公开(公告)号：US20160333353A1

公开(公告)日：2016-11-17

申请号：US15227832

申请日：2016-08-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanne WEIJZEN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Meriem BOURAJJAJ ,  Rick Jan VAN HAASTERT ,  Arjan Willem GRIFFIOEN ,  Judith Rosina VAN BIEJNUM ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Andreas Alphons Franciscus Ludovicus VAN PIUJENBROEK ,  Willemijn Maria GOMMANS ,  Negar BABAE ,  Petronella Innocentia VAN NOORT

IPC: C12N15/113 ,  C12N7/00 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US20170130277A1

公开(公告)日：2017-05-11

申请号：US15319452

申请日：2015-06-19

Applicant: STICHTING VU-VUMC ,  INTERNA TECHNOLOGIES B.V.

Inventor： Gerrit Albert MEIJER ,  Begoña DIOSDADO ,  Lisette M. TIMMER ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Francesco CERISOLI ,  Roeland Quirinus Jozef SCHAAPVELD

IPC: C12Q1/68

CPC classification number: C12Q1/6886 ,  C12Q2600/158 ,  C12Q2600/16 ,  C12Q2600/178

Abstract: Methods of diagnosing colorectal cancer and precursors thereof using miRNA biomarkers are disclosed, together with kits and devices for detecting the biomarkers, and uses of the biomarkers. The biomarkers described are reliably detected in stool and demonstrate significantly different expression levels in colorectal cancer patients when compared to colorectal cancer negative patients.

公开(公告)号：US20140005251A1

公开(公告)日：2014-01-02

申请号：US13933526

申请日：2013-07-02

Applicant: InteRNA Technologies B.V.

Inventor： Sanne WEIJZEN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Meriem BOURAJJAJ ,  Rick Jan VAN HAASTERT ,  Arjan Willem GRIFFIOEN ,  Judith Rosina VAN BEIJNUM ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Andreas Alphons Franciscus Ludovicus VAN PUIJENBROEK ,  Willemijn Maria GOMMANS ,  Negar BABAE ,  Petronella Innocentia VAN NOORT

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。