公开(公告)号：US20140005251A1

公开(公告)日：2014-01-02

申请号：US13933526

申请日：2013-07-02

Applicant: InteRNA Technologies B.V.

Inventor： Sanne WEIJZEN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Meriem BOURAJJAJ ,  Rick Jan VAN HAASTERT ,  Arjan Willem GRIFFIOEN ,  Judith Rosina VAN BEIJNUM ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Andreas Alphons Franciscus Ludovicus VAN PUIJENBROEK ,  Willemijn Maria GOMMANS ,  Negar BABAE ,  Petronella Innocentia VAN NOORT

IPC: C12N15/113 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US20160333353A1

公开(公告)日：2016-11-17

申请号：US15227832

申请日：2016-08-03

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Sanne WEIJZEN ,  Roeland Quirinus Jozef SCHAAPVELD ,  Meriem BOURAJJAJ ,  Rick Jan VAN HAASTERT ,  Arjan Willem GRIFFIOEN ,  Judith Rosina VAN BIEJNUM ,  Edwin Pieter Johan Gerard CUPPEN ,  Eugene BEREZIKOV ,  Andreas Alphons Franciscus Ludovicus VAN PIUJENBROEK ,  Willemijn Maria GOMMANS ,  Negar BABAE ,  Petronella Innocentia VAN NOORT

IPC: C12N15/113 ,  C12N7/00 ,  C12Q1/68

CPC classification number: C12N15/1135 ,  A61P35/00 ,  C12N7/00 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/10 ,  C12N2320/11 ,  C12N2320/30 ,  C12N2320/31 ,  C12N2710/10043 ,  C12N2740/15043 ,  C12Q1/6883 ,  C12Q1/6886

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule, an equivalent or a source thereof in a disease and condition associated with neo-angiogenesis.

Abstract translation: 本发明涉及在与新血管生成相关的疾病和病症中的miRNA分子，其等同物或来源的诊断和治疗用途。

公开(公告)号：US20160017338A1

公开(公告)日：2016-01-21

申请号：US14849777

申请日：2015-09-10

Applicant: INTERNA TECHNOLOGIES B.V.

Inventor： Roeland Quirinus Jozef SCHAAPVELD ,  Gerardus Wilhelmus Christiaan Theodoor VERHAEGH ,  Jacobus Antonius SCHALKEN ,  Andreas Alphons Franciscus Ludovicus van PUIJENBROEK ,  Willemijn Maria GOMMANS ,  Sanne WEIJZEN

IPC: C12N15/113 ,  A61K45/06 ,  A61N5/10 ,  A61K31/713

CPC classification number: C12N15/1138 ,  A61K31/7088 ,  A61K31/7105 ,  A61K31/713 ,  A61K45/06 ,  A61N5/10 ,  C12N15/113 ,  C12N2310/141 ,  C12N2320/31 ,  C12N2330/10

Abstract: The invention relates to the diagnostic and therapeutic uses of a miRNA molecule or an equivalent thereof wherein a source of said miRNA molecule or equivalent thereof comprises at least 80 nucleotides and comprises a motif having at least 98% identity with the motif represented by SEQ ID NO:1 or a source thereof in a disease and condition associated with EMT (Epithelial to Mesenchymal Transition).