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公开(公告)号：US20120101031A1
公开(公告)日：2012-04-26
申请号：US13154721
申请日：2011-06-07
申请人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
发明人： Hui-Ju Chen , Keith F. McDaniel , Brian E. Green , Jason P. Shanley , Albert W. Kruger , Jorge Gandarilla , Dennie S. Welch , Russell D. Cink , Steven C. Cullen , Yonghua Gai , Guoqiang Wang , Yat Sun Or
CPC分类号： C07K5/081 , C07D487/04
摘要： The present invention relates to novel macrocyclic compounds and methods of treating a hepatitis C infection in a subject in need of such therapy with said macrocyclic compounds. The present invention further relates to pharmaceutical compositions comprising the compounds of the present invention, or pharmaceutically acceptable salts, esters, or prodrugs thereof, in combination with a pharmaceutically acceptable carrier or excipient.
摘要翻译： 本发明涉及新的大环化合物和在需要用所述大环化合物进行这种治疗的受试者中治疗丙型肝炎感染的方法。 本发明还涉及包含本发明化合物或其药学上可接受的盐，酯或前药与药学上可接受的载体或赋形剂组合的药物组合物。
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公开(公告)号：US20100298292A1
公开(公告)日：2010-11-25
申请号：US12784624
申请日：2010-05-21
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： A61K31/554 , C07D487/04 , A61K31/55 , C07D491/044 , A61K31/407 , C07D513/04 , A61P25/00 , A61P3/04 , A61P3/10 , A61P1/04 , A61P17/06
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：US09187483B2
公开(公告)日：2015-11-17
申请号：US12784624
申请日：2010-05-21
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： A61K31/55 , C07D487/04 , C07D491/04 , C07D495/04
CPC分类号： C07D513/04 , C07D487/04 , C07D491/04 , C07D491/044 , C07D495/04 , C07D495/16
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：US08846951B2
公开(公告)日：2014-09-30
申请号：US12950029
申请日：2010-11-19
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： C07D491/12 , C07D498/12 , C07D487/12 , A61K31/407 , A61K31/553 , A61K31/554 , A61K31/55 , C07D513/04 , C07D495/04 , C07D487/04 , C07D491/04
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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公开(公告)号：US20110118231A1
公开(公告)日：2011-05-19
申请号：US12950029
申请日：2010-11-19
申请人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
发明人： Irini Akritopoulou-Zanze , Wilfried Braje , Stevan W. Djuric , Noel S. Wilson , Sean C. Turner , Albert W. Kruger , Ana-Lucia Relo , Shashank Shekhar , Dennie S. Welch , Hongyu Zhao , Jorge Gandarilla , Alan F. Gasiecki , Huanqiu Li , Christina M. Thompson , Min Zhang
IPC分类号： A61K31/554 , C07D487/04 , C07D491/044 , C07D513/04 , A61K31/55 , A61K31/407 , A61P25/28 , A61P25/00 , A61P25/18 , A61P25/24 , A61P25/22 , A61P25/16 , A61P25/08 , A61P25/06 , A61P25/30 , A61P3/04 , A61P3/10 , A61P9/12 , A61P29/00 , A61P15/10 , A61P15/00 , A61P17/06
CPC分类号： C07D487/04 , C07D491/04 , C07D495/04 , C07D513/04
摘要： The present application relates to aryl- and heteroaryl-fused decahydropyrroloazepine, octahydrooxepinopyrrole, octahydropyrrolothiazepine dioxide, decahydrocyclohepta[c]pyrrole, and octahydrocyclohepta[c]pyrrole derivatives of formula (I) wherein R1, R2, R3, R4, R5, A, Y1, Y2, and Y3 are as defined in the specification. The present application also relates to compositions comprising such compounds, processes for making such compounds, and methods of treating disease conditions using such compounds and compositions, and methods for identifying such compounds.
摘要翻译： 本申请涉及式（I）的芳基 - 和杂芳基 - 稠合十氢吡咯并氮平，二氢八氢化吡咯并噻吩，十氢环庚三烯并[c]吡咯和八氢环庚三烯并[c]吡咯衍生物，其中R1，R2，R3，R4，R5，A，Y1 ，Y2和Y3如说明书中所定义。 本申请还涉及包含这些化合物的组合物，制备此类化合物的方法，以及使用这些化合物和组合物治疗疾病状况的方法，以及鉴定这些化合物的方法。
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6.发明申请Crystalline N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide ethanolates 审中-公开结晶N-（2 - （（4-羟基苯基）氨基）吡啶-3-基）-4-甲氧基苯磺酰胺乙醇化物公开(公告)号：US20070021471A1
公开(公告)日：2007-01-25
申请号：US11332274
申请日：2006-01-13
申请人： Jorge Gandarilla , Karthryn Schardt , John Quick
发明人： Jorge Gandarilla , Karthryn Schardt , John Quick
IPC分类号： A61K31/44 , C07D213/72
CPC分类号： C07D213/76
摘要： Ethanolates of N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide, ways to make them, compositions containing them or made with them, and methods of treating diseases using them or drugs made from them. are disclosed.
