公开(公告)号：US20230077072A1

公开(公告)日：2023-03-09

申请号：US17758701

申请日：2021-01-14

申请人： Indena S.P.A.

发明人： Antonella Riva ,  Massimo Ronchi ,  Giovanna Petrangolini ,  Paolo Morazzoni

IPC分类号： A61K36/87 ,  A61K31/353 ,  A61P25/22 ,  A61K9/20 ,  A61K9/28

摘要： Disclosed are compositions comprising grape seed extracts, in particular extracts with a proanthocyanidin content exceeding 95% by weight and a catechin and epicatechin content ≥5% and ≤15% by weight, which are useful to prevent or reduce the perception of stress symptoms, in particular the perception of stress among the male population.

公开(公告)号：US09556099B2

公开(公告)日：2017-01-31

申请号：US14892153

申请日：2014-06-17

申请人： INDENA S.P.A.

发明人： Paolo Morazzoni ,  Antonella Riva ,  Gabriele Fontana

IPC分类号： C07C49/757 ,  C07C45/67

CPC分类号： C07C49/757 ,  C07C45/673 ,  C07C2602/46

摘要： Disclosed is a compound having the formula a) or b); a: R=CH3; b: R=CH2CH3, and its use in the prevention and/or treatment of Alzheimer's disease.

摘要翻译： 公开了具有式a）或b）的化合物; a：R = CH3; b：R = CH2CH3，以及其在预防和/或治疗阿尔茨海默病中的用途。

公开(公告)号：US20210244782A1

公开(公告)日：2021-08-12

申请号：US17262148

申请日：2019-07-23

申请人： Indena S.P.A.

发明人： Sabrina Arpini ,  Giacomo Mombelli ,  Paolo Morazzoni ,  Federico Peterlongo ,  Antonella Riva ,  Massimo Ronchi

IPC分类号： A61K36/45 ,  A61K31/685 ,  A61P31/00 ,  A61P13/02

摘要： The present invention relates to compositions comprising an American cranberry extract combined with phospholipids, and the use thereof in the prevention and treatment of urinary tract infections. The invention also relates to processes for the preparation of said compositions, and formulations for oral administration comprising said compositions.

公开(公告)号：US11331298B2

公开(公告)日：2022-05-17

申请号：US16631285

申请日：2018-07-16

申请人： INDENA S.P.A.

发明人： Massimo Ronchi ,  Elisabetta Frattini ,  Antonella Riva

IPC分类号： A61K31/352 ,  A61K9/10 ,  A61K9/14 ,  A61K9/16 ,  A61K47/24

摘要： Disclosed are powder solid dispersions including quercetin, phospholipids and a very to freely water soluble carrier. Also disclosed are a process for the preparation of the powder solid dispersions and pharmaceutical, nutraceutical and cosmetic compositions including the solid dispersions.

公开(公告)号：US20160115111A1

公开(公告)日：2016-04-28

申请号：US14892153

申请日：2014-06-17

申请人： INDENA S.P.A.

发明人： Paolo Morazzoni ,  Antonella Riva ,  Gabriele Fontana

IPC分类号： C07C49/757

CPC分类号： C07C49/757 ,  C07C45/673 ,  C07C2602/46

摘要： Disclosed is a compound having the formula a) or b); a: R=CH3; b: R=CH2CH3, and its use in the prevention and/or treatment of Alzheimer's disease.

摘要翻译： 公开了具有式a）或b）的化合物; a：R = CH3; b：R = CH2CH3，以及其在预防和/或治疗阿尔茨海默病中的用途。

公开(公告)号：US20160038577A1

公开(公告)日：2016-02-11

申请号：US14819540

申请日：2015-08-06

申请人： Indena S.p.A. Con Socio Unico

发明人： Paolo Morazzoni ,  Antonella Riva ,  Giovanna Petrangolini ,  Ruggero Cadossi ,  Mattia Ronchetti

IPC分类号： A61K39/00 ,  A61K41/00 ,  C12N9/12

CPC分类号： A61K39/0011 ,  A61K41/0047 ,  A61K2039/53 ,  A61K2039/54 ,  C12N9/12 ,  C12Y207/10001

摘要： The present invention relates to a plasmid comprising a sequence encoding for a fragment of p185neu chosen in the group consisting of SEQ ID 1, 2, 3, 4, 5, 6 carried by applying a pulsating voltage having an intensity comprised in the range from 100 to 200 V, through a needle electrode for use in the preventive or therapeutic treatment of subjects at risk of developing p185neu-positive tumors, or of patients with p185neu-positive primary tumors, metastasis or relapses.

摘要翻译： 本发明涉及包含编码p185neu片段的序列的质粒，所述序列选自SEQ ID No.1,2,3,4,5,6，其通过施加具有在100范围内的强度的脉动电压 至200V，通过针状电极用于预防或治疗患有发生p185neu阳性肿瘤风险的受试者，或患有p185neu阳性原发性肿瘤的患者，转移或复发。

公开(公告)号：US20230398134A1

公开(公告)日：2023-12-14

申请号：US18252067

申请日：2021-11-12

申请人： INDENA S.P.A.

发明人： Pietro Allegrini ,  Massimo Ronchi ,  Antonella Riva

IPC分类号： A61K31/00 ,  A61K9/16 ,  A61K9/10

CPC分类号： A61K31/658 ,  A61K9/1652 ,  A61K9/10

摘要： The present invention relates to a composition comprising cannabidiol and at least two excipients, wherein at least one excipient is a lipid excipient and wherein at least one excipient is a hydrophilic excipient, and wherein the lipid excipient is present in an amount equal to or lower than 20% of the total weight of the composition; the invention also relates to the preparation process of the composition and to pharmaceutical or nutraceutical formulations containing it.

公开(公告)号：US11786513B2

公开(公告)日：2023-10-17

申请号：US16966298

申请日：2019-01-22

申请人： INDENA S.P.A.

发明人： Fabrizio Corti ,  Massimo Ronchi ,  Antonella Riva

IPC分类号： A61K31/4375 ,  A61K36/48 ,  A61K36/752 ,  A61K36/87 ,  A61K47/14

CPC分类号： A61K31/4375 ,  A61K36/48 ,  A61K36/752 ,  A61K36/87 ,  A61K47/14

摘要： Disclosed are compositions including berberine combined with pea proteins and one or more surfactants. Also disclosed are processes for the preparation of the compositions, and the formulations and uses thereof.