公开(公告)号：US20170281788A1

公开(公告)日：2017-10-05

申请号：US15513748

申请日：2015-09-23

Applicant: INDIANA UNIVERSITY RESEARCH AND TECHNOLOGY CORPORATION

Inventor： Richard D. DIMARCHI ,  John P. MAYER ,  David L. SMILEY ,  Fa LIU

IPC: A61K47/48 ,  A61K38/28 ,  C07K19/00 ,  A61K38/22 ,  C07K14/575

CPC classification number: A61K38/22 ,  A61K9/0019 ,  A61K9/0024 ,  A61K38/00 ,  A61K38/28 ,  A61K47/02 ,  A61K47/545 ,  A61K47/64 ,  C07K2/00 ,  C07K14/575 ,  C07K14/605 ,  C07K14/62

Abstract: Disclosed herein are insulin agonist peptides conjugated to incretins wherein the incretin-insulin conjugate has agonist activity at the insulin receptor and the corresponding incretin receptor, and stimulates weight loss in an individual administered the compound.