摘要翻译： N-（2 - （（4-羟基苯基）氨基）吡啶-3-基）-4-甲氧基苯磺酰胺的制备方法，含有它们或用它们制备的组合物，以及使用它们治疗疾病的方法或由 他们。 被披露。
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7.发明授权Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile 有权（2S，5R）-5-乙炔基-1- {N-（4-甲基-1-（4-羧基 - 吡啶-2-基）哌啶-4-基）甘氨酰基}吡咯烷-2-甲腈公开(公告)号：US09260411B2
公开(公告)日：2016-02-16
申请号：US11779936
申请日：2007-07-19
申请人： Todd S. McDermott , Seble H. Wagaw , Kenneth M. Engstrom , Jorge Gandarilla , Albert Kruger , Michael J. Rozema , Michael G. Fickes , Steven J. Wittenberger , Lakshmi Bhagavatula , Thomas B. Borchardt
发明人： Todd S. McDermott , Seble H. Wagaw , Kenneth M. Engstrom , Jorge Gandarilla , Albert Kruger , Michael J. Rozema , Michael G. Fickes , Steven J. Wittenberger , Lakshmi Bhagavatula , Thomas B. Borchardt
IPC分类号： C07D401/14 , C07D401/04
CPC分类号： C07D401/14 , C07D207/16 , C07D213/803 , C07D401/04 , C07F7/0803
摘要： A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
摘要翻译： 制备（2S，5R）-5-乙炔基-1- {N-（4-甲基-1-（4-羧基 - 吡啶-2-基）哌啶-4-基）甘氨酰基}吡咯烷-2-甲腈 及其盐，以及该方法中使用的中间体。
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8.发明申请Synthesis of (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile 有权（2S，5R）-5-乙炔基-1- {N-（4-甲基-1-（4-羧基 - 吡啶-2-基）哌啶-4-基）甘氨酰基}吡咯烷-2-甲腈公开(公告)号：US20080058528A1
公开(公告)日：2008-03-06
申请号：US11779936
申请日：2007-07-19
申请人： Todd McDermott , Seble Wagaw , Kenneth Engstrom , Jorge Gandarilla , Albert Kruger , Michael Rozema , Michael Fickes , Steven Wittenberger , Lakshmi Bhagavatula , Thomas Borchardt
发明人： Todd McDermott , Seble Wagaw , Kenneth Engstrom , Jorge Gandarilla , Albert Kruger , Michael Rozema , Michael Fickes , Steven Wittenberger , Lakshmi Bhagavatula , Thomas Borchardt
IPC分类号： C07D221/00 , C07D207/04 , C07F7/02 , C07D213/02
CPC分类号： C07D401/14 , C07D207/16 , C07D213/803 , C07D401/04 , C07F7/0803
摘要： A process for making (2S,5R)-5-ethynyl-1-{N-(4-methyl-1-(4-carboxy-pyridin-2-yl)piperidin-4-yl)glycyl}pyrrolidine-2-carbonitrile and salts thereof, and intermediates used in the process are disclosed.
摘要翻译： 制备（2S，5R）-5-乙炔基-1- {N-（4-甲基-1-（4-羧基 - 吡啶-2-基）哌啶-4-基）甘氨酰基}吡咯烷-2-甲腈 及其盐，以及该方法中使用的中间体。
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9.发明申请Crystalline N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide methanolates 审中-公开结晶N-（2 - （（4-羟基苯基）氨基）吡啶-3-基）-4-甲氧基苯磺酰胺甲醇化物公开(公告)号：US20070021470A1
公开(公告)日：2007-01-25
申请号：US11331535
申请日：2006-01-13
申请人： Jorge Gandarilla , Kathryn Schardt , John Quick
发明人： Jorge Gandarilla , Kathryn Schardt , John Quick
IPC分类号： A61K31/44 , C07D213/78
CPC分类号： C07D213/76
摘要： Methanolates of N-(2-((4-Hydroxyphenyl)amino)pyridin-3-yl)-4-methoxybenzenesulfonamide, ways to make them, compositions containing them or made with them, and methods of treating diseases using them or drugs made from them are disclosed.
摘要翻译： N-（2 - （（4-羟基苯基）氨基）吡啶-3-基）-4-甲氧基苯磺酰胺，制备它们的方法，含有它们或用它们制备的组合物的甲醇盐，以及使用它们治疗疾病的方法或由 他们被披露。
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