公开(公告)号：US07833508B2

公开(公告)日：2010-11-16

申请号：US12501114

申请日：2009-07-10

申请人： Hubert Redlingshöfer ,  Jan-Olaf Barth ,  Caspar-Heinrich Finkeldei ,  Hans Joachim Hasselbach ,  Stephan Kretz ,  Harald Heinzel ,  Christoph Weckbecker

发明人： Hubert Redlingshöfer ,  Jan-Olaf Barth ,  Caspar-Heinrich Finkeldei ,  Hans Joachim Hasselbach ,  Stephan Kretz ,  Harald Heinzel ,  Christoph Weckbecker

IPC分类号： B01J10/00 ,  C01B17/16

CPC分类号： B01J8/025 ,  B01J10/005 ,  B01J19/246 ,  C01B17/162

摘要： The invention relates to a reaction vessel in which hydrogen sulphide is prepared from sulphur and hydrogen, wherein the reaction vessel consists partly or entirely of a material which is resistant to the reaction mixture, its compounds or elements and retains its resistance even at high temperatures.

摘要翻译： 本发明涉及一种其中由硫和氢制备硫化氢的反应容器，其中反应容器部分或全部由对反应混合物，其化合物或元素具有抗性并且甚至在高温下也保持其电阻的材料组成。

公开(公告)号：US20100015037A1

公开(公告)日：2010-01-21

申请号：US12501114

申请日：2009-07-10

申请人： Hurbert Redlingshöfer ,  Jan-Olaf Barth ,  Caspar-Heinrich Finkeldei ,  Hans Joachim Hasselbach ,  Stephan Kretz ,  Harald Heinzel ,  Christoph Weckbecker

发明人： Hurbert Redlingshöfer ,  Jan-Olaf Barth ,  Caspar-Heinrich Finkeldei ,  Hans Joachim Hasselbach ,  Stephan Kretz ,  Harald Heinzel ,  Christoph Weckbecker

IPC分类号： C01B17/16 ,  B01J7/00

CPC分类号： B01J8/025 ,  B01J10/005 ,  B01J19/246 ,  C01B17/162

摘要： The invention relates to a reaction vessel in which hydrogen sulphide is prepared from sulphur and hydrogen, wherein the reaction vessel consists partly or entirely of a material which is resistant to the reaction mixture, its compounds or elements and retains its resistance even at high temperatures.

摘要翻译： 本发明涉及一种其中由硫和氢制备硫化氢的反应容器，其中反应容器部分或全部由对反应混合物，其化合物或元素具有抗性并且甚至在高温下也保持其电阻的材料组成。

公开(公告)号：US20150197489A1

公开(公告)日：2015-07-16

申请号：US14671435

申请日：2015-03-27

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C319/20

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercapto-propionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈是通过在多基团反应器的主反应区中作为催化剂的碱作为催化剂使3-甲基巯基丙醛与氰化氢反应得到的。 残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US08759592B2

公开(公告)日：2014-06-24

申请号：US14067098

申请日：2013-10-30

申请人： Caspar Heinrich Finkeldei ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

发明人： Caspar Heinrich Finkeldei ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

IPC分类号： C07C319/20

CPC分类号： C07C319/20 ,  C07C319/16 ,  C07C323/22

摘要： A process for preparing methylmercaptopropionaldehyde in a single reaction unit, is provided. According to the preferred embodiment, the process comprises, simultaneously contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reactive absorber; absorbing the acrolein from the gaseous mixture into the liquid mixture; reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde; removing gaseous impurities and by-products from the liquid mixture; and separating the obtained methylmercaptopropionaldehyde product from the reactive absorber, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reactive absorber; wherein the methyl mercaptan optionally comprises dimethyl sulfide or dimethyl ether.

摘要翻译： 提供了在单个反应单元中制备甲基巯基丙醛的方法。 根据优选实施方案，该方法包括同时使包含丙烯醛的气体混合物与包含甲基巯基丙醛，甲硫醇，催化剂和甲基巯基丙醛甲硫基缩醛的液体混合物接触; 将丙烯醛从气态混合物吸收到液体混合物中; 使吸收的丙烯醛与甲基硫醇或甲基巯基丙醛甲基硫代缩甲醛反应，得到巯基丙醛甲缩醛; 从液体混合物中除去气态杂质和副产物; 并将所获得的甲基巯基丙醛产物与反应性吸收剂分离，将一部分分离产物导入储存或进一步加工并将剩余部分再循环至反应性吸收剂; 其中甲硫醇任选地包括二甲基硫醚或二甲醚。

