公开(公告)号：US20240190839A1

公开(公告)日：2024-06-13

申请号：US18340978

申请日：2023-06-26

Applicant: Insilico Medicine IP Limited

Inventor： Jianping Wu ,  Luoheng Qin ,  Jinxin Liu

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.

公开(公告)号：US12103915B2

公开(公告)日：2024-10-01

申请号：US18529689

申请日：2023-12-05

Applicant: Insilico Medicine IP Limited

Inventor： Xiao Ding ,  Jinxin Liu ,  Feng Ren ,  Jianfei Wan ,  Wei Zhu

IPC: C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D231/56 ,  A61P35/00 ,  C07D209/44 ,  C07D215/14 ,  C07D401/04 ,  C07D403/08 ,  C07D471/04 ,  C07D487/04

Abstract: The disclosure provides for compounds and methods for modulating or inhibiting TEAD. Further provided herein are pharmaceutical compositions comprising the TEAD inhibitors and methods of treatment using the TEAD inhibitors or the pharmaceutical compositions.

公开(公告)号：US11739077B2

公开(公告)日：2023-08-29

申请号：US18106339

申请日：2023-02-06

Applicant: Insilico Medicine IP Limited

Inventor： Jianping Wu ,  Luoheng Qin ,  Jinxin Liu

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.

公开(公告)号：US20230183210A1

公开(公告)日：2023-06-15

申请号：US18106339

申请日：2023-02-06

Applicant: Insilico Medicine IP Limited

Inventor： Jianping Wu ,  Luoheng Qin ,  Jinxin Liu

IPC: C07D401/14 ,  A61P35/00

CPC classification number: C07D401/14 ,  A61P35/00

Abstract: The disclosure provides for small molecules inhibitory compounds of ubiquitin specific protease 1 (USP1) and compositions comprising the same. The disclosure further provides methods for targeting ubiquitin specific protease 1 (USP1) and methods of treating diseases or disorders related to USP1, such as cancer.