公开(公告)号：US07569127B1

公开(公告)日：2009-08-04

申请号：US11044494

申请日：2005-01-27

Applicant: Hyoung Jin Cho

Inventor： Hyoung Jin Cho

IPC: B81C3/00 ,  C12M1/00

CPC classification number: B81B7/0061 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2300/0874 ,  B81B2207/07 ,  Y10T137/212 ,  Y10T137/2224

Abstract: A one-piece, microfluidic package with standardized multiple ports allows devices to be connected in series without resorting to extra tubing connections or bonding processes. The one-piece construction consists of microfluidic channels that can be connected to fluid reservoirs and other fluidic components fabricated with interconnecting and interlocking ports. The size of the friction-fit interlocking ports is designed such that the smaller male port fits snugly into the larger female port in a manner that is leak-free and adhesive-free. The friction-fit ports can also be reconfigured. Thus, the interconnection of microfluidic packages can be in an extended series including connections to sensors and devices such as a bio/biochemical/chemical sensor chip, a dielectrophoretic manipulator chip, and a microfluidic reactor chip.

Abstract translation: 具有标准化多端口的单件式微流体封装允许器件串联连接，而不需要额外的管道连接或接合工艺。 一体式结构由微流体通道组成，其可连接到流体储存器以及由互连和互锁端口制造的其它流体部件。 摩擦配合互锁端口的尺寸设计成使得较小的公口以无泄漏和无粘合剂的方式紧密地配合到较大的阴端口中。 摩擦配合端口也可以重新配置。 因此，微流体封装的互连可以是延伸的系列，包括与传感器和器件的连接，例如生物/生物化学/化学传感器芯片，介电电泳机械手芯片和微流控反应堆芯片。

公开(公告)号：US08430558B1

公开(公告)日：2013-04-30

申请号：US12553241

申请日：2009-09-03

Applicant: Ehsan Yakhshi Tafti ,  Hyoung Jin Cho ,  Ranganathan Kumar

Inventor： Ehsan Yakhshi Tafti ,  Hyoung Jin Cho ,  Ranganathan Kumar

IPC: B01F13/00

CPC classification number: B01F5/0603 ,  B01F5/065 ,  B01F5/0655 ,  B01F13/0059 ,  B01F13/0061 ,  B01F13/0064 ,  B01F2215/0431 ,  B81B1/00 ,  Y10S366/03

Abstract: A micromixing apparatus includes a mixing microchannel formed in a top surface of a substrate having a channel length and a variable channel width defined by a first sidewall surface and an opposing second sidewall surface. The channel width varies from a minimum channel width h to a maximum channel width H in a ratio of H:h≧1.1:1.0. A first inlet is for injecting a first fluid into the mixing microchannel and a second inlet for injecting a second fluid into the mixing microchannel. The first and second fluid flow in a flow direction in the mixing microchannel along the channel length. The first sidewall surface includes first curved surface portions and the second sidewall surface includes a second curved surface portions. The plurality of first curved surface portions and plurality of second curved surface portions are non-overlapping to provide the variable channel width.

Abstract translation: 微混合装置包括形成在衬底的顶表面中的混合微通道，其具有通道长度和由第一侧壁表面和相对的第二侧壁表面限定的可变通道宽度。 通道宽度以H:H> = 1.1:1.0的比率从最小通道宽度h到最大通道宽度H变化。 第一入口用于将第一流体注入到混合微通道中，第二入口用于将第二流体注入到混合微通道中。 第一和第二流体沿着通道长度在混合微通道中沿流动方向流动。 第一侧壁表面包括第一弯曲表面部分，第二侧壁表面包括第二弯曲表面部分。 多个第一弯曲表面部分和多个第二弯曲表面部分不重叠以提供可变通道宽度。

公开(公告)号：US20090244542A1

公开(公告)日：2009-10-01

申请号：US12321098

申请日：2009-01-15

Applicant: Hyoung Jin Cho ,  Hyungseok Bang ,  Patrick Li Kam Wa

Inventor： Hyoung Jin Cho ,  Hyungseok Bang ,  Patrick Li Kam Wa

IPC: G01N21/55

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N2021/0346

Abstract: An integrated optical waveguide type surface plasmon resonance (SPR) sensor having an optical waveguide with a corresponding SPR sensing area, photodetectors, and wavelength tunable laser or any kind of external tunable laser source/coupler formed on a substrate. In an embodiment, the laser is a wavelength tunable laser and optionally, the integrated device may include a power source on the substrate for providing a electric power to the wavelength tunable laser and the photodetectors, or a circuit for signal processing, or a microfluidic structure for routing a target sample to the SPR sensor area. The microfluidic structure optionally includes a mixer or a reaction chamber for mixing and allowing a physical or chemical reaction to occur, respectively. In an embodiment, plural planar integrated optical waveguide type SPR sensors may be fabricated on a substrate to form an array of SPR sensors.

