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    Antibacterial and fungicidal peptide in which lysine and tryptophan residues are repeated, and use thereof
    3.
    发明授权
    Antibacterial and fungicidal peptide in which lysine and tryptophan residues are repeated, and use thereof 有权

    公开(公告)号：US10301354B2

    公开(公告)日：2019-05-28

    申请号：US15833875

    申请日：2017-12-06

    Applicant: Industry-Academic Cooperation Foundation, Chosun University

    Inventor： Yoon Kyung Park

    IPC: C07K5/103 ,  C07K7/06 ,  C07K5/11 ,  C07K7/08 ,  A61K38/00

    Abstract: The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the antibacterial and fungicidal peptide of the present invention, in which lysine and tryptophan dipeptide is repeated four times, shows excellent antibacterial activities with respect to gram-positive bacteria, gram-negative bacteria and antibiotic-resistant strains by affecting the inner membrane of harmful microorganisms, has remarkable fungicidal activities with respect to pathogenic fungi and antibiotic-resistant fungi, and shows little cytotoxicity, and thus can be useful for a pharmaceutical composition, a cosmetic composition, agricultural chemicals, a food preservative, a cosmetic preservative, and a pharmaceutical preservative.

    Antibiotic peptide derived from helicobacter pylori ribosomal protein L1 and uses thereof
    4.
    发明授权
    Antibiotic peptide derived from helicobacter pylori ribosomal protein L1 and uses thereof 有权
    衍生自幽门螺杆菌核糖体蛋白L1的抗生素肽及其用途

    公开(公告)号：US09463214B2

    公开(公告)日：2016-10-11

    申请号：US14789041

    申请日：2015-07-01

    Applicant: INDUSTRY-ACADEMIC COOPERATION FOUNDATION, CHOSUN UNIVERSITY

    Inventor： Yoon Kyung Park ,  Jong Kuk Lee

    IPC: A61K38/10 ,  C07K7/08 ,  C07K14/205

    CPC classification number: A61K38/10 ,  C07K7/08 ,  C07K14/205 ,  Y02A50/473

    Abstract: The present invention relates to a peptide derived from the Helicobacter pylori ribosomal protein L1, and the use of this peptide an antibiotic. More specifically, the peptide is derived by making site-specific substitution mutations in a peptide consisting of amino acids 2-20 of the Helicobacter pylori ribosomal protein L1. The resulting peptide has both antibacterial activity and anti-inflammatory activity, but no cytotoxicity.

    Abstract translation: 本发明涉及一种衍生自幽门螺杆菌核糖体蛋白L1的肽以及该肽作为抗生素的用途。 更具体地，通过在由幽门螺杆菌核糖体蛋白L1的氨基酸2-20组成的肽中进行位点特异性取代突变而获得肽。 所得肽具有抗菌活性和抗炎活性，但无细胞毒性。

    NOVEL ANTIBACTERIAL AND FUNGICIDAL PEPTIDE IN WHICH LYSINE AND TRYPTOPHAN RESIDUES ARE REPEATED, AND USE THEREOF
    5.
    发明申请
    NOVEL ANTIBACTERIAL AND FUNGICIDAL PEPTIDE IN WHICH LYSINE AND TRYPTOPHAN RESIDUES ARE REPEATED, AND USE THEREOF 审中-公开
    新鲜的抗菌和杀真菌肽，其中LYSINE和TRYPTOPHAN残留物被重复使用，并被使用

    公开(公告)号：US20140309162A1

    公开(公告)日：2014-10-16

    申请号：US14318106

    申请日：2014-06-27

    Applicant: Industry-Academic Cooperation Foundation, Chosun University

    Inventor： Yoon Kyung Park

    IPC: C07K7/06 ,  C07K5/103

    CPC classification number: C07K5/101 ,  A61K38/00 ,  C07K5/1019 ,  C07K7/06 ,  C07K7/08 ,  Y02A50/473 ,  Y02A50/481

    Abstract: The present invention relates to an antibacterial and fungicidal peptide in which a lysine and tryptophan dipeptide is repeated. More specifically, the antibacterial and fungicidal peptide of the present invention, in which lysine and tryptophan dipeptide is repeated four times, shows excellent antibacterial activities with respect to gram-positive bacteria, gram-negative bacteria and antibiotic-resistant strains by affecting the inner membrane of harmful microorganisms, has remarkable fungicidal activities with respect to pathogenic fungi and antibiotic-resistant fungi, and shows little cytotoxicity, and thus can be useful for a pharmaceutical composition, a cosmetic composition, agricultural chemicals, a food preservative, a cosmetic preservative, and a pharmaceutical preservative.

    Abstract translation: 本发明涉及其中重复赖氨酸和色氨酸二肽的抗细菌和杀真菌肽。 更具体地，本发明的其中赖氨酸和色氨酸二肽重复四次的抗细菌和杀真菌肽对于革兰氏阳性细菌，革兰氏阴性细菌和抗生素抗性菌株通过影响内膜显示出优异的抗菌活性 的有害微生物，对于致病真菌和抗生素抗性真菌具有显着的杀真菌活性，并且显示出很少的细胞毒性，因此可用于药物组合物，化妆品组合物，农药，食品防腐剂，化妆品防腐剂和 药用防腐剂。

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