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    CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders
    6.
    发明授权
    CXCR4 antagonists including diazine and triazine structures for the treatment of medical disorders 有权
    CXCR4拮抗剂包括用于治疗医学疾病的二嗪和三嗪结构

    公开(公告)号：US08080659B2

    公开(公告)日：2011-12-20

    申请号：US11776476

    申请日：2007-07-11

    申请人： Dennis C. Liotta ,  James P. Snyder ,  Weiqiang Zhan

    发明人： Dennis C. Liotta ,  James P. Snyder ,  Weiqiang Zhan

    IPC分类号： C07D403/12 ,  C07D403/14 ,  A61K31/506 ,  A61P35/00

    CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12

    摘要： The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors or for the treatment of viral infections. The compounds provided interfere with the binding of SDF1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis, or for reducing entry of HIV in to a cell while not reducing the capacity of the stem cells to proliferate. The compounds may be useful for long term treatment regimes.

    摘要翻译： 本发明提供化合物，药物组合物和使用作为趋化因子CXCR4受体的拮抗剂的某些化合物用于治疗由CXCR4受体介导的增殖性病症或用于治疗病毒感染的化合物，药物组合物和方法。 所提供的化合物干扰SDF1与受体的结合。 这些化合物特别可用于通过抑制转移或减少HIV进入细胞而不降低干细胞增殖的能力来治疗或降低过度增殖性疾病的严重性。 这些化合物可用于长期治疗方案。

    CXCR4 Antagonists Including Diazine And Triazine Structures For The Treatment Of Medical Disorders
    8.
    发明申请
    CXCR4 Antagonists Including Diazine And Triazine Structures For The Treatment Of Medical Disorders 有权
    CXCR4拮抗剂包括用于治疗医学疾病的二嗪和三嗪结构

    公开(公告)号：US20090099194A1

    公开(公告)日：2009-04-16

    申请号：US11776476

    申请日：2007-07-11

    申请人： Dennis C. Liotta ,  James P. Snyder ,  Weiqiang Zhan

    发明人： Dennis C. Liotta ,  James P. Snyder ,  Weiqiang Zhan

    IPC分类号： A61K31/496 ,  C07D403/14 ,  A61K31/506 ,  A61P35/04 ,  A61P31/18 ,  C07D403/12

    CPC分类号： C07D239/42 ,  C07D239/47 ,  C07D239/52 ,  C07D401/12 ,  C07D403/06 ,  C07D403/12

    摘要： The invention provides compounds, pharmaceutical compositions and methods of use of certain compounds that are antagonists of the chemokine CXCR4 receptor for the treatment of proliferative conditions mediated by CXCR4 receptors or for the treatment of viral infections. The compounds provided interfere with the binding of SDF 1 to the receptor. These compounds are particularly useful for treating or reducing the severity of hyperproliferative diseases by inhibiting metastasis, or for reducing entry of HIV in to a cell while not reducing the capacity of the stem cells to proliferate. The compounds may be useful for long term treatment regimes.

    摘要翻译： 本发明提供化合物，药物组合物和使用作为趋化因子CXCR4受体的拮抗剂的某些化合物用于治疗由CXCR4受体介导的增殖性病症或用于治疗病毒感染的化合物，药物组合物和方法。 所提供的化合物干扰SDF1与受体的结合。 这些化合物特别可用于通过抑制转移或减少HIV进入细胞而不降低干细胞增殖的能力来治疗或降低过度增殖性疾病的严重性。 这些化合物可用于长期治疗方案。