Abstract translation: 一种集成的光波导型表面等离子体共振（SPR）传感器，其具有具有相应的SPR感测区域的光波导，光电探测器和波长可调激光器或形成在衬底上的任何种类的外部可调激光源/耦合器。 在一个实施例中，激光器是波长可调激光器，并且可选地，集成器件可以包括在衬底上的用于向波长可调谐激光器和光电探测器提供电力的电源，或用于信号处理的电路或微流体结构 用于将目标样本路由到SPR传感器区域。 微流体结构任选地包括混合器或用于混合并允许发生物理或化学反应的反应室。 在一个实施例中，可以在基板上制造多个平面集成光波导型SPR传感器，以形成SPR传感器阵列。

公开(公告)号：US07483140B1

公开(公告)日：2009-01-27

申请号：US11297750

申请日：2005-12-08

Applicant: Hyoung Jin Cho ,  Hyungseok Bang ,  Patrick Li Kam Wa

Inventor： Hyoung Jin Cho ,  Hyungseok Bang ,  Patrick Li Kam Wa

IPC: G01N21/55

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N2021/0346

Abstract: An integrated optical waveguide type surface plasmon resonance (SPR) sensor having an optical waveguide with a corresponding SPR sensing area, photodetectors, and wavelength tunable laser or any kind of external tunable laser source/coupler formed on a substrate. In an embodiment, the laser is a wavelength tunable laser and optionally, the integrated device may include a power source on the substrate for providing a electric power to the wavelength tunable laser and the photodetectors, or a circuit for signal processing, or a microfluidic structure for routing a target sample to the SPR sensor area. The microfluidic structure optionally includes a mixer or a reaction chamber for mixing and allowing a physical or chemical reaction to occur, respectively. In an embodiment, plural planar integrated optical waveguide type SPR sensors may be fabricated on a substrate to form an array of SPR sensors.

Abstract translation: 一种集成的光波导型表面等离子体共振（SPR）传感器，其具有具有相应的SPR感测区域的光波导，光电探测器和波长可调激光器或形成在衬底上的任何种类的外部可调激光源/耦合器。 在一个实施例中，激光器是波长可调激光器，并且可选地，集成器件可以包括在衬底上的用于向波长可调谐激光器和光电探测器提供电力的电源，或用于信号处理的电路或微流体结构 用于将目标样本路由到SPR传感器区域。 微流体结构任选地包括混合器或用于混合并允许发生物理或化学反应的反应室。 在一个实施例中，可以在基板上制造多个平面集成光波导型SPR传感器，以形成SPR传感器阵列。

公开(公告)号：US08057724B2

公开(公告)日：2011-11-15

申请号：US12683215

申请日：2010-01-06

Applicant: Hyoung Jin Cho ,  Shekhar Halakatti ,  Anjum Mehta

Inventor： Hyoung Jin Cho ,  Shekhar Halakatti ,  Anjum Mehta

IPC: B28B23/00

CPC classification number: B81B7/0061 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B81B2207/07 ,  G01N33/1806 ,  Y10T137/212 ,  Y10T137/2224

Abstract: A disposable microsensor is designed, fabricated and tested for standard BOD (Biochemical Oxygen Demand) measurements. A transparent Cyclic Olefin Copolymer (COC) substrate is used for sensor fabrication. Standard lithographic procedures in addition to techniques like screen printing and electroplating are used to fabricate the sensor. A microbial strain of Trichosporon Cutaneum is immobilized over one pair of sensor electrodes while the other is used as a reference. Depending on the respiratory activities of the microbial strain in different samples, the BOD values of the samples can be measured in terms of difference between the output signals. The sensor layer is attached to an injection-molded passive microfluidic channel on the top. Advantages of the BOD microsensor include, but are not limited to, fast BOD measurement, disposability because of its low cost, chemically inert polymer substrate, flow-through sample injection scheme and integration of on-chip optics.

