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1.发明授权公开(公告)号：US12179190B2
公开(公告)日：2024-12-31
申请号：US18087499
申请日：2022-12-22
Applicant: ILLUMINA, INC.
Inventor： Alex Aravanis , Boyan Boyanov , M. Shane Bowen , Dale Buermann , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Poorya Sabounchi , Hai Quang Tran
Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.
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公开(公告)号：US11852586B2
公开(公告)日：2023-12-26
申请号：US17734953
申请日：2022-05-02
Applicant: Illumina, Inc.
Inventor： Tracy H. Fung , Poorya Sabounchi , Bernard Hirschbein , Joseph Pinto , Tarun Khurana , Randall Smith , Wenyi Feng
CPC classification number: G01N21/6428 , G01N21/6454 , G01N33/53 , G01N2021/6471 , G01N2201/08
Abstract: There is set forth herein a device comprising structure defining a detector surface configured for supporting biological or chemical substances, and a sensor array comprising light sensors and circuitry to transmit data signals using photons detected by the light sensors. The device can include one or more features for reducing fluorescence range noise in a detection band of the sensor array.
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公开(公告)号：US20220275443A1
公开(公告)日：2022-09-01
申请号：US17662124
申请日：2022-05-05
Applicant: Illumina, Inc.
Inventor： Yir-Shyuan Wu , Yan-You Lin , M. Shane Bowen , Cyril Delattre , Fabien Abeille , Tarun Khurana , Arnaud Rival , Poorya Sabounchi , Dajun Yuan , Maria Candelaria Rogert Bacigalupo
IPC: C12Q1/6874 , B05D3/06 , C12Q1/6806 , G03F7/00 , G03F7/20
Abstract: Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.
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公开(公告)号：US20210139979A1
公开(公告)日：2021-05-13
申请号：US17153379
申请日：2021-01-20
Applicant: Illumina, Inc.
Inventor： Yir-Shyuan Wu , Yan-You Lin , M. Shane Bowen , Cyril Delattre , Fabien Abeille , Tarun Khurana , Arnaud Rival , Poorya Sabounchi , Dajun Yuan , Maria Candelaria Rogert Bacigalupo
IPC: C12Q1/6874 , B05D3/06 , C12Q1/6806 , G03F7/00 , G03F7/20
Abstract: Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.
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公开(公告)号：US10900076B2
公开(公告)日：2021-01-26
申请号：US16096669
申请日：2017-05-17
Applicant: Illumina, Inc.
Inventor： Yir-Shyuan Wu , Yan-You Lin , M. Shane Bowen , Cyril Delattre , Fabien Abeille , Tarun Khurana , Arnaud Rival , Poorya Sabounchi , Dajun Yuan , Maria Candelaria Rogert Bacigalupo
IPC: G03F7/20 , C12Q1/6874 , B05D3/06 , C12Q1/6806 , G03F7/00
Abstract: Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.
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Patent Agency Ranking
公开(公告)号：US20160318017A1
公开(公告)日：2016-11-03
申请号：US15205275
申请日：2016-07-08
Applicant: Illumina, Inc.
Inventor： Helmy A. Eltoukhy , Tarun Khurana , Behnam Javanmardi , Poorya Sabounchi , Majid Aghababazadeh
CPC classification number: B01L3/502715 , B01L3/5085 , B01L7/52 , B01L2200/025 , B01L2200/04 , B01L2200/082 , B01L2200/10 , B01L2200/16 , B01L2300/022 , B01L2300/023 , B01L2300/048 , B01L2300/0627 , B01L2300/0636 , B01L2300/0645 , B01L2300/0654 , B01L2300/0819 , B01L2300/0877 , B01L2300/161 , B01L2300/165 , B01L2400/0457 , B01L2400/0487 , B01L2400/0622 , C12Q1/6869 , C12Q1/6874
Abstract: A flow cell including inlet and outlet ports in fluid communication with each other through a flow channel that extends therebetween. The flow channel includes a diffuser region and a field region that is located downstream from the diffuser region. The field region of the flow channel directs fluid along reaction sites where desired reactions occur. The fluid flows through the diffuser region in a first flow direction and through the field region in a second flow direction. The first and second flow directions being substantially perpendicular.
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公开(公告)号：US11747263B2
公开(公告)日：2023-09-05
申请号：US17811750
申请日：2022-07-11
Applicant: Illumina, Inc.
Inventor： Arnaud Rival , Ali Agah , Tracy H. Fung , Dietrich Dehlinger , Poorya Sabounchi , Tarun Khurana , Craig M. Ciesla , M. Shane Bowen
IPC: G01N15/14
CPC classification number: G01N15/1404 , G01N15/1429 , G01N2015/145
Abstract: Flow cells and corresponding methods are provided. The flow cells may include a support frame with top and back sides, and at least one cavity extending from the top side. The flow cells may include at least one light detection device with an active area disposed within the at least one cavity. The flow cells may include a support material disposed within the at least one cavity between the support frame and the periphery of the at least one light detection device coupling them together. The flow cells may include a lid extending over the at least one light detection device and coupled to the support frame about the periphery of the at least one light detection device. The lid and at least a top surface of the at least one light detection device form a flow channel therebetween.
