公开(公告)号：US20150290206A1

公开(公告)日：2015-10-15

申请号：US14647387

申请日：2013-12-03

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Vincent Gattone ,  Bonnie Blazer-Yost

IPC: A61K31/5377 ,  A61M27/00 ,  A61K31/18

CPC classification number: A61K31/5377 ,  A61K31/00 ,  A61K31/165 ,  A61K31/18 ,  A61K31/202 ,  A61K31/225 ,  A61K31/28 ,  A61K31/405 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/55 ,  A61M27/006

Abstract: The present invention provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, eg. cancer, benign tumor, etc.). Related materials and methods are also provided herein.

Abstract translation: 本发明提供TRPV4拮抗剂用于治疗或预防脑积水症状，也称为脑积水，包括由于任何结构缺陷导致的脑积水，任何代谢缺陷，任何损伤（对头部的直接力，对头部的间接力） ，冲击波，压力变化等），任何侮辱（微生物，化学，毒素，过敏反应或其他炎症过程或其他病理学，例如癌症，良性肿瘤等）。 本文还提供了相关材料和方法。

公开(公告)号：US10335414B2

公开(公告)日：2019-07-02

申请号：US14647387

申请日：2013-12-03

Applicant: Indiana University Research and Technology Corporation

Inventor： Vincent Gattone ,  Bonnie Blazer-Yost

IPC: A61K31/00 ,  A61K31/18 ,  A61M27/00 ,  A61K31/165 ,  A61K31/4439 ,  A61K31/28 ,  A61K31/55 ,  A61K31/202 ,  A61K31/225 ,  A61K31/405 ,  A61K31/495 ,  A61K31/496 ,  A61K31/5377 ,  A61K31/4995

Abstract: The present invention provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, eg. cancer, benign tumor, etc.). Related materials and methods are also provided herein.

公开(公告)号：US11318140B2

公开(公告)日：2022-05-03

申请号：US16412205

申请日：2019-05-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Vincent Gattone ,  Bonnie Blazer-Yost

IPC: A61K31/5377 ,  A61K31/00 ,  A61K31/405 ,  A61K31/165 ,  A61K31/18 ,  A61K31/202 ,  A61K31/225 ,  A61K31/28 ,  A61K31/4439 ,  A61K31/495 ,  A61K31/496 ,  A61K31/4995 ,  A61K31/55 ,  A61M27/00

Abstract: The present disclosure provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, e.g. cancer, benign tumor, etc.). Related materials and methods are also provided herein.

公开(公告)号：US20190262350A1

公开(公告)日：2019-08-29

申请号：US16412205

申请日：2019-05-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Vincent Gattone ,  Bonnie Blazer-Yost

IPC: A61K31/5377 ,  A61K31/405 ,  A61K31/00 ,  A61M27/00 ,  A61K31/4995 ,  A61K31/496 ,  A61K31/495 ,  A61K31/55 ,  A61K31/28 ,  A61K31/225 ,  A61K31/202 ,  A61K31/18 ,  A61K31/165 ,  A61K31/4439

Abstract: The present disclosure provides uses of TRPV4 antagonists in the treatment or prevention of hydrocephalus symptoms, also known as hydrocephaly, including hydrocephalus as a result of any structural defect, any metabolic defect, any injury (direct force to the head, indirect force to the head, shock waves, pressure changes, etc.), any insult (microbial, chemical, toxins, allergic reactions or other inflammatory process, or other pathology, e.g. cancer, benign tumor, etc.). Related materials and methods are also provided herein.

公开(公告)号：US09579335B2

公开(公告)日：2017-02-28

申请号：US14853216

申请日：2015-09-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Bonnie Blazer-Yost

IPC: A01N57/00 ,  A61K31/675 ,  A61K31/7024 ,  A61K45/06

CPC classification number: A61K31/7024 ,  A61K31/675 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention described herein pertains to the treatment of cystic diseases. More particularly, the invention described herein relates to methods for treating cystic disease using one or more lysophosphatidic acid antagonists, TMEM16a inhibitors, and/or peroxisome proliferator-activated receptor modulators.

Abstract translation: 本文描述的本发明涉及囊性疾病的治疗。 更具体地，本文描述的本发明涉及使用一种或多种溶血磷脂酸拮抗剂，TMEM16a抑制剂和/或过氧化物酶体增殖物激活的受体调节剂治疗囊性疾病的方法。

公开(公告)号：US20160000814A1

公开(公告)日：2016-01-07

申请号：US14853216

申请日：2015-09-14

Applicant: Indiana University Research and Technology Corporation

Inventor： Bonnie Blazer-Yost

IPC: A61K31/7024 ,  A61K45/06 ,  A61K31/675

CPC classification number: A61K31/7024 ,  A61K31/675 ,  A61K45/06 ,  A61K2300/00

Abstract: The invention described herein pertains to the treatment of cystic diseases. More particularly, the invention described herein relates to methods for treating cystic disease using one or more lysophosphatidic acid antagonists, TMEM16a inhibitors, and/or peroxisome proliferator-activated receptor modulators.

Abstract translation: 本文描述的本发明涉及囊性疾病的治疗。 更具体地，本文描述的本发明涉及使用一种或多种溶血磷脂酸拮抗剂，TMEM16a抑制剂和/或过氧化物酶体增殖物激活的受体调节剂治疗囊性疾病的方法。