公开(公告)号：US20120215022A1

公开(公告)日：2012-08-23

申请号：US13402041

申请日：2012-02-22

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C51/08 ,  C07C253/00

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US08624066B2

公开(公告)日：2014-01-07

申请号：US13337434

申请日：2011-12-27

申请人： Caspar Heinrich Finkeldei ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

发明人： Caspar Heinrich Finkeldei ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

IPC分类号： C07C319/18

CPC分类号： C07C319/20 ,  C07C319/16 ,  C07C323/22

摘要： A process for preparing methylmercaptopropionaldehyde in a single reaction unit, is provided. According to the preferred embodiment, the process comprises, simultaneously contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reactive absorber; absorbing the acrolein from the gaseous mixture into the liquid mixture; reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde; removing gaseous impurities and by-products from the liquid mixture; and separating the obtained methylmercaptopropionaldehyde product from the reactive absorber, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reactive absorber; wherein the methyl mercaptan optionally comprises dimethyl sulfide or dimethyl ether.

摘要翻译： 提供了在单个反应单元中制备甲基巯基丙醛的方法。 根据优选实施方案，该方法包括同时使包含丙烯醛的气体混合物与包含甲基巯基丙醛，甲硫醇，催化剂和甲基巯基丙醛甲硫基缩醛的液体混合物接触; 将丙烯醛从气态混合物吸收到液体混合物中; 使吸收的丙烯醛与甲基硫醇或甲基巯基丙醛甲基硫代缩甲醛反应，得到甲基巯基丙醛; 从液体混合物中除去气态杂质和副产物; 并将所获得的甲基巯基丙醛产物与反应性吸收剂分离，将一部分分离产物导入储存或进一步加工并将剩余部分再循环至反应性吸收剂; 其中甲硫醇任选地包括二甲基硫醚或二甲醚。

公开(公告)号：US20120165573A1

公开(公告)日：2012-06-28

申请号：US13337434

申请日：2011-12-27

申请人： Caspar Heinrich FINKELDEI ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

发明人： Caspar Heinrich FINKELDEI ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

IPC分类号： C07C319/18

CPC分类号： C07C319/20 ,  C07C319/16 ,  C07C323/22

摘要： A process for preparing methylmercaptopropionaldehyde in a single reaction unit, is provided. According to the preferred embodiment, the process comprises, simultaneously contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reactive absorber; absorbing the acrolein from the gaseous mixture into the liquid mixture; reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde; removing gaseous impurities and by-products from the liquid mixture; and separating the obtained methylmercaptopropionaldehyde product from the reactive absorber, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reactive absorber; wherein the methyl mercaptan optionally comprises dimethyl sulfide or dimethyl ether.

摘要翻译： 提供了在单个反应单元中制备甲基巯基丙醛的方法。 根据优选实施方案，该方法包括同时使包含丙烯醛的气体混合物与包含甲基巯基丙醛，甲硫醇，催化剂和甲基巯基丙醛甲硫基缩醛的液体混合物接触; 将丙烯醛从气态混合物吸收到液体混合物中; 使吸收的丙烯醛与甲基硫醇或甲基巯基丙醛甲基硫代缩甲醛反应，得到甲基巯基丙醛; 从液体混合物中除去气态杂质和副产物; 并将所获得的甲基巯基丙醛产物与反应性吸收剂分离，将一部分分离产物导入储存或进一步加工并将剩余部分再循环至反应性吸收剂; 其中甲硫醇任选地包括二甲基硫醚或二甲醚。

公开(公告)号：US09206121B2

公开(公告)日：2015-12-08

申请号：US14671435

申请日：2015-03-27

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C319/20 ,  C07C51/08 ,  C07C253/00

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method to produce D,L-Methionine from 2-hydroxy-4-(methylthio)butyronitrile by reaction with ammonia, optionally in the presence of carbon dioxide, is provided. The 2-hydroxy-4-(methylthio)butyronitrile is obtained by reaction of 3-methylmercaptopropionaldehyde with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of a multizone reactor. Residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了通过与氨反应，任选在二氧化碳存在下，由2-羟基-4-（甲硫基）丁腈生成D，L-甲硫氨酸的方法。 2-羟基-4-（甲硫基）丁腈通过3-甲基巯基丙醛与氰化氢在碱性作为催化剂存在下在多区反应器的主反应区中反应得到。 残留的气态氰化氢从主反应区除去反应器的吸收和后反应区，其包含3-甲基巯基丙醛和催化剂的混合物; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US08729288B2

