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公开(公告)号：US20240343727A1
公开(公告)日：2024-10-17
申请号：US18578677
申请日：2022-08-16
发明人： Xianhai HUANG , Younong YU , Haotao NIU , Hong YANG , Shanshan WANG , Jifang WENG , Yaolin WANG , Xing DAI
IPC分类号： C07D471/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D491/052 , C07D491/107
CPC分类号： C07D471/04 , A61K31/501 , A61K31/502 , A61K31/5025 , A61K31/506 , A61K31/5377 , A61P35/00 , C07D401/14 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/04 , C07D487/10 , C07D491/052 , C07D491/107
摘要： Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in treating cancer.
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公开(公告)号：US20230357233A1
公开(公告)日：2023-11-09
申请号：US18042872
申请日：2021-08-26
发明人： Xing DAI , Hong YANG , Xianhai HUANG , Haotao NIU , Zixing HAN , Zhenwu WANG , Qiang ZHANG , Yanqin LIU , Yueheng JIANG , Liangshan TAO , Jifang WENG , Zhe SHI , Yaolin WANG
IPC分类号： C07D471/04 , A61K45/06 , C07D519/00
CPC分类号： C07D471/04 , A61K45/06 , C07D519/00
摘要： Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (A), Formula (II), Formula (III), Formula (IV), or Formula (V), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer (e.g., non-small cell lung cancer) or endometrial cancer.
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公开(公告)号：US20240140929A1
公开(公告)日：2024-05-02
申请号：US18268681
申请日：2021-12-22
发明人： Xing DAI , Xianhai HUANG , Hong YANG , Zixing HAN , Haotao NIU , Jifang WENG , Zhe SHI , Yanqin LIU , Yueheng JIANG , Yaolin WANG
IPC分类号： C07D401/12 , C07D213/75 , C07D237/24 , C07D253/075 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
CPC分类号： C07D401/12 , C07D213/75 , C07D237/24 , C07D253/075 , C07D401/14 , C07D405/14 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04 , C07D513/04
摘要： Provided herein are novel compounds, for example, compounds having a Formula (I), or a pharmaceutically acceptable N salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting TYK2, and/or function of IL-12, IL-23 and/or INF-alpha, and/or in treating various associated diseases or disorders.
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公开(公告)号：US20230242544A1
公开(公告)日：2023-08-03
申请号：US18011138
申请日：2021-06-30
发明人： Xing DAI , Yaolin WANG , Yueheng JIANG , Haotao NIU , Yanqin LIU , Hong YANG , Zixing HAN , Zhenwu WANG , Liangshan TAO , Qiang ZHANG , Zhe SHI , Jifang WENG
IPC分类号： C07D487/08 , C07D403/12 , C07D403/14 , C07D487/04 , C07D487/10 , C07D519/00 , C07D417/14 , A61K45/06
CPC分类号： C07D487/08 , C07D403/12 , C07D403/14 , C07D487/04 , C07D487/10 , C07D519/00 , C07D417/14 , A61K45/06
摘要： Provided herein are novel compounds, for example, compounds having a Formula (I), Formula (II), or Formula (III), or a pharmaceutically acceptable salt thereof. Also provided herein are methods of preparing the compounds and methods of using the compounds, for example, in inhibiting KRASG12D in a cancer cell, and/or in treating various cancer such as pancreatic cancer, colorectal cancer, lung cancer or endometrial cancer.
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