公开(公告)号：US20210077065A1

公开(公告)日：2021-03-18

申请号：US16970810

申请日：2019-02-18

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE - CNRS ,  SORBONNE UNIVERSITE ,  UNIVERSITÉ DE PARIS

发明人： Mathieu PERNOT ,  Clément PAPADACCI ,  Mickael TANTER

IPC分类号： A61B8/08 ,  A61B8/06 ,  A61B8/14 ,  A61B8/00 ,  G06T13/20 ,  G06T7/00 ,  G06T7/70 ,  G16H30/40 ,  G16H30/20

摘要： The invention relates to the field of ultrasound imaging of the heart. 4D ultrafast ultrasound imaging of the heart is performed and may be used to compute major cardiac echo-graphic Flow and Tissue Doppler index indexes such as E/E′, E/Apex A, E′/A′ with a single acquisition in a very quick time (e.g. with-in a heart beat) and in a reproducible way, independently of the experience of the operator.

公开(公告)号：US20180326370A1

公开(公告)日：2018-11-15

申请号：US15774253

申请日：2016-11-08

申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE-CNRS ,  INSERM (Institut National de la Santé et de la Recherche Médicale) ,  Ecole Supérieure de Physique et de Chimie Industrielles de la Ville de Paris

发明人： Olivier COUTURE ,  Mickael TANTER ,  Claudia ERRICO

IPC分类号： B01F3/08 ,  B01F13/00 ,  B01F5/04

CPC分类号： B01F3/0807 ,  B01F5/0475 ,  B01F13/0071 ,  B01F2003/0834

摘要： A method for manufacturing an emulsion comprises drops in an external solution, the drops containing a fluid. The fluid is moved along a first main channel, a portion of the fluid moving in the first main channel is withdrawn via a plurality of microchannels positioned in parallel between the first main channel and a second main channel filled with external solution, the drops are formed by hydrodynamic focusing when the fluid passes from each microchannel into the second main channel.

公开(公告)号：US20240180524A1

公开(公告)日：2024-06-06

申请号：US18553591

申请日：2022-04-01

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE ,  ECOLE SUPÉRIEURE DE PHYSIQUE ET DE CHIMIE INDUSTRIELLES DE LA VILLE DE PARIS

发明人： Clément PAPADACCI ,  Mickael TANTER ,  Hugues FARVE ,  Mathieu PERNOT

IPC分类号： A61B8/08 ,  A61B8/00 ,  B06B1/06 ,  G01S7/52 ,  G01S15/89

CPC分类号： A61B8/483 ,  A61B8/4488 ,  A61B8/481 ,  A61B8/5269 ,  A61B8/54 ,  B06B1/0629 ,  B06B1/0651 ,  G01S7/52039 ,  G01S7/52046 ,  G01S7/52079 ,  G01S15/8925 ,  G01S15/8981 ,  G01S15/8993 ,  G01S15/8997 ,  B06B2201/76

摘要： While 3D ultrasound imaging is becoming a powerful tool in medical field. the main drawback is the difficulty to image large 3D volume. mainly related to the dimensions of the 2D array of transducers. In order to not lose in spatial resolution, it is necessary to use an array of transducers. wherein the size of the transducers does not exceed the wavelength of the ultrasound wave. Such requirement leads to dimensions of array for imaging large 3D volume which are not reachable or at too high cost with the current technology. The present disclosure overcomes the above technology limitation by using greater transducers, and where each transducer has a reception surface with a curved shape or is fitted with an acoustic lens. Such configuration of transducers leads to 2D array of transducers suitable for imaging large 3D volume, as a brain or a heart. with high resolution and high sensitivity.

公开(公告)号：US20230225698A1

公开(公告)日：2023-07-20

申请号：US17996094

申请日：2021-04-13

申请人： INSERM (INSTITUT NATIONAL DE LA SANTÉ ET DE LA RECHERCHE MÉDICALE) ,  Centre National de la Recherche Scientifique (CNRS) ,  Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris

发明人： Mathieu PERNOT ,  Mickael TANTER ,  Clément PAPADACCI ,  Oscar DEMEULENAERE

IPC分类号： A61B8/06 ,  A61B8/08

CPC分类号： A61B8/06 ,  A61B8/488 ,  A61B8/5223 ,  A61B8/0883

摘要： The present invention relates to the field of ultrasounds and imagining of the coronary blood flow of the heart. Patients with coronary microvascular dysfunction (CMD) have poor prognostic with significantly higher rates of cardiovascular events, including hospitalization for heart failure, sudden cardiac death, and myocardial infarction (MI). Despite the urgent clinical need, there are no non-ionizing and non-invasive techniques available in clinic to directly visualize the coronary microvasculature and assess the local coronary microvascular system. Flow imaging remains a difficult task to perform in the heart because of the fast movements of this organ. In order to overcome the limitations of actual imaging methods for the coronary blood flow, the inventors proposed an ultrasound ultrafast imaging method that automatically detect the time periods in which the myocardium velocity is low and estimate the coronary flow velocity and the tissue velocity from the same data acquisition.

公开(公告)号：US20200093465A1

公开(公告)日：2020-03-26

申请号：US16695974

申请日：2019-11-26

申请人： SUPER SONIC IMAGINE ,  CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)

发明人： Jeremy BERCOFF ,  David SAVERY ,  Mickael TANTER ,  Jean-Luc GENNISON ,  Mathias FINK ,  Claude COHEN-BACRIE

IPC分类号： A61B8/08 ,  G01N29/36 ,  G01N29/34 ,  G01N29/44 ,  A61B8/00 ,  G06T7/00 ,  A61B5/00 ,  G01S7/52 ,  G01S15/89

摘要： The invention relates to a method for measuring a mean visco-elasticity value for a soft material. Said method using a single probe carrying at least one transducer comprises the steps of:a) inducing, in a constraint zone, at least one burst of mechanical vibrations in order to generate internal shear waves in the tissue propagating from said constraint zone into the tissue,b1) measuring, with said transducer, the transient tissue displacements in at least one first measurement zone in the tissue, said first measurement zone being located away from said constraint zone,c) estimating a mean visco-elasticity of the region of the tissue situated between the constraint zone and the first measurement zone from said measured transient tissue displacements of the tissue in the first measurement zone.