公开(公告)号：US20250011340A1

公开(公告)日：2025-01-09

申请号：US18739709

申请日：2024-06-11

Applicant: IMMUNOGEN, INC.

Inventor： Nicholas C. Yoder ,  Chen Bai ,  Michael Louis Miller

IPC: C07D519/00 ,  A61K39/00 ,  A61K47/68 ,  C07K16/28 ,  C07K16/30

Abstract: The invention relates to novel cell-binding agent-cytotoxic agent conjugates, wherein the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides methods of preparing the conjugates of the present invention. The invention further provides composition and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

公开(公告)号：US11981687B2

公开(公告)日：2024-05-14

申请号：US17841026

申请日：2022-06-15

Applicant: IMMUNOGEN, INC.

Inventor： Baudouin Gérard ,  Richard A. Silva ,  Michael Louis Miller ,  Manami Shizuka

IPC: C07D207/452 ,  C07C205/19 ,  C07D487/04 ,  C07D519/00 ,  C07D519/04

CPC classification number: C07D519/00 ,  C07C205/19 ,  C07D207/452 ,  C07D487/04 ,  C07D519/04

Abstract: The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and their synthetic precursors.

公开(公告)号：US11897961B2

公开(公告)日：2024-02-13

申请号：US17711518

申请日：2022-04-01

Applicant: IMMUNOGEN, INC.

Inventor： Yelena Kovtun ,  Daniel J. Tavares ,  Lingyun Rui ,  Thomas Chittenden

IPC: A61K39/00 ,  C07K16/28 ,  A61K47/68 ,  A61K39/395

CPC classification number: C07K16/2866 ,  A61K47/6801 ,  A61K47/6803 ,  A61K47/6849 ,  A61K47/6883 ,  A61K39/3955 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/76 ,  C07K2317/92

Abstract: The present invention generally relates to antibodies, antigen-binding fragments thereof, polypeptides, and immunoconjugates that bind to CD123 antigen (the α chain of the interleukine 3 receptor, or IL-3Rα). The present invention also relates to methods of using such CD123-binding molecules for diagnosing and treating diseases, such as B-cell malignancies.

公开(公告)号：US20230391733A1

公开(公告)日：2023-12-07

申请号：US18091653

申请日：2022-12-30

Applicant: IMMUNOGEN, INC.

Inventor： Scott A. Hilderbrand ,  Benjamin M. Hutchins

IPC: C07D243/26 ,  C07D487/04 ,  C07K16/28 ,  A61K47/68

CPC classification number: C07D243/26 ,  C07D487/04 ,  C07K16/2866 ,  C07K16/30 ,  A61K47/6803 ,  C07K16/2896 ,  A61K47/6849

Abstract: The invention relates to novel methods of preparing cell-binding agent-cytotoxic agent conjugates, wherein the cytotoxic agent is an imine-containing cytotoxic agent bearing a maleimide group. In some embodiments, the cell-binding agent (CBA) is covalently linked to the cytotoxic agent through an engineered Cys, such as an engineered Cys in the heavy chain CH3 domain, at a position corresponds to the EU/OU numbering position 442 (or C442) on an antibody CBA. The invention also provides conjugates prepared by the methods of the present invention, compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the conjugates of the invention.

公开(公告)号：US11834498B2

公开(公告)日：2023-12-05

申请号：US17838016

申请日：2022-06-10

Applicant: ImmunoGen, Inc.

Inventor： Olga Ab ,  Neeraj Kohli ,  Thomas Chittenden ,  Julianto Setiady

IPC: C07K16/28 ,  A61K31/5365 ,  A61P35/00 ,  A61K47/68

CPC classification number: C07K16/28 ,  A61K31/5365 ,  A61K47/6803 ,  A61P35/00 ,  C07K2317/31 ,  C07K2317/569

Abstract: The present disclosure provides biparatopic antibodies comprising polypeptides that bind to folate receptor alpha (FRα) compositions comprising such biparatopic antibodies. In a specific aspect, the biparatopic antibodies bind to FRα and modulate FRα activity. The present disclosure also provides methods for treating disorders, such as cancer, by administering a biparatopic antibody that specifically binds to FRα and modulates FRα activity.

公开(公告)号：US11744900B2

公开(公告)日：2023-09-05

申请号：US17371151

申请日：2021-07-09

Applicant: ImmunoGen, Inc.

