公开(公告)号：US10239830B2

公开(公告)日：2019-03-26

申请号：US15549743

申请日：2016-02-11

申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

发明人： Samarjit Patnaik ,  Mercedes Taylor ,  Raul Rolando Calvo ,  Juan Jose Marugan ,  Noel Southall ,  Wei Zheng ,  Marc Ferrer-Alegre ,  Seameen Dehdasthi ,  Patricia Dranchak ,  Fannie Chen ,  Yiannis Ioannou

IPC分类号： C07C311/21 ,  A61K31/4164 ,  A61K31/44 ,  C07D207/335 ,  C07D213/46 ,  C07D233/64 ,  A61K31/165

摘要： Methods and compositions for treating lysosomal storage disorders are disclosed. The methods involve administering a genus of benzenesulfonamides, particularly N-[3-(aminosulfonyl)phenyl]-benzamides and heteroarylamides. A genus of suitable compounds is shown in formula 1:

公开(公告)号：US09464035B2

公开(公告)日：2016-10-11

申请号：US14388494

申请日：2013-03-15

申请人： The United States of America, as Represented by the Secretary, Department of Health and Human Services ,  The University of Kansas

发明人： Juan Jose Marugan ,  Wei Zheng ,  Samarjit Patnaik ,  Noel Southall ,  Ellen Sidransky ,  Ehud Goldin ,  Wendy Westbroek ,  Elma Aflaki ,  Steven Andrew Rogers ,  Frank John Schoenen

IPC分类号： C07C235/64 ,  C07C235/60 ,  C07C237/22

CPC分类号： C07C235/64 ,  C07B2200/07 ,  C07C235/60 ,  C07C237/22

摘要： Compounds of Formula (I) and the pharmaceutically acceptable salts thereof are disclosed. The variables. R1-R13, m, n, o, and p are disclosed herein. The compounds are useful for treating Gaucher disease and inhibiting the onset of Gaucher disease symptoms in a patient having a GBA gene mutation and for treating Parkinson's disease. Pharmaceutical compositions containing compounds of Formula (I) and methods of treatment comprising administering compounds of Formula (I) are also disclosed.