公开(公告)号：US20140148381A1

公开(公告)日：2014-05-29

申请号：US14232377

申请日：2012-07-13

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Adam Zlotnick ,  Daniel Loeb

IPC: A61K38/16

CPC classification number: A61K38/162 ,  A01K67/027 ,  A01K2207/05 ,  A01K2267/0337 ,  A61K38/00 ,  C07K14/005 ,  C12N2730/10122 ,  C12N2730/10133 ,  C12N2740/16222 ,  C12N2799/025 ,  G01N33/56983

Abstract: This disclosure provides a novel strategy to cope with chronic virus infection by introducing a dominant negative viral structural protein to disturb effective virion production. The dominant negative structural protein mimics antiviral drugs through structural and biochemical interactions during virus assembly. An effective gene therapy model for chronic viral infected diseases is proposed in this disclosure, as represented by HBV Cpdominant 1 to clear viral infection.

Abstract translation: 本公开提供了通过引入显性阴性病毒结构蛋白来干扰有效的病毒粒子产生来应对慢性病毒感染的新策略。 显性阴性结构蛋白在病毒组装过程中通过结构和生化相互作用模拟抗病毒药物。 在本公开中提出了用于慢性病毒感染疾病的有效的基因治疗模型，由HBV Cpdominant 1表示以清除病毒感染。