公开(公告)号：US20210401930A1

公开(公告)日：2021-12-30

申请号：US17479101

申请日：2021-09-20

申请人： IPC Research, LLC

发明人： Charlotta Berghard ,  Magnus Berglund ,  Patrik Strömberg ,  Malin Lindborg ,  Elin Gunneriusson ,  Joachim Feldwisch

IPC分类号： A61K38/16 ,  C07K14/00 ,  A61K47/68 ,  A61K47/64 ,  C07K14/47 ,  C07K14/195 ,  C07K14/315

摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from i) EX2X3X4A X6 X7EID X11LPNL X16X17X18QW X21AFIX25X26LX28D, and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatment.

公开(公告)号：US12083160B2

公开(公告)日：2024-09-10

申请号：US17479101

申请日：2021-09-20

申请人： IPC Research, LLC

发明人： Charlotta Berghard ,  Magnus Berglund ,  Patrik Strömberg ,  Malin Lindborg ,  Elin Gunneriusson ,  Joachim Feldwisch

IPC分类号： C07K14/00 ,  A61K38/16 ,  A61K47/64 ,  A61K47/68 ,  C07K14/195 ,  C07K14/315 ,  C07K14/47 ,  C07K19/00 ,  A61K38/00

CPC分类号： A61K38/164 ,  A61K38/16 ,  A61K47/64 ,  A61K47/68 ,  A61K47/6801 ,  C07K14/00 ,  C07K14/195 ,  C07K14/315 ,  C07K14/47 ,  A61K38/00 ,  C07K2319/00 ,  C07K2319/31

摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from i) EX2X3X4A X6 X7EID X11LPNL X16X17X18QW X21AFIX25X26LX28D, and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatment.

公开(公告)号：US11123401B2

公开(公告)日：2021-09-21

申请号：US16228181

申请日：2018-12-20

申请人： IPC Research, LLC

发明人： Charlotta Berghard ,  Magnus Berglund ,  Patrik Strömberg ,  Malin Lindborg ,  Elin Gunneriusson ,  Joachim Feldwisch

IPC分类号： C07K14/00 ,  C07K19/00 ,  A61K38/16 ,  A61K47/68 ,  A61K47/64 ,  C07K14/47 ,  C07K14/195 ,  C07K14/315 ,  A61K38/00

摘要： The present invention relates to C5 binding polypeptides, comprising a C5 binding motif, BM, which motif consists of an amino acid sequence selected from i) EX2X3X4A X6 X7EID X11LPNL X16X17X18QW X21AFIX25X26LX28D, and ii) an amino acid sequence which has at least 86% identity to the sequence defined in i), wherein the polypeptide binds to C5. The present invention moreover relates to C5 binding polypeptides for use in therapy, such as for use in treatment of a C5 related condition, and to methods of treatment.