公开(公告)号：US10722460B2

公开(公告)日：2020-07-28

申请号：US15770066

申请日：2016-10-20

Applicant: ILTOO PHARMA

Inventor： Jérémie Mariau ,  Michel Thiry

IPC: A61K38/20 ,  A61K9/08 ,  A61K9/00 ,  A61K47/20 ,  A61K9/19 ,  A61K47/00 ,  A61K47/02 ,  A61J1/05

Abstract: The invention relates to a liquid pharmaceutical composition of Il-2 and its use in the treatment of auto-immune and inflammatory disorders. Methods for preparing said composition and delivery devices filled with said composition are also described.

公开(公告)号：US11883531B2

公开(公告)日：2024-01-30

申请号：US16926881

申请日：2020-07-13

Applicant: ILTOO PHARMA

Inventor： Jérémie Mariau ,  Michel Thiry

IPC: A61K38/20 ,  A61K9/19 ,  A61K9/08 ,  A61K9/00 ,  A61K47/20 ,  A61K47/00 ,  A61K47/02 ,  A61J1/05

CPC classification number: A61K9/08 ,  A61K9/0019 ,  A61K9/19 ,  A61K38/2013 ,  A61K47/00 ,  A61K47/02 ,  A61K47/20 ,  A61J1/05

Abstract: The invention relates to a liquid pharmaceutical composition of Il-2 and its use in the treatment of auto-immune and inflammatory disorders. Methods for preparing said composition and delivery devices filled with said composition are also described.

公开(公告)号：US20210236599A1

公开(公告)日：2021-08-05

申请号：US17268030

申请日：2019-08-13

Applicant: ILTOO PHARMA ,  SORBONNE UNIVERSITE ,  ASSISTANCE PUBLIQUE - HÔPITAUX DE PARIS ,  INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE)

Inventor： David Klatzmann ,  Jérémie Mariau ,  Paul-Gydéon Ritvo ,  Encarnita Mariotti-Ferrandiz ,  Thomas Vazquez ,  Nicolas Billiald

IPC: A61K38/20 ,  A61K38/17 ,  C07K16/24 ,  A61K47/62

Abstract: The present invention relates to a combination of i) interleukin-2 (IL-2) and ii) an interleukin 1 (IL-1) inhibitor, for use in treating an auto-immune and/or inflammatory disorder in a subject. It is also provided a pharmaceutical composition comprising interleukin-2 (IL-2) and an interleukin-1 (IL-1) inhibitor. The invention further provides a conjugate comprising IL-2 conjugated to an IL-1 inhibitor.