公开(公告)号：US20240425907A1

公开(公告)日：2024-12-26

申请号：US18749217

申请日：2024-06-20

Applicant: ILLUMINA, INC.

Inventor： Niall Gormley ,  Anurag Agrawal ,  Mathieu Lessard-Viger ,  Jonathan Boutell ,  Eli Carrami

IPC: C12Q1/6841 ,  C12Q1/6874

Abstract: The present disclosure is generally directed to strategies for spatial multiomics via target nucleic acid capture and amplification.

公开(公告)号：US20240409981A1

公开(公告)日：2024-12-12

申请号：US18569421

申请日：2022-07-21

Applicant: Illumina, Inc.

Inventor： Anurag Agrawal ,  Jeffrey Brodin ,  Jeffrey Fisher ,  Bo Lu ,  Chenlu Pan

IPC: C12Q1/6818 ,  C12Q1/6827

Abstract: Some examples relate to a method for characterizing polynucleotides in a sample. First polynucleotides coupled to a first substrate may be hybridized to second polynucleotides in a sample. First labeled nucleotides may be added to the first polynucleotides using a sequence of the second polynucleotides. A first signal intensity from the first labeled nucleotides is measured. Second labeled nucleotides are added to the first polynucleotides using the sequence of the second polynucleotides. A second signal intensity from the second labeled nucleotides is measured. The first signal intensity is normalized using the second signal intensity. The normalized first signal intensity characterizes the second polynucleotides in the sample.