公开(公告)号：US20250082668A1

公开(公告)日：2025-03-13

申请号：US18959847

申请日：2024-11-26

Applicant: Howard University

Inventor： James W. MITCHELL ,  Dazhi YANG

IPC: A61K31/785 ,  A61K9/14 ,  A61K31/738 ,  A61P7/08 ,  B01J20/26 ,  B01J20/28 ,  B01J20/30 ,  C08B15/06 ,  C08F251/02 ,  C08G73/02 ,  C08G81/00 ,  C08G83/00 ,  C08G101/00 ,  C08J9/16 ,  C08L1/08 ,  C08L3/20 ,  C08L5/02 ,  C08L5/08

Abstract: Covalently cross-linked copolymers are described herein. More specifically, polysaccharide-polyamine copolymeric matrices or structures and cationic copolymeric matrices are described herein. The polysaccharide-polyamine copolymers, when protonated, can form cationic copolymeric matrices having exceptionally high densities of cationic sites. In one form, the covalently cross-linked copolymers provide a three-dimensional structure, especially when hydrated.

公开(公告)号：US20210251879A1

公开(公告)日：2021-08-19

申请号：US17175347

申请日：2021-02-12

Applicant: Colgate-Palmolive Company ,  Howard University

Inventor： Tongxin WANG ,  Yanda LEI ,  James W. MITCHELL ,  Lynette ZAIDEL ,  Jian-Hong QIU ,  Mahmoud HASSAN

IPC: A61K8/90 ,  A61Q11/00 ,  C08F293/00 ,  A61K8/21

Abstract: Described herein are block copolymers having hydrophobic blocks and hydrophilic blocks which are effective in binding to the surface of hard tissue; compositions comprising the same, as well as methods of making and using the same.