专利检索 ap:("INTERNATIONAL AIDS VACCINE INITIATIVE, INC." OR "THE SCRIPPS RESEARCH INSTITUTE") AND inv:"Manyuan MA" 第 1 页

1.

发明公开
MODIFIED IMMUNOGENIC PROTEINS 审中-公开

公开(公告)号：US20230190914A1

公开(公告)日：2023-06-22

申请号：US18048960

申请日：2022-10-24

申请人： INTERNATIONAL AIDS VACCINE INITIATIVE, INC. , THE SCRIPPS RESEARCH INSTITUTE

发明人： William SCHIEF , Manyuan MA , Jon STEICHEN , Xiaozhen HU , Sebastian RAEMISCH , Alessia LIGUORI , Torben SCHIFFNER , Jordan WILLIS , Christopher COTTRELL

IPC分类号： A61K39/21 , C07K14/005 , A61P31/18

CPC分类号： A61K39/21 , A61P31/18 , C07K14/005 , A61K2039/575 , C12N2740/16022 , C12N2740/16034 , C12N2740/16071

摘要： The invention relates to germline-targeting designs, stabilization designs, and/or combinations thereof, of proteins designed with modified surfaces helpful for immunization regimens, other protein modifications and/or development of nanoparticles, methods of making and using the same, and to (a) germline-targeting priming or boosting/shepherding immunogens to initiate or guide maturation of VRC01-class responses (b) PCT64/PG9-germline-targeting designs (c) BG18-germline-targeting designs or boosting/shepherding immunogens to initiate or guide maturation of BG18-like responses, and/or (d) trimer stabilization and presentation in a membrane-bound format.