Inventor： Xinfang Li ,  Jared M. Worful

IPC: A61K39/00 ,  A61K47/68 ,  C07K1/113 ,  C07K16/28 ,  C07K16/32

CPC classification number: A61K47/6803 ,  A61K47/6809 ,  A61K47/6819 ,  A61K47/6849 ,  A61K47/6867 ,  C07K1/113 ,  C07K16/2896 ,  C07K16/32

Abstract: The invention provides a one-step process for preparing a cell-binding agent cytotoxic agent conjugate comprising contacting a cell-binding agent with a cytotoxic agent to form a first mixture comprising the cell-binding agent and the cytotoxic agent and contacting the first mixture comprising the cell-binding agent and the cytotoxic agent with a bifunctional crosslinking reagent, which provides a linker, in a solution having a pH of about 4 to about 9 to provide a second mixture comprising the cell-binding agent cytotoxic agent conjugate, wherein the cell-binding agent is chemically coupled through the linker to the cytotoxic agent, free cytotoxic agent, and reaction by-products. The second mixture is then optionally subjected to purification to provide a purified cell-binding agent cytotoxic agent conjugate.

公开(公告)号：US20230233697A1

公开(公告)日：2023-07-27

申请号：US17973209

申请日：2022-10-25

Applicant: IMMUNOGEN, INC.

Inventor： Ravi V.J. Chari ,  Michael Louis Miller ,  Manami Shizuka

IPC: A61K47/64 ,  C07K5/02 ,  C07K16/28 ,  C07K5/113 ,  C07D519/00 ,  C07D487/04 ,  C07K5/093 ,  A61K39/00

CPC classification number: A61K47/64 ,  C07K5/0202 ,  C07K16/2866 ,  C07K16/2863 ,  C07K5/1021 ,  C07D519/00 ,  C07K16/28 ,  C07D487/04 ,  C07K5/0819 ,  C07K2317/24 ,  A61K2039/505 ,  C07K2317/92

Abstract: The invention relates to novel benzodiazepine derivatives with antiproliferative activity and more specifically to novel benzodiazepine compounds of formula (I)-(VI). The invention also provides conjugates of the benzodiazepine compounds linked to a cell-binding agent. The invention further provides compositions and methods useful for inhibiting abnormal cell growth or treating a proliferative disorder in a mammal using the compounds or conjugates of the invention.

公开(公告)号：US11701428B2

公开(公告)日：2023-07-18

申请号：US16862358

申请日：2020-04-29

Applicant: ImmunoGen, Inc.

Inventor： Sharlene Adams ,  Callum M. Sloss ,  Patrick Zweidler-McKay

IPC: A61K47/68 ,  A61P35/00 ,  C07K16/28

CPC classification number: A61K47/6849 ,  A61P35/00 ,  C07K16/2866

Abstract: Therapeutic combinations of immunoconjugates that bind to CD123 (e.g., IMGN632) with BCL-2 inhibitors (e.g., venetoclax), and/or a hypomethylating agent (e.g., azacitidine or decitabine) are provided. Methods of administering the combinations to treat hematological malignancies with clinical efficacy and/or decreased toxicity are also provided. Methods of treating hematological malignances present as minimal residual disease using immunoconjugates that bind to CD123 (e.g., IMGN632) are also provided.

公开(公告)号：US20230158168A1

公开(公告)日：2023-05-25

申请号：US17940297

申请日：2022-09-08

Applicant: Immunogen, Inc.

Inventor： Yong DAI ,  Yong WANG ,  Shengjin JIN ,  Deborah H. MESHULAM ,  Godfrey W. AMPHLETT

IPC: A61K47/68 ,  C07K16/28

CPC classification number: A61K47/6803 ,  A61K47/6867 ,  C07K16/2896 ,  A61K47/6809 ,  C07K16/2839 ,  C07K16/2884 ,  C07K2317/24 ,  C07K2317/40

Abstract: The invention provides a process for preparing a cell-binding agent chemically coupled to a drug. The process comprises covalently attaching a linker to a cell-binding agent, a purification step, conjugating a drug to the cell-binding agent and a subsequent purification step.

公开(公告)号：US11198736B2

公开(公告)日：2021-12-14

申请号：US16707940

申请日：2019-12-09

Applicant: ImmunoGen, Inc.

Inventor： Olga Ab ,  Daniel Tavares ,  Juliantro Setiady ,  Sharron Ladd ,  Christina N. Carrigan ,  Lingyun Rui

IPC: C07K16/30 ,  C07K16/28 ,  A61K47/68 ,  A61K39/00 ,  G01N33/574 ,  G01N33/547

Abstract: The invention generally relates to antibodies that bind to human folate receptor and diagnostic assays for folate receptor 1-based therapies. Methods of using the antibodies to monitor therapy are further provided.