专利检索 ap:("ILLUMINA CAMBRIDGE LIMITED" OR "ILLUMINA, INC.") AND inv:"Madushani DHARMARWARDANA" 第 1 页

1.

发明公开
COMPOSITIONS AND METHODS FOR REDUCING PHOTO DAMAGE DURING SEQUENCING 审中-公开

公开(公告)号：US20240140939A1

公开(公告)日：2024-05-02

申请号：US18476911

申请日：2023-09-28

申请人： ILLUMINA CAMBRIDGE LIMITED , ILLUMINA, INC.

发明人： Xiaolin WU , Benedict MACKWORTH , Madushani DHARMARWARDANA , Patrick MCCAULEY , Philip STACKHOUSE , Xiaohai LIU , Tao YAN , Krystle REISS

IPC分类号： C07D413/04 , C12Q1/6869

CPC分类号： C07D413/04 , C12Q1/6869

摘要： Embodiments of the present disclosure relate to cyclooctatetraene containing dyes and their uses as fluorescent labels. Also provided are composition containing cyclooctatetraene. The dyes and compositions may be used in various biological applications, such as nucleic acid sequencing.

2.

发明公开
LABELED AVIDIN AND METHODS FOR SEQUENCING 审中-公开

公开(公告)号：US20230304086A1

公开(公告)日：2023-09-28

申请号：US18190330

申请日：2023-03-27

申请人： Illumina Cambridge Limited

发明人： Xiaolin WU , Patrick MCCAULEY , Madushani DHARMARWARDANA

IPC分类号： C12Q1/6869 , C12Q1/6876 , C07K14/36

CPC分类号： C12Q1/6869 , C12Q1/6876 , C07K14/36 , C07K2319/22

摘要： Embodiments of the present disclosure relate to compositions and methods for improving the intensity of the fluorescent signals during nucleic acid sequencing. In particular, at least one biotin-binding site of the labeled streptavidin is blocked to reduce fluorescent signal deflation.