Abstract translation: 一次性微量传感器被设计，制造和测试用于标准BOD（生化需氧量）测量。 透明的环烯烃共聚物（COC）基底用于传感器制造。 除了丝网印刷和电镀之类的技术之外，还使用标准平版印刷术来制造传感器。 将Trichosporon Cutaneum的微生物菌株固定在一对传感器电极上，另一个用作参考。 取决于不同样品中微生物菌株的呼吸活动，样品的BOD值可以根据输出信号之间的差异来测量。 传感器层连接到顶部的注射成型的无源微流体通道。 BOD微传感器的优点包括但不限于快速BOD测量，可替换性，因为其低成本，化学惰性聚合物基材，流通样品注入方案和片上光学器件的集成。

公开(公告)号：US07988902B1

公开(公告)日：2011-08-02

申请号：US12459931

申请日：2009-07-09

Applicant: Hyoung Jin Cho

Inventor： Hyoung Jin Cho

IPC: B81C1/00

CPC classification number: B81B7/0061 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0816 ,  B01L2300/0874 ,  B81B2207/07 ,  Y10T137/212 ,  Y10T137/2224

Abstract: A one-piece, microfluidic package with standardized multiple ports allows devices to be connected in series without resorting to extra tubing connections or bonding processes. The one-piece construction consists of microfluidic channels that can be connected to fluid reservoirs and other fluidic components fabricated with interconnecting and interlocking ports. The size of the friction-fit interlocking ports is designed such that the smaller male port fits snugly into the larger female port in a manner that is leak-free and adhesive-free. The friction-fit ports can also be reconfigured. Thus, the interconnection of microfluidic packages can be in an extended series including connections to sensors and devices such as a bio/biochemical/chemical sensor chip, a dielectrophoretic manipulator chip, and a microfluidic reactor chip.

Abstract translation: 具有标准化多端口的单件式微流体封装允许器件串联连接，而不需要额外的管道连接或接合工艺。 一体式结构由微流体通道组成，其可连接到流体储存器以及由互连和互锁端口制造的其它流体部件。 摩擦配合互锁端口的尺寸设计成使得较小的公口以无泄漏和无粘合剂的方式紧密地配合到较大的阴端口中。 摩擦配合端口也可以重新配置。 因此，微流体封装的互连可以是延伸的系列，包括与传感器和器件的连接，例如生物/生物化学/化学传感器芯片，介电电泳机械手芯片和微流控反应堆芯片。

公开(公告)号：US07920267B2

公开(公告)日：2011-04-05

申请号：US12321098

申请日：2009-01-15

Applicant: Hyoung Jin Cho ,  Hyungseok Bang ,  Patrick Li Kam Wa

Inventor： Hyoung Jin Cho ,  Hyungseok Bang ,  Patrick Li Kam Wa

IPC: G01N21/55

CPC classification number: G01N21/553 ,  G01N21/05 ,  G01N2021/0346

Abstract: An integrated optical waveguide type surface plasmon resonance (SPR) sensor having an optical waveguide with a corresponding SPR sensing area, photodetectors, and wavelength tunable laser or any kind of external tunable laser source/coupler formed on a substrate. In an embodiment, the laser is a wavelength tunable laser and optionally, the integrated device may include a power source on the substrate for providing a electric power to the wavelength tunable laser and the photodetectors, or a circuit for signal processing, or a microfluidic structure for routing a target sample to the SPR sensor area. The microfluidic structure optionally includes a mixer or a reaction chamber for mixing and allowing a physical or chemical reaction to occur, respectively. In an embodiment, plural planar integrated optical waveguide type SPR sensors may be fabricated on a substrate to form an array of SPR sensors.

Abstract translation: 一种集成的光波导型表面等离子体共振（SPR）传感器，其具有具有相应的SPR感测区域的光波导，光电探测器和波长可调激光器或形成在衬底上的任何种类的外部可调激光源/耦合器。 在一个实施例中，激光器是波长可调激光器，并且可选地，集成器件可以包括在衬底上的用于向波长可调谐激光器和光电探测器提供电力的电源，或用于信号处理的电路或微流体结构 用于将目标样本路由到SPR传感器区域。 微流体结构任选地包括混合器或用于混合并允许发生物理或化学反应的反应室。 在一个实施例中，可以在基板上制造多个平面集成光波导型SPR传感器，以形成SPR传感器阵列。

