公开(公告)号：US08470604B2

公开(公告)日：2013-06-25

申请号：US13210738

申请日：2011-08-16

申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： G01N27/333 ,  G01N33/66

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

公开(公告)号：US20130334066A1

公开(公告)日：2013-12-19

申请号：US13904208

申请日：2013-05-29

申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： G01N27/327

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

公开(公告)号：US20090068754A1

公开(公告)日：2009-03-12

申请号：US11875942

申请日：2007-10-21

申请人： Huan-Ping WU ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping WU ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： G01N27/00

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

公开(公告)号：US20190106728A1

公开(公告)日：2019-04-11

申请号：US16221017

申请日：2018-12-14

申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： C12Q1/54 ,  G01N27/327 ,  C12Q1/00 ,  A61B5/1486 ,  A61B5/145

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

公开(公告)号：US20120031776A1

公开(公告)日：2012-02-09

申请号：US13210738

申请日：2011-08-16

申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： G01N27/333 ,  G01N33/66

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

公开(公告)号：US08026104B2

公开(公告)日：2011-09-27

申请号：US11875942

申请日：2007-10-21

申请人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

发明人： Huan-Ping Wu ,  Steven C. Charlton ,  Amy H. Chu ,  Andrew J. Edelbrock ,  Sung-Kwon Jung ,  Dijia Huang

IPC分类号： G01N27/00 ,  G01N27/413

CPC分类号： C12Q1/54 ,  A61B5/14532 ,  A61B5/1455 ,  A61B5/1486 ,  A61B5/1495 ,  C12Q1/004 ,  G01N27/3271 ,  G01N27/3272

摘要： A biosensor system determines an analyte concentration of a biological sample using an electrochemical process without Cottrell decay. The biosensor system generates an output signal having a transient decay, where the output signal is not inversely proportional to the square root of the time. The transient decay is greater or less than the −0.5 decay constant of a Cottrell decay. The transient decay may result from a relatively short incubation period, relatively small sample reservoir volumes, relatively small distances between electrode surfaces and the lid of the sensor strip, and/or relatively short excitations in relation to the average initial thickness of the reagent layer. The biosensor system determines the analyte concentration from the output signal having a transient decay.

摘要翻译： 生物传感器系统使用没有Cottrell衰变的电化学过程来确定生物样品的分析物浓度。 生物传感器系统产生具有瞬时衰减的输出信号，其中输出信号不与时间的平方根成反比。 瞬态衰减大于或小于Cottrell衰变的-0.5衰减常数。 瞬时衰减可能由相对较短的潜伏期，相对小的样品储存容量，电极表面与传感器条的盖之间的相对小的距离和/或相对于试剂层的平均初始厚度的相对短的激发而产生。 生物传感器系统从具有瞬时衰减的输出信号确定分析物浓度。

公开(公告)号：US08871069B2

公开(公告)日：2014-10-28

申请号：US13154088

申请日：2011-06-06

申请人： Amy H. Chu ,  Huan-Ping Wu ,  Boru Zhu

发明人： Amy H. Chu ,  Huan-Ping Wu ,  Boru Zhu

IPC分类号： G01N27/327 ,  G01N33/543 ,  C12Q1/00

CPC分类号： C12Q1/004 ,  G01N33/5438

摘要： A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ΔS value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one ΔS value, where the compensation equation has a R2 value of at least 0.5.

摘要翻译： 公开了一种用于确定样品中分析物浓度的生物传感器系统，其包括用于选择性地进行分析物的氧化还原反应的反应装置和用于测量分析物的氧化还原反应速率的测量装置。 反应装置包括粘合剂，缓冲盐，包含至多20％（w / w）的无机非过渡金属盐和酶体系的介体。 测量装置包括至少两个导体。 测量装置在将样品引入反应装置的最多动力学性能的最大动力学性能下测量来自反应装置的输出信号值，其中输出信号值响应样品中分析物的浓度， 测量装置根据至少一个误差参数确定至少一个＆Dgr S值。 测量装置进一步从包括至少一个参考相关性和至少一个＆Dgr S的值的补偿方程确定样品中的分析物浓度，其中补偿方程的R2值至少为0.5。

