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17 条记录 (耗时 0.019 秒)

    Accurate and rapid micromixer for integrated microfluidic devices
    2.
    发明授权
    Accurate and rapid micromixer for integrated microfluidic devices 有权
    精确快速的微型混合器用于集成微流体装置

    公开(公告)号：US09138700B2

    公开(公告)日：2015-09-22

    申请号：US12863276

    申请日：2009-01-21

    申请人： R. Michael Van Dam ,  Kan Liu ,  Kwang-Fu Clifton Shen ,  Hsian-Rong Tseng

    发明人： R. Michael Van Dam ,  Kan Liu ,  Kwang-Fu Clifton Shen ,  Hsian-Rong Tseng

    IPC分类号： B01F13/00 ,  B01F15/04

    CPC分类号： B01F13/0071 ,  B01F15/0462 ,  Y10T137/8593

    摘要： The invention may provide a microfluidic mixer having a droplet generator and a droplet mixer in selective fluid connection with the droplet generator. The droplet generator comprises first and second fluid chambers that are structured to be filled with respective first and second fluids that can each be held in isolation for a selectable period of time. The first and second fluid chambers are further structured to be reconfigured into a single combined chamber to allow the first and second fluids in the first and second fluid chambers to come into fluid contact with each other in the combined chamber for a selectable period of time prior to being brought into the droplet mixer.

    摘要翻译： 本发明可以提供具有液滴发生器和与液滴发生器选择性流体连接的液滴混合器的微流体混合器。 液滴发生器包括第一和第二流体室，其被构造成填充相应的第一和第二流体，每个第一和第二流体可以隔离地保持一段可选择的时间段。 第一和第二流体室被进一步构造成被重新配置成单个组合室，以允许第一和第二流体室中的第一和第二流体在组合室中彼此流体接触一段可选择的时间段 被带入液滴混合器。

    CATALYTIC DELIVERY NANOSUBSTRATES (CDNS) FOR HIGHLY EFFICIENT DELIVERY OF BIOMOLECULES
    3.
    发明申请
    CATALYTIC DELIVERY NANOSUBSTRATES (CDNS) FOR HIGHLY EFFICIENT DELIVERY OF BIOMOLECULES 审中-公开
    催化输送纳米生物分子（CDNS），用于高效分送生物分子

    公开(公告)号：US20140186426A1

    公开(公告)日：2014-07-03

    申请号：US14234321

    申请日：2012-07-23

    申请人： Hsian-Rong Tseng ,  Hao Wang ,  Kuan-Ju Chen

    发明人： Hsian-Rong Tseng ,  Hao Wang ,  Kuan-Ju Chen

    IPC分类号： A61K47/48

    CPC分类号： A61K47/59 ,  A61K47/54 ,  A61K47/595 ,  A61K47/60 ,  A61K47/6923 ,  A61K47/6925 ,  A61K47/6951 ,  A61K47/6957 ,  A61K48/0008 ,  B82Y5/00 ,  C12N15/87

    摘要： This invention relates, e.g., to a molecular delivery system comprising A. a substrate having a nanostructured surface region which comprises a plurality of nanostructures and, covalently attached to the substrate, multiple copies of a first member of a binding pair; and B. at least one vector nanoparticle which comprises, encapsulated therein, a molecule of interest, and on its surface, multiple copies of second member of the binding pair. Methods of using the molecular delivery system to deliver a molecule of interest to a cell are also described.

    摘要翻译： 本发明涉及例如涉及包含A.具有纳米结构化表面区域的底物的分子递送系统，其包含多个纳米结构并且共价连接到所述底物上，多个拷贝的结合对的第一个成员; 和B.至少一种载体纳米颗粒，其包含在其中包封感兴趣的分子，并且在其表面上包含结合对的第二个成员的多个拷贝。 还描述了使用分子递送系统将感兴趣的分子递送至细胞的方法。

    INTEGRATED MICROFLUIDICS FOR HIGHLY PARALLEL SCREENING OF CHEMICAL REACTIONS
    6.
    发明申请
    INTEGRATED MICROFLUIDICS FOR HIGHLY PARALLEL SCREENING OF CHEMICAL REACTIONS 审中-公开
    综合微流化学高效平行筛选化学反应

    公开(公告)号：US20120309648A1

    公开(公告)日：2012-12-06

    申请号：US12667861

    申请日：2008-07-07

    申请人： Hsian-Rong Tseng ,  Jinyi Wang ,  Guodong Sui ,  Kym F. Faull ,  Yanju Wang ,  Wei-Yu Lin

    发明人： Hsian-Rong Tseng ,  Jinyi Wang ,  Guodong Sui ,  Kym F. Faull ,  Yanju Wang ,  Wei-Yu Lin

    IPC分类号： C40B60/12 ,  C40B30/08

    CPC分类号： B01F13/0059 ,  B01F5/102 ,  B01J2219/00315 ,  B01J2219/00317 ,  B01J2219/00353 ,  B01J2219/00389 ,  B01J2219/00479 ,  B01J2219/00702 ,  B01J2219/0072 ,  B01L3/5027 ,  C07C247/10 ,  C07C247/12 ,  C07C247/14 ,  C07C323/59 ,  C07C2601/08 ,  C07C2601/14 ,  C07D211/68 ,  C07D213/42 ,  C07D213/74 ,  C07D215/42 ,  C07D235/14 ,  C07D295/13 ,  C07D295/32 ,  C07D307/52 ,  C07D311/14 ,  C07D317/28 ,  C07D333/20 ,  C40B40/04 ,  C40B50/08 ,  C40B60/12 ,  G01N2035/00544

    摘要： A microfluidic system has a microfluidic mixer and a sample storage component that is in fluid connection with the microfluidic mixer. The microfluidic mixer has a mixing section; a target molecule input section that is in fluid connection with the mixing section, the target molecule input section being suitable to provide a fluid into the mixing section that contains molecules to be targeted by chemical reactions; a first reagent input section that is in fluid connection with the mixing section, the first reagent input section being structured to selectively provide a first reagent selected from a plurality of reagents to test a chemical reaction with the target molecules; a second reagent input section that is in fluid connection with the mixing section, the second reagent input section being structured to selectively provide a second reagent selected from a plurality of reagents to test a chemical reaction with the target molecules and said first reagent; and a neutral fluid input section that is in selectable fluid connection with the sample storage component, the neutral fluid input section being structured to selectively provide a neutral fluid into the sample storage component between successive samples provided to the sample storage component to separate successive samples in a stratified arrangement.

    摘要翻译： 微流体系统具有微流控混合器和与微流体混合器流体连接的样品存储组件。 微流体混合器具有混合部分; 与混合部分流体连接的目标分子输入部分，靶分子输入部分适合于通过化学反应将含有分子的流体提供给混合部分; 与所述混合部分流体连接的第一试剂输入部，所述第一试剂输入部构造成选择性地提供选自多种试剂的第一试剂，以测试与所述靶分子的化学反应; 与所述混合部分流体连接的第二试剂输入部，所述第二试剂输入部构造成选择性地提供选自多种试剂的第二试剂，以测试与所述靶分子和所述第一试剂的化学反应; 以及中性流体输入部分，其与所述样品存储部件可选择性地流体连接，所述中性流体输入部分被构造成在提供给所述样品存储部件的连续样品之间选择性地将中性流体提供到所述样品存储部件中，以将 分层安排。