公开(公告)号：US10239830B2

公开(公告)日：2019-03-26

申请号：US15549743

申请日：2016-02-11

申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Samarjit Patnaik ,  Mercedes Taylor ,  Raul Rolando Calvo ,  Juan Jose Marugan ,  Noel Southall ,  Wei Zheng ,  Marc Ferrer-Alegre ,  Seameen Dehdasthi ,  Patricia Dranchak ,  Fannie Chen ,  Yiannis Ioannou

IPC分类号： C07C311/21 ,  A61K31/4164 ,  A61K31/44 ,  C07D207/335 ,  C07D213/46 ,  C07D233/64 ,  A61K31/165

摘要： Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula 1:

公开(公告)号：US11767498B2

公开(公告)日：2023-09-26

申请号：US16912941

申请日：2020-06-26

申请人： Massachusetts Institute of Technology ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Johanna Bobrow ,  Todd Thorsen ,  David Walsh ,  Christina Zook ,  Min Jae Song ,  Marc Ferrer-Alegre ,  Sam Michael ,  Yen-Ting Tung ,  Molly Elizabeth Boutin

IPC分类号： C12M1/32 ,  B01L3/00 ,  C12M1/12 ,  C12M1/00

CPC分类号： C12M23/12 ,  B01L3/502715 ,  B01L3/502738 ,  C12M23/40 ,  C12M25/14 ,  C12M29/10 ,  B01L2300/0829 ,  B01L2300/0861

摘要： An in vitro tissue plate may include a well plate, a fluidic plate disposed on a bottom surface of the well plate, and a media manifold disposed on a bottom surface of the fluidic plate. The well plate may have at least two wells, including a tissue well and a waste well. The fluid plate may include a fluid channel extending between and fluidly connecting the tissue well to the waste well. The media manifold may include a one or more media outlets fluidly connected to the fluid channel. A tissue layer may be deposited in the tissue well. The tissue layer may include human cells such as neurovascular cells.