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    DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME
    3.
    发明申请
    DISPOSABLE, INTEGRATED MICROFLUIDIC CARTRIDGE AND METHODS OF MAKING AND USING SAME 审中-公开
    一体化的微流控盒及其制造和使用方法

    公开(公告)号：US20170016060A1

    公开(公告)日：2017-01-19

    申请号：US15125124

    申请日：2015-03-11

    Applicant: ILLUMINA, INC.

    Inventor： Poorya Sabounchi ,  Behnam Javanmardi ,  Tarun Khurana ,  Philip Paik ,  Yan-You Lin

    IPC: C12Q1/68 ,  B01L7/00 ,  B01L3/00

    Abstract: The disclosed embodiments concern microfluidic cartridges for detecting biological reactions. In some embodiments, the microfluidic cartridges are configured to perform sequencing operations on a nucleic acid sample. In one aspect, a microfluidic cartridge includes a stack of fluidics layers defining channels and valves for processing the nucleic acid sample to be sequenced, and a solid state CMOS biosensor integrated in the stack. The biosensor has an active area configured to detect signals of biological reactions, wherein substantially all of the active area is available for reagent delivery and illumination during operation. In another aspect, a microfluidic cartridge includes: (a) a flow cell including a reaction site area encompassing one or more reaction sites; (b) fluidics channels for delivering reactants to and/or removing reactants from the reaction site area; (c) a biosensor having an active area configured to detect signals of biological reactions in the reaction site area. The reaction site area is proximal to the active area of the biosensor and the reaction site area spans substantially all of the active area of the biosensor. In some embodiments, the fluidics channels do not substantially overlap with the active area of the biosensor. Methods for manufacturing and operating the microfluidic cartridges are also disclosed.

    Abstract translation: 所公开的实施例涉及用于检测生物反应的微流体盒。 在一些实施方案中，微流控盒被配置为对核酸样品进行测序操作。 在一个方面，微流控筒包括限定用于处理要测序的核酸样品的通道和阀的流体层叠层，以及集成在堆中的固态CMOS生物传感器。 生物传感器具有被配置为检测生物反应的信号的有源区域，其中在操作期间基本上所有的有效区域可用于试剂递送和照明。 在另一方面，微流控盒包括：（a）流动池，包括包含一个或多个反应位点的反应位点区域; （b）用于将反应物输送到和/或从反应部位区域除去反应物的流体通道; （c）生物传感器，其具有被配置为检测反应部位区域中的生物反应信号的有源区域。 反应部位区域靠近生物传感器的有效区域，反应部位区域基本上跨越生物传感器的所有活性区域。 在一些实施例中，流体通道基本上与生物传感器的有效区域重叠。 还公开了用于制造和操作微流控盒的方法。

    Cartridge cover
    4.
    外观设计
    Cartridge cover 有权

    公开(公告)号：USD999425S1

    公开(公告)日：2023-09-19

    申请号：US29714669

    申请日：2019-11-25

    Applicant: Illumina, Inc.

    Designer： Jay Taylor ,  James Osmus ,  Philip Paik ,  Jack Godfrey Wood ,  Max Pollock

    Abstract: FIG. 1 is a perspective view of a cartridge cover showing our new design;
    FIG. 2 is a top plan view of the design of FIG. 1;
    FIG. 3 is a bottom plan view of the design of FIG. 1;
    FIG. 4 is a left side elevational view of the design of FIG. 1;
    FIG. 5 is a right side elevational view of the design of FIG. 1;
    FIG. 6 is a front elevational view of the design of FIG. 1;
    FIG. 7 is a rear elevational view of the design of FIG. 1;
    FIG. 8 is a cross-sectional view taken along line 8-8 in FIG. 2;
    FIG. 9 is a perspective view of an alternate embodiment of the design shown in FIG. 1;
    FIG. 10 is a top plan view of the design of FIG. 9;
    FIG. 11 is a bottom plan view of the design of FIG. 9;
    FIG. 12 is a left side elevational view of the design of FIG. 9;
    FIG. 13 is a right side elevational view of the design of FIG. 9;
    FIG. 14 is a front elevational view of the design of FIG. 9;
    FIG. 15 is a rear elevational view of the design of FIG. 9; and,
    FIG. 16 is a cross-sectional view taken along line 16-16 in FIG. 10.
    The broken lines shown in the drawings illustrate portions of the cartridge cover that form no part of the claimed design.

    Flow cell device
    6.
    外观设计
    Flow cell device 有权

    公开(公告)号：USD1003452S1

    公开(公告)日：2023-10-31

    申请号：US29865479

    申请日：2022-07-27

    Applicant: Illumina, Inc.

    Designer： Jay Taylor ,  Bradley Drews ,  James Osmus ,  Philip Paik ,  Tsukasa Takahashi ,  Brandon Westerberg ,  Jack Godfrey Wood ,  Carlos Dominguez

    Abstract: FIG. 1 is a top plan view of the flow cell device comprising our new design;
    FIG. 2 is a bottom plan of the design of FIG. 1;
    FIG. 3 is a left side elevational view of the design of FIG. 1;
    FIG. 4 is a right side elevational view of the design of FIG. 1;
    FIG. 5 is a front elevational view of the design of FIG. 1;
    FIG. 6 is an enlarged rear elevational view of the design of FIG. 1;
    FIG. 7 is a right-rear perspective view of the design of FIG. 1; and,
    FIG. 8 is a left-rear perspective view of the design of FIG. 1.
    The broken lines shown in the drawings illustrate portions of the flow cell device that form no part of the claimed design. The dash-dot-dot broken lines depict the boundaries of the claim and form no part thereof.

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