响引起的其它降解,并且仅在受控的 率。 活性成分可根据需要或需要在制造过程中得到保护,并且更重要的是可以保护免受潮湿和直接的败血症环境,直到患者施用组合物,然后仅以缓慢和受控的速率 。 正是通过这种进行性水合过程,活性成分在给药后保持多个小时。 还通过进行水合的过程,控制和持续释放是实现的,因为只有作为组合物的水合(水)部分的活性成分的那部分可用于吸收(生物可利用的)。
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公开(公告)号:US20100152730A1
公开(公告)日:2010-06-17
申请号:US12643788
申请日:2009-12-21
申请人: Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
发明人: Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
CPC分类号: A61L26/0023 , A61F13/00017 , A61F2013/00357 , A61K9/006 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/64 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/608 , Y10T156/10
摘要: A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments include a method for increasing the adhesion between tissue and the film or covering.
摘要翻译: 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置,包括扁桃体切除术,腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物,以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施例包括用于增加组织和膜或覆盖物之间的粘附的方法。
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公开(公告)号:USD426289S
公开(公告)日:2000-06-06
申请号:US97227
申请日:1998-12-02
申请人: Howard Levine
设计人: Howard Levine
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公开(公告)号:US20110112512A1
公开(公告)日:2011-05-12
申请号:US12639919
申请日:2009-12-16
申请人: Ketan P. Muni , Hung V. Ha , Randy S. Chan , Daniel T. Harfe , Howard Levine
发明人: Ketan P. Muni , Hung V. Ha , Randy S. Chan , Daniel T. Harfe , Howard Levine
IPC分类号: A61M29/02
CPC分类号: A61B17/24 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B17/3478 , A61B2090/062 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/0102 , A61M25/04 , A61M25/0662 , A61M25/10 , A61M27/00 , A61M29/02 , A61M31/00 , A61M2025/0018 , A61M2025/0681 , A61M2025/105 , A61M2025/1054 , A61M2210/0681
摘要: Devices and methods are described for improving drainage and/or aeration of maxillary sinuses and for treating maxillary sinus disease. Spacer devices are implanted through natural or man-made openings in the maxillary sinus. In some embodiments, the spacer device is loaded with a therapeutic substance which then exits the device over a desired time period to treat maxillary sinus disease.
摘要翻译: 描述了用于改善上颌窦引流和/或通气并用于治疗上颌窦疾病的装置和方法。 通过上颌窦中的天然或人造开口植入间隔器。 在一些实施方案中,间隔装置装有治疗物质,然后治疗物质在所需时间段内离开装置以治疗上颌窦疾病。
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公开(公告)号:US09351750B2
公开(公告)日:2016-05-31
申请号:US12639919
申请日:2009-12-16
申请人: Ketan P. Muni , Hung V. Ha , Randy S. Chan , Daniel T. Harfe , Howard Levine
发明人: Ketan P. Muni , Hung V. Ha , Randy S. Chan , Daniel T. Harfe , Howard Levine
IPC分类号: A61B17/24 , A61F11/00 , A61M25/10 , A61M29/02 , A61M31/00 , A61B17/34 , A61B19/00 , A61M25/00 , A61M25/01 , A61M25/04 , A61M25/06 , A61M27/00
CPC分类号: A61B17/24 , A61B17/3415 , A61B17/3417 , A61B17/3421 , A61B17/3478 , A61B2090/062 , A61F11/004 , A61M25/0075 , A61M25/0084 , A61M25/0102 , A61M25/04 , A61M25/0662 , A61M25/10 , A61M27/00 , A61M29/02 , A61M31/00 , A61M2025/0018 , A61M2025/0681 , A61M2025/105 , A61M2025/1054 , A61M2210/0681
摘要: Devices and methods are described for improving drainage and/or aeration of maxillary sinuses and for treating maxillary sinus disease. Spacer devices are implanted through natural or man-made openings in the maxillary sinus. In some embodiments, the spacer device is loaded with a therapeutic substance which then exits the device over a desired time period to treat maxillary sinus disease.
摘要翻译: 描述了用于改善上颌窦引流和/或通气并用于治疗上颌窦疾病的装置和方法。 通过上颌窦中的天然或人造开口植入间隔器。 在一些实施方案中,间隔装置装有治疗物质,然后治疗物质在所需时间段内离开装置以治疗上颌窦疾病。
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公开(公告)号:US20090181074A1
公开(公告)日:2009-07-16
申请号:US12341315
申请日:2008-12-22
申请人: Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
发明人: Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
CPC分类号: A61L26/0023 , A61F13/00017 , A61F2013/00357 , A61K9/006 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/64 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/608 , Y10T156/10
摘要: A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments may include one or more therapeutic substances for locally reducing pain, facilitating healing and/or otherwise treating mucosal tissue at or near a tonsil bed.
摘要翻译: 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置,包括扁桃体切除术,腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物,以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施方案可以包括一种或多种用于局部减轻疼痛,促进愈合和/或以其他方式治疗扁桃体床处或附近的治疗物质。
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公开(公告)号:US11930922B1
公开(公告)日:2024-03-19
申请号:US18504691
申请日:2023-11-08
申请人: Howard Levine
发明人: Howard Levine
CPC分类号: A47B47/045 , A47B45/00 , A47B57/545 , A47B57/06 , A47B57/10
摘要: An expandable stand-alone shelving assembly includes a post assembly and an expandable shelf. The post assembly includes an elongated post and a sleeve coupled to the elongated post. The expandable shelf includes an aperture, a first half, a second half, and an internal mechanism. The aperture accepts the sleeve of the post assembly. The first half of the expandable shelf includes a surface, a top end, and a bottom end. The second half of the expandable shelf includes an angled portion extending downwards from a surface of the second half. The internal mechanism includes a reinforcement bar connecting the top end and the bottom end of the first half, and a stop. The second half is slidably received within the first half. The stop of the internal mechanism engages with the angled portion of the second half to prevent the second half and first half from sliding apart.
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公开(公告)号:US08795713B2
公开(公告)日:2014-08-05
申请号:US12341315
申请日:2008-12-22
申请人: Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
发明人: Joshua Makower , John Y. Chang , Ketan P. Muni , Wenda Carlyle , Howard Levine , William M. Facteau
CPC分类号: A61L26/0023 , A61F13/00017 , A61F2013/00357 , A61K9/006 , A61L15/42 , A61L15/44 , A61L15/58 , A61L15/64 , A61L26/0061 , A61L26/0066 , A61L26/009 , A61L2300/402 , A61L2300/406 , A61L2300/41 , A61L2300/608 , Y10T156/10
摘要: A method and apparatus for reducing or eliminating pain after surgical procedures related to mucosal tissue, including tonsillectomy, adenoidectomy, or other pharyngeal operations. Certain embodiments provide a biodegradable film or covering that serves as a mechanical barrier to reduce pain caused, for example, by friction between solid food and healing tissue in the first few days after surgery. Some embodiments may include one or more therapeutic substances for locally reducing pain, facilitating healing and/or otherwise treating mucosal tissue at or near a tonsil bed.
摘要翻译: 用于减少或消除与粘膜组织相关的外科手术后疼痛的方法和装置,包括扁桃体切除术,腺样体切除术或其他咽部手术。 某些实施方案提供用作机械屏障的可生物降解的膜或覆盖物,以减少例如在手术后的头几天固体食物与愈合组织之间的摩擦所引起的疼痛。 一些实施方案可以包括一种或多种用于局部减轻疼痛,促进愈合和/或以其他方式治疗扁桃体床处或附近的治疗物质。
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