公开(公告)号：US10335491B2

公开(公告)日：2019-07-02

申请号：US14234321

申请日：2012-07-23

申请人： Hsian-Rong Tseng ,  Hao Wang ,  Kuan-Ju Chen

发明人： Hsian-Rong Tseng ,  Hao Wang ,  Kuan-Ju Chen

IPC分类号： A61K47/40 ,  A61K47/59 ,  C12N15/87 ,  A61K48/00 ,  B82Y5/00 ,  A61K47/60 ,  A61K47/54 ,  A61K47/69

摘要： This invention relates, e.g., to a molecular delivery system comprising A. a substrate having a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the substrate, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises, encapsulated therein, a molecule of interest, and on its surface, multiple copies of second member of the binding pair. Methods of using the molecular delivery system to deliver a molecule of interest to a cell are also described.

公开(公告)号：US20140186426A1

公开(公告)日：2014-07-03

申请号：US14234321

申请日：2012-07-23

申请人： Hsian-Rong Tseng ,  Hao Wang ,  Kuan-Ju Chen

发明人： Hsian-Rong Tseng ,  Hao Wang ,  Kuan-Ju Chen

IPC分类号： A61K47/48

CPC分类号： A61K47/59 ,  A61K47/54 ,  A61K47/595 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6951 ,  A61K47/6957 ,  A61K48/0008 ,  B82Y5/00 ,  C12N15/87

摘要： This invention relates, e.g., to a molecular delivery system comprising A. a substrate having a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the substrate, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises, encapsulated therein, a molecule of interest, and on its surface, multiple copies of second member of the binding pair. Methods of using the molecular delivery system to deliver a molecule of interest to a cell are also described.

摘要翻译： 本发明涉及例如涉及包含A.具有纳米结构化表面区域的底物的分子递送系统，其包含多个纳米结构并且共价连接到所述底物上，多个拷贝的结合对的第一个成员; 和B.至少一种载体纳米颗粒，其包含在其中包封感兴趣的分子，并且在其表面上包含结合对的第二个成员的多个拷贝。 还描述了使用分子递送系统将感兴趣的分子递送至细胞的方法。

公开(公告)号：US09254129B2

公开(公告)日：2016-02-09

申请号：US14025120

申请日：2013-09-12

申请人： Kuan-Ju Chen

发明人： Kuan-Ju Chen

IPC分类号： A61B17/10 ,  A61B17/04

CPC分类号： A61B17/0482 ,  A61B17/0491 ,  A61B2017/0472

摘要： A surgery automatic suturing and knot tying apparatus is to suture and tie knots on a surgical suture having a needle end and a tail end. The surgery automatic suturing and knot tying apparatus comprises a positioning board, a threading module located on the positioning board, and two thread drawing modules and two needle threading arms located on the positioning board. The two needle threading arms wind the surgical suture around the threading module, and collaborate with the two thread drawing modules to draw the surgical suture to make the surgical suture finally be separated from the threading module, thereby can tie knots automatically on the surgical suture to meet use requirements and alleviate the burden of doctors during surgical operation.

摘要翻译： 手术自动缝合和打结装置是在具有针端和尾端的手术缝合线上缝合和结扎结。 手术自动缝合和打结装置包括定位板，位于定位板上的穿线模块和位于定位板上的两个牵引模块和两个针穿线臂。 两针穿线臂将手术缝合线缠绕在螺纹模块上，并与两个牵引模块协作画出手术缝合线，使手术缝合线最终与穿线模块分离，从而可以将结自动扎在外科缝合线上 满足使用要求，减轻外科手术中医生的负担。

公开(公告)号：US20150073443A1

公开(公告)日：2015-03-12

申请号：US14025120

申请日：2013-09-12

申请人： Kuan-Ju Chen

发明人： Kuan-Ju Chen

IPC分类号： A61B17/04

CPC分类号： A61B17/0482 ,  A61B17/0491 ,  A61B2017/0472

摘要： A surgery automatic suturing and knot tying apparatus is to suture and tie knots on a surgical suture having a needle end and a tail end. The surgery automatic suturing and knot tying apparatus comprises a positioning board, a threading module located on the positioning board, and two thread drawing modules and two needle threading arms located on the positioning board. The two needle threading arms wind the surgical suture around the threading module, and collaborate with the two thread drawing modules to draw the surgical suture to make the surgical suture finally be separated from the threading module, thereby can tie knots automatically on the surgical suture to meet use requirements and alleviate the burden of doctors during surgical operation.

摘要翻译： 手术自动缝合和打结装置是在具有针端和尾端的手术缝合线上缝合和结扎结。 手术自动缝合和打结装置包括定位板，位于定位板上的穿线模块和位于定位板上的两个牵引模块和两个针穿线臂。 两针穿线臂将手术缝合线缠绕在螺纹模块上，并与两个牵引模块协作画出手术缝合线，使手术缝合线最终与穿线模块分离，从而可以将结自动扎在外科缝合线上 满足使用要求，减轻外科手术中医生的负担。