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公开(公告)号：US20230094471A1
公开(公告)日：2023-03-30
申请号：US17599347
申请日：2020-03-27
申请人： IMMUNOGEN, INC.
发明人： Ravi V.J. Chari , Michael Louis Miller , Manami Shizuka , Katie Elizabeth Archer , Emily Elizabeth Reid
摘要： The invention relates to benzodiazepine derivatives with antiproliferative activity and more specifically to benzodiazepine compounds of formulae (I), (II), (TI) and (T2). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20210238301A1
公开(公告)日：2021-08-05
申请号：US17143738
申请日：2021-01-07
申请人： IMMUNOGEN, INC.
IPC分类号： C07K16/28 , C07D498/04 , C07D519/00 , A61K47/60 , A61K47/68 , A61P35/00 , C07D487/04 , A61K45/06 , A61K31/5517 , A61K38/07 , C07K5/103 , C07K5/02 , C07K16/46 , C07K19/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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公开(公告)号：US20200048362A1
公开(公告)日：2020-02-13
申请号：US16279113
申请日：2019-02-19
申请人： ImmunoGen, Inc. , Genentech, Inc.
IPC分类号： C07K16/30 , A01K67/027 , C12N15/85 , A61K47/68 , A61K39/395 , C07K16/28 , A61K9/00 , C07K16/32
摘要： The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anti-ErbB receptor antibody-maytansinoid conjugates.
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公开(公告)号：US20170106097A1
公开(公告)日：2017-04-20
申请号：US15170401
申请日：2016-06-01
申请人： IMMUNOGEN, INC. , GENENTECH, INC.
IPC分类号： A61K39/00 , C07K16/32 , A61K31/5365 , A01K67/027 , A61K9/00 , C07K16/30
CPC分类号： C07K16/3015 , A01K67/0271 , A01K67/0275 , A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/052 , A01K2227/105 , A01K2267/0331 , A61K9/0019 , A61K39/39558 , A61K47/6803 , A61K47/6855 , A61K47/6871 , A61K2039/505 , C07K16/2863 , C07K16/32 , C07K2317/24 , C12N15/8509
摘要： The application concerns methods of treatment using anti-ErbB receptor antibody-maytansinoid conjugates, and articles of manufacture suitable for use in such methods. In particular, the invention concerns ErbB receptor-directed cancer therapies, using anti-ErbB receptor antibody-maytansinoid conjugates.
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公开(公告)号：US20170044266A1
公开(公告)日：2017-02-16
申请号：US15221255
申请日：2016-07-27
申请人： ImmunoGen, Inc.
IPC分类号： C07K16/30 , A61K47/48 , A61K31/5517 , C07D519/00
CPC分类号： C07K16/30 , A61K31/5517 , A61K45/06 , A61K47/545 , A61K47/6803 , A61K47/6849 , A61K47/6851 , A61K47/6867 , A61K2039/505 , C07D487/04 , C07D519/00 , C07K2317/24 , C07K2317/92 , C07K2317/94
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
摘要翻译： 本发明涉及具有抗增殖活性的新型苯并二氮杂衍生物，更具体地涉及式（I） - （VII）的新型苯并二氮杂化合物。 本发明还提供了与细胞结合剂连接的苯并二氮杂类化合物的缀合物。 本发明还提供了使用本发明的化合物或缀合物来抑制哺乳动物异常细胞生长或治疗增殖性病症的组合物和方法。
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公开(公告)号：US20160222013A1
公开(公告)日：2016-08-04
申请号：US14990569
申请日：2016-01-07
申请人： ImmunoGen, Inc.
IPC分类号： C07D487/04
CPC分类号： C07K16/2896 , A61K31/5517 , A61K38/07 , A61K45/06 , A61K47/60 , A61K47/6835 , A61K47/6849 , A61K47/6863 , A61P35/00 , C07D487/04 , C07D498/04 , C07D519/00 , C07K5/0202 , C07K5/1008 , C07K16/2803 , C07K16/46 , C07K19/00
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepines of formula (I) and (II), in which the diazepine ring (B) is fused with a heterocyclic ring (CD), wherein the heterocyclic ring is bicyclic or a compound of formula (III), in which the diazepine ring (B) is fused with a heterocyclic ring (C), wherein the heterocyclic ring is monocyclic. The invention provides cytotoxic dimers of these compounds. The invention also provides conjugates of the monomers and the dimers. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention. The invention further relates to methods of using the compounds or conjugates for in vitro, in situ, and in vivo diagnosis or treatment of mammalian cells, or associated pathological conditions.
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公开(公告)号：US20160058882A1
公开(公告)日：2016-03-03
申请号：US14719753
申请日：2015-05-22
申请人： ImmunoGen, Inc.
IPC分类号： A61K47/48 , A61K45/06 , C07D498/18
CPC分类号： C07D498/18 , A61K45/06 , A61K47/60 , A61K47/6803 , A61K47/6849 , C07D498/16
摘要： New ansamitocin derivatives bearing a linking group are disclosed. Also disclosed are methods for the synthesis of these new ansamitocin derivatives and methods for their linkage to cell-binding agents. The ansamitocin derivative-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
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公开(公告)号：US20190269786A1
公开(公告)日：2019-09-05
申请号：US16274665
申请日：2019-02-13
申请人： IMMUNOGEN, INC.
IPC分类号： A61K47/64 , C07K16/28 , C07D519/00 , C07K5/02 , C07K5/113 , C07K5/093 , C07D487/04
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20190263924A1
公开(公告)日：2019-08-29
申请号：US16205609
申请日：2018-11-30
申请人： IMMUNOGEN, INC.
IPC分类号： C07K16/30 , C07D519/00 , A61K45/06 , A61K31/5517 , A61K47/68 , C07D487/04 , A61P35/00 , A61K47/54
摘要： The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VII). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.
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公开(公告)号：US20180043013A1
公开(公告)日：2018-02-15
申请号：US15626575
申请日：2017-06-19
申请人： IMMUNOGEN, INC.
发明人： Ravi V.J. Chari , Wayne C. Widdison
IPC分类号： A61K39/395 , A61K31/5365 , C07D498/16 , A61K39/00
CPC分类号： A61K39/39558 , A61K31/5365 , A61K47/6803 , A61K2039/505 , C07D498/16
摘要： New thiol and disulfide-containing maytansinoids bearing a mono or di-alkyl substitution on the α-carbon atom bearing the sulfur atom are disclosed. Also disclosed are methods for the synthesis of these new maytansinoids and methods for the linkage of these new maytansinoids to cell-binding agents. The maytansinoid-cell-binding agent conjugates are useful as therapeutic agents, which are delivered specifically to target cells and are cytotoxic. These conjugates display vastly improved therapeutic efficacy in animal tumor models compared to the previously described agents.
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