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1.METHOD AND PHARMACEUTICAL COMPOSITION FOR USE IN THE TREATMENT AND DIAGNOTIC OF ANEMIA OF INFLAMMATION 审中-公开
标题翻译: 用于治疗和诊断炎症反应的方法和药物组合物公开(公告)号:US20150125471A1
公开(公告)日:2015-05-07
申请号:US14397742
申请日:2013-05-03
申请人: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE) , UNIVERSITE PAUL SABATIER TOULOSE III , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)
发明人: Marie-Paule Roth , Hélène Coppin
CPC分类号: C07K16/2863 , C07K14/71 , C07K16/22 , C07K16/26 , C07K2317/76 , C12Q1/6883 , C12Q2600/158 , G01N33/74 , G01N2333/475 , G01N2800/22 , G01N2800/7095
摘要: The present invention relates to a compound which inhibits the binding of activin B to ALK3 receptor or a compound which is an inhibitor of activin B expression or ALK3 receptor expression for use in the treatment of anemia of inflammation. The invention also relates to a method for diagnosis anemia of inflammation in a patient comprising: determining the expression level of Activin B in a sample obtained from said patient; and comparing said expression level to a threshold value.
摘要翻译: 本发明涉及抑制激活素B与ALK3受体结合的化合物或作为激活素B表达或ALK3受体表达抑制剂的化合物,用于治疗炎症性贫血。 本发明还涉及一种用于诊断患者炎症的贫血的方法,包括:测定从所述患者获得的样品中的活化素B的表达水平; 并将所述表达水平与阈值进行比较。
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公开(公告)号:US20140030272A1
公开(公告)日:2014-01-30
申请号:US14045531
申请日:2013-10-03
发明人: Marie-Paule Roth
IPC分类号: G01N33/68 , C12Q1/68 , C07K16/22 , C07K14/51 , C12N15/113
CPC分类号: G01N33/74 , A61K31/7088 , A61K38/00 , A61K38/1875 , C07K14/51 , C07K16/22 , C12N15/1136 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6887 , G01N33/6893 , G01N2333/51 , G01N2800/04 , G01N2800/22
摘要: The present invention relates to methods for diagnosing and treating iron overload and iron deficiency.
摘要翻译: 本发明涉及铁超载和铁缺乏症的诊断和治疗方法。
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公开(公告)号:US20170052202A1
公开(公告)日:2017-02-23
申请号:US15344197
申请日:2016-11-04
发明人: Marie-Paule Roth
CPC分类号: G01N33/74 , A61K31/7088 , A61K38/00 , A61K38/1875 , C07K14/51 , C07K16/22 , C12N15/1136 , C12Q1/6883 , C12Q2600/156 , C12Q2600/158 , G01N33/6887 , G01N33/6893 , G01N2333/51 , G01N2800/04 , G01N2800/22
摘要: The present invention relates to methods for diagnosing and treating iron overload and iron deficiency.
摘要翻译: 本发明涉及铁超载和铁缺乏症的诊断和治疗方法。
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