公开(公告)号：US20100175821A1

公开(公告)日：2010-07-15

申请号：US12683215

申请日：2010-01-06

Applicant: Hyoung Jin Cho ,  Shekhar Halakatti ,  Anjum Mehta

Inventor： Hyoung Jin Cho ,  Shekhar Halakatti ,  Anjum Mehta

IPC: B29C45/14

CPC classification number: B81B7/0061 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B81B2207/07 ,  G01N33/1806 ,  Y10T137/212 ,  Y10T137/2224

Abstract: A disposable microsensor is designed, fabricated and tested for standard BOD (Biochemical Oxygen Demand) measurements. A transparent Cyclic Olefin Copolymer (COC) substrate is used for sensor fabrication. Standard lithographic procedures in addition to techniques like screen printing and electroplating are used to fabricate the sensor. A microbial strain of Trichosporon Cutaneum is immobilized over one pair of sensor electrodes while the other is used as a reference. Depending on the respiratory activities of the microbial strain in different samples, the BOD values of the samples can be measured in terms of difference between the output signals. The sensor layer is attached to an injection-molded passive microfluidic channel on the top. Advantages of the BOD microsensor include, but are not limited to, fast BOD measurement, disposability because of its low cost, chemically inert polymer substrate, flow-through sample injection scheme and integration of on-chip optics.

Abstract translation: 一次性微量传感器被设计，制造和测试用于标准BOD（生化需氧量）测量。 透明的环烯烃共聚物（COC）基底用于传感器制造。 除了丝网印刷和电镀之类的技术之外，还使用标准平版印刷术来制造传感器。 将Trichosporon Cutaneum的微生物菌株固定在一对传感器电极上，另一个用作参考。 取决于不同样品中微生物菌株的呼吸活动，样品的BOD值可以根据输出信号之间的差异来测量。 传感器层连接到顶部的注射成型的无源微流体通道。 BOD微传感器的优点包括但不限于快速BOD测量，可替换性，因为其低成本，化学惰性聚合物基材，流通样品注入方案和片上光学器件的集成。

公开(公告)号：US07666285B1

公开(公告)日：2010-02-23

申请号：US11106405

申请日：2005-04-14

Applicant: Hyoung Jin Cho ,  Shekhar Halakatti ,  Anjum Mehta

Inventor： Hyoung Jin Cho ,  Shekhar Halakatti ,  Anjum Mehta

IPC: B81C3/00 ,  C12M1/00

CPC classification number: B81B7/0061 ,  B01L3/502707 ,  B01L3/502715 ,  B01L2200/025 ,  B01L2200/027 ,  B01L2200/028 ,  B01L2300/0645 ,  B01L2300/0816 ,  B01L2300/0874 ,  B81B2207/07 ,  G01N33/1806 ,  Y10T137/212 ,  Y10T137/2224

Abstract: A disposable microsensor is designed, fabricated and tested for standard BOD (Biochemical Oxygen Demand) measurements. A transparent Cyclic Olefin Copolymer (COC) substrate is used for sensor fabrication. Standard lithographic procedures in addition to techniques like screen printing and electroplating are used to fabricate the sensor. A microbial strain of Trichosporon Cutaneum is immobilized over one pair of sensor electrodes while the other is used as a reference. Depending on the respiratory activities of the microbial strain in different samples, the BOD values of the samples can be measured in terms of difference between the output signals. The sensor layer is attached to an injection-molded passive microfluidic channel on the top. Advantages of the BOD microsensor include, but are not limited to, fast BOD measurement, disposability because of its low cost, chemically inert polymer substrate, flow-through sample injection scheme and integration of on-chip optics.

Abstract translation: 一次性微量传感器被设计，制造和测试用于标准BOD（生化需氧量）测量。 透明的环烯烃共聚物（COC）基底用于传感器制造。 除了丝网印刷和电镀之类的技术之外，还使用标准平版印刷术来制造传感器。 将Trichosporon Cutaneum的微生物菌株固定在一对传感器电极上，另一个用作参考。 取决于不同样品中微生物菌株的呼吸活动，样品的BOD值可以根据输出信号之间的差异来测量。 传感器层连接到顶部的注射成型的无源微流体通道。 BOD微传感器的优点包括但不限于快速BOD测量，可替换性，因为其低成本，化学惰性聚合物基材，流通样品注入方案和片上光学器件的集成。