公开(公告)日：2014-05-20

申请号：US13402041

申请日：2012-02-22

申请人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

发明人： Dieter Buss ,  Martin Steurenthaler ,  Michael R. Rinner ,  Stephan Kretz ,  Hans Joachim Hasselbach ,  Caspar-Heinrich Finkeldei ,  Martin Koerfer ,  Pablo Zacchi

IPC分类号： C07C253/00 ,  C07C51/08

CPC分类号： C07C319/20 ,  C07C323/60 ,  C07C323/58 ,  C07C323/52

摘要： A method for the production of 2-hydroxy-4-(methylthio)butyronitrile having good storage stability in a multi-zone reactor, is provided. 3-methylmercaptopropionaldehyde is reacted with hydrogen cyanide in the presence of a base as catalyst in a main reaction zone of the multizone reactor to form a reaction mixture comprising the 2-hydroxy-4-(methylthio)butyronitrile, unreacted 3-methylmercaptopropionaldehyde, the catalyst and residual amounts of gaseous hydrogen cyanide. The residual gaseous hydrogen cyanide is removed from the main reaction zone to an absorption and post-reaction zone of the reactor which comprises a mixture of 3-methylmercaptopropionaldehyde and the catalyst; and the gaseous hydrogen cyanide is further reacted with the 3-methylmercaptopropionaldehyde in the absorption and post reaction zone. A molar ratio of hydrogen cyanide to 3-(methylthio)propanal in the main reaction zone is from 0.98 to 1.03.

摘要翻译： 提供了一种在多区域反应器中制备具有良好储存稳定性的2-羟基-4-（甲硫基）丁腈的方法。 在多基团反应器的主反应区中，3-甲基巯基丙醛与作为催化剂的碱存在下，与氰化氢反应形成包含2-羟基-4-（甲硫基）丁腈，未反应的3-甲基巯基丙醛，催化剂 和残留量的氰化氢气体。 将残留的气态氰化氢从主反应区移除到包含3-甲基巯基丙醛和催化剂的混合物的反应器的吸收和后反应区域; 并且氰化氢气体在吸收和后反应区域中与3-甲基巯基丙醛进一步反应。 主反应区氰化氢与3-（甲硫基）丙醛的摩尔比为0.98-1.03。

公开(公告)号：US20140051890A1

公开(公告)日：2014-02-20

申请号：US14067098

申请日：2013-10-30

申请人： Caspar Heinrich FINKELDEI ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

发明人： Caspar Heinrich FINKELDEI ,  Pablo Zacchi ,  Benjamin Fonfe ,  Stephan Kretz ,  Martin Koerfer ,  Hans Joachim Hasselbach ,  Wolfgang Boeck

IPC分类号： C07C319/20

CPC分类号： C07C319/20 ,  C07C319/16 ,  C07C323/22

摘要： A process for preparing methylmercaptopropionaldehyde in a single reaction unit, is provided. According to the preferred embodiment, the process comprises, simultaneously contacting a gaseous mixture comprising acrolein with a liquid mixture comprising methylmercaptopropionaldehyde, methyl mercaptan, a catalyst and methylmercaptopropionaldehyde methyl thiohemiacetal in the reactive absorber; absorbing the acrolein from the gaseous mixture into the liquid mixture; reacting the absorbed acrolein with the methyl mercaptan or the methylmercaptopropionaldehyde methyl thiohemiacetal to obtain methylmercapto-propionaldehyde; removing gaseous impurities and by-products from the liquid mixture; and separating the obtained methylmercaptopropionaldehyde product from the reactive absorber, directing a portion of the separated product to storage or further processing and recycling the remaining portion to the reactive absorber; wherein the methyl mercaptan optionally comprises dimethyl sulfide or dimethyl ether.

摘要翻译： 提供了在单个反应单元中制备甲基巯基丙醛的方法。 根据优选实施方案，该方法包括同时使包含丙烯醛的气体混合物与包含甲基巯基丙醛，甲硫醇，催化剂和甲基巯基丙醛甲硫基缩醛的液体混合物接触; 将丙烯醛从气态混合物吸收到液体混合物中; 使吸收的丙烯醛与甲基硫醇或甲基巯基丙醛甲基硫代缩甲醛反应，得到巯基丙醛甲缩醛; 从液体混合物中除去气态杂质和副产物; 并将所获得的甲基巯基丙醛产物与反应性吸收剂分离，将一部分分离产物导入储存或进一步加工并将剩余部分再循环至反应性吸收剂; 其中甲硫醇任选地包括二甲基硫醚或二甲醚。