公开(公告)号：US20110297540A1

公开(公告)日：2011-12-08

申请号：US13154088

申请日：2011-06-06

申请人： Amy H. Chu ,  Huan-Ping Wu ,  Boru Zhu

发明人： Amy H. Chu ,  Huan-Ping Wu ,  Boru Zhu

IPC分类号： G01N27/327 ,  G01N33/50

CPC分类号： C12Q1/004 ,  G01N33/5438

摘要： A biosensor system for determining the concentration of an analyte in a sample is disclosed that includes a reaction means for selectively performing a redox reaction of an analyte, and a measurement means for measuring a rate of the redox reaction of the analyte. The reaction means includes a binder, a buffer salt, a mediator including at most 20% (w/w) of an inorganic, non-transition metal salt, and an enzyme system. The measurement means includes at least two conductors. The measurement means measures an output signal value from the reaction means at a maximum kinetic performance within at most 7 seconds of introducing a sample to the reaction means, where the output signal value is responsive to the concentration of the analyte in the sample, and the measurement means determines at least one ΔS value responsive to at least one error parameter. The measurement means further determines the analyte concentration in the sample from a compensation equation including at least one reference correlation and the at least one ΔS value, where the compensation equation has a R2 value of at least 0.5.

摘要翻译： 公开了一种用于确定样品中分析物浓度的生物传感器系统，其包括用于选择性地进行分析物的氧化还原反应的反应装置和用于测量分析物的氧化还原反应速率的测量装置。 反应装置包括粘合剂，缓冲盐，包含至多20％（w / w）的无机非过渡金属盐和酶体系的介体。 测量装置包括至少两个导体。 测量装置在将样品引入反应装置的最多动力学性能的最大动力学性能下测量来自反应装置的输出信号值，其中输出信号值响应样品中分析物的浓度， 测量装置根据至少一个误差参数确定至少一个＆Dgr S值。 测量装置进一步从包括至少一个参考相关性和至少一个＆Dgr S的值的补偿方程确定样品中的分析物浓度，其中补偿方程的R2值至少为0.5。

公开(公告)号：US20090152128A1

公开(公告)日：2009-06-18

申请号：US12083952

申请日：2006-11-13

申请人： Amy H. Chu ,  Andrew J. Edelbrock ,  Hope G. Spradlin

发明人： Amy H. Chu ,  Andrew J. Edelbrock ,  Hope G. Spradlin

IPC分类号： G01N33/50 ,  G01N33/52

CPC分类号： C12Q1/26 ,  C12Q1/006

摘要： A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.

摘要翻译： 用于测量体液中分析物浓度的测试传感器试剂包括用于改善测试传感器的稳定性并减少总测定时间的纤维素聚合物。 测试传感器试剂还包括酶，电子转移介体和流变添加剂。

公开(公告)号：US08940153B2

公开(公告)日：2015-01-27

申请号：US12083952

申请日：2006-11-13

申请人： Amy H. Chu ,  Andrew J. Edelbrock ,  Hope G. Spradlin

发明人： Amy H. Chu ,  Andrew J. Edelbrock ,  Hope G. Spradlin

IPC分类号： C12Q1/26 ,  G01N33/50 ,  C12Q1/00

CPC分类号： C12Q1/26 ,  C12Q1/006

摘要： A test sensor reagent for measuring the concentration of analytes in body fluids includes cellulose polymers for improving the stability of the test sensor and reducing the total assay time. The test sensor reagent also includes an enzyme, an electron transfer mediator and a rheological additive.

摘要翻译： 用于测量体液中分析物浓度的测试传感器试剂包括用于改善测试传感器的稳定性并减少总测定时间的纤维素聚合物。 测试传感器试剂还包括酶，电子转移介体和流变添加剂。