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公开(公告)号：US11702695B2
公开(公告)日：2023-07-18
申请号：US17662124
申请日：2022-05-05
Applicant: Illumina, Inc.
Inventor： Yir-Shyuan Wu , Yan-You Lin , M. Shane Bowen , Cyril Delattre , Fabien Abeille , Tarun Khurana , Arnaud Rival , Poorya Sabounchi , Dajun Yuan , Maria Candelaria Rogert Bacigalupo
IPC: B05D3/06 , G03F7/00 , G03F7/20 , C12Q1/6874 , C12Q1/6806
CPC classification number: C12Q1/6874 , B05D3/06 , C12Q1/6806 , G03F7/0002 , G03F7/20
Abstract: Embodiments provided herewith are directed to self-assembled methods of preparing a patterned surface for sequencing applications including, for example, a patterned flow cell or a patterned surface for digital fluidic devices. The methods utilize photolithography to create a patterned surface with a plurality of microscale or nanoscale contours, separated by hydrophobic interstitial regions, without the need of oxygen plasma treatment during the photolithography process. In addition, the methods avoid the use of any chemical or mechanical polishing steps after the deposition of a gel material to the contours.
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9.发明公开公开(公告)号：US20230145389A1
公开(公告)日：2023-05-11
申请号：US18087499
申请日：2022-12-22
Applicant: ILLUMINA, INC.
Inventor： Alex Aravanis , Boyan Boyanov , M. Shane Bowen , Dale Buermann , Alexander Hsiao , Behnam Javanmardi , Tarun Khurana , Poorya Sabounchi , Hai Quang Tran
CPC classification number: B01L3/502715 , B01L3/502738 , B01L7/525 , F16K99/0013 , F16K99/0015 , F16K99/0028 , B01L2200/04 , B01L2200/10 , B01L2200/16 , B01L2200/025 , B01L2200/027 , B01L2200/0689 , B01L2300/0663 , B01L2300/0816 , B01L2300/0867 , B01L2300/0883 , B01L2300/0887 , B01L2300/1805 , B01L2300/1827 , B01L2400/065 , B01L2400/0633 , B01L2400/0638 , B01L2400/0644 , B01L2400/0655 , F16K2099/0074 , F16K2099/0084
Abstract: Systems and methods for conducting designated reactions utilizing a base instrument and a removable cartridge. The removable cartridge includes a fluidic network that receives and fluidically directs a biological sample to conduct the designated reactions. The removable cartridge also includes a flow-control valve that is operably coupled to the fluidic network and is movable relative to the fluidic network to control flow of the biological sample therethrough. The removable cartridge is configured to separably engage a base instrument. The base instrument includes a valve actuator that engages the flow-control valve of the removable cartridge. A detection assembly held by at least one of the removable cartridge or the base instrument may be used to detect the designated reactions.
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10.发明申请公开(公告)号：US20160199832A1
公开(公告)日：2016-07-14
申请号：US14912394
申请日：2014-08-29
Applicant: ILLUMINA, INC. , ADVANCED LIQUID LOGIC FRANCE SAS
Inventor： Arash Jamshidi , Yan-You Lin , Alex Aravanis , Cyril Delattre , Arnaud Rival , Jennifer Foley , Poorya Sabounchi , Tarun Khurana , Majid Babazadeh , Hamed Amini , Bala Murali Venkatesan , M. Shane Bowen , Steven M. Barnard , Maria Candelaria Rogert Bacigalupo , Dietrich Dehlinger
IPC: B01L3/00
CPC classification number: B01L3/50273 , B01F13/0071 , B01F13/0076 , B01F13/0084 , B01L3/502792 , B01L2200/06 , B01L2300/0636 , B01L2300/0819 , B01L2300/0858 , B01L2300/087 , B01L2300/161 , B01L2300/166 , B01L2400/0427 , B41J2/04 , G01N15/1463 , G01N15/1475 , G01N2015/1006
Abstract: Provided herein is a droplet actuator including (a) first and second substrates separated by a droplet-operations gap, the first and second substrates including respective hydrophobic surfaces that face the droplet-operations gap; (b) a plurality of electrodes coupled to at least one of the first substrate and the second substrate, the electrodes arranged along the droplet-operations gap to control movement of a droplet along the hydrophobic surfaces within the droplet-operations gap; and (c) a hydrophilic or variegated-hydrophilic surface exposed to the droplet-operations gap, the hydrophilic or variegated-hydrophilic surface being positioned to contact the droplet when the droplet is at a select position within the droplet-operations gap.
Abstract translation: 本文提供的液滴致动器包括（a）由液滴操作间隙分离的第一和第二基板，第一和第二基板包括面对液滴操作间隙的各个疏水表面; （b）耦合到第一衬底和第二衬底中的至少一个的多个电极，电极沿着液滴操作间隙排列，以控制液滴沿着液滴操作间隙内的疏水表面的运动; 和（c）暴露于液滴操作间隙的亲水或杂色亲水表面，当液滴在液滴操作间隙内的选择位置时，亲水或杂色亲水表面定位成接触液滴。
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