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    METHOD FOR THE PRODUCTION OF D,L-METHIONINE
    4.
    发明申请
    METHOD FOR THE PRODUCTION OF D,L-METHIONINE 审中-公开
    生产D，L-甲硫氨酸的方法

    公开(公告)号：US20150197489A1

    公开(公告)日：2015-07-16

    申请号：US14671435

    申请日：2015-03-27

    申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    IPC分类号： C07C319/20

    CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

    摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercapto-propionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

    摘要翻译： 提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈是通过在多基团反应器的主反应区中作为催化剂的碱作为催化剂使3-甲基巯基丙醛与氰化氢反应得到的。 残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

    METHOD FOR THE PRODUCTION OF 2-HYDROXY-4-(METHYLTHIO)BUTYRONITRILE FROM 3-(METHYLTHIO)PROPANAL AND HYDROGEN CYANIDE
    5.
    发明申请
    METHOD FOR THE PRODUCTION OF 2-HYDROXY-4-(METHYLTHIO)BUTYRONITRILE FROM 3-(METHYLTHIO)PROPANAL AND HYDROGEN CYANIDE 有权
    从3-（甲基）丙醛和氢氰化物生产2-羟基-4-（甲基）苯并呋喃的方法

    公开(公告)号：US20120215022A1

    公开(公告)日：2012-08-23

    申请号：US13402041

    申请日：2012-02-22

    申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    IPC分类号： C07C51/08 ,  C07C253/00

    CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

    摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

    摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

    Method for the production of D,L-methionine
    7.
    发明授权
    Method for the production of D,L-methionine 有权
    生产D，L-甲硫氨酸的方法

    公开(公告)号：US09206121B2

    公开(公告)日：2015-12-08

    申请号：US14671435

    申请日：2015-03-27

    申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    IPC分类号： C07C319/20 ,  C07C51/08 ,  C07C253/00

    CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

    摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercaptopropionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

    摘要翻译： 提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈通过3-甲基巯基丙醛与氰化氢在碱性作为催化剂存在下在多区反应器的主反应区中反应得到。 残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

    Method for the production of 2-hydroxy-4-(methylthio)butyronitrile from 3-(methylthio)propanal and hydrogen cyanide
    8.
    发明授权
    Method for the production of 2-hydroxy-4-(methylthio)butyronitrile from 3-(methylthio)propanal and hydrogen cyanide 有权
    从3-（甲硫基）丙醛和氰化氢生产2-羟基-4-（甲硫基）丁腈的方法

    公开(公告)号：US08729288B2

    公开(公告)日：2014-05-20

    申请号：US13402041

    申请日：2012-02-22

    申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

    IPC分类号： C07C253/00 ,  C07C51/08

    CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

    摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

    摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。