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    Tricyclic derivatives and their use as anti-cancer agents
    7.
    发明授权
    Tricyclic derivatives and their use as anti-cancer agents 失效
    三环衍生物及其作为抗癌剂的用途

    公开(公告)号：US06201129B1

    公开(公告)日：2001-03-13

    申请号：US08875667

    申请日：1997-08-01

    申请人： David Drysdale Miller ,  Patrick Vivian Richard Shannon ,  Laddawan Chuncharprasert

    发明人： David Drysdale Miller ,  Patrick Vivian Richard Shannon ,  Laddawan Chuncharprasert

    IPC分类号： C07D48704

    CPC分类号： C07D487/04

    摘要： A compound having the formula wherein R1 is COOR8 wherein R8 is alkyl having from 1 to 10 carbon atoms or aralkyl, the aralkyl having from one to four carbon atoms in the alkyl portion and a carbocyclic or heterocyclic group in the aryl portion; R2 is H, alkyl having from 1 to 10 carbon atoms, or COOR7 wherein R7 is alkyl having from 1 to 10 carbon atoms; R3 is H, alkyl having from 1 to 10 carbon atoms, or COOR8; R4 is H, alkyl having from 1 to 10 carbon atoms, or COOR8; R5 is H, alkyl having from 1 to 10 carbon atoms, aralkyl having from 1 to 4 carbon atoms in the alkyl portion, aryl having from 1 to 10 carbon atoms, acyl having from 1 to 10 carbon atoms, or COOCH3; and R6 is H or COOCH3; and thereof.

    摘要翻译： 具有式R 1的化合物是COOR 8，其中R 8是具有1至10个碳原子的烷基或芳烷基，芳烷基中具有1至4个碳原子的芳烷基和芳基部分中的碳环或杂环基; R 2是H，烷基 具有1至10个碳原子，或COOR 7，其中R 7为具有1至10个碳原子的烷基; R 3为H，具有1至10个碳原子的烷基或COOR 8; R 4为H，具有1至10个碳原子的烷基 ，或COOR 8; R 5为H，具有1至10个碳原子的烷基，烷基部分具有1至4个碳原子的芳烷基，具有1至10个碳原子的芳基，具有1至10个碳原子的酰基，或COOCH 3 ; 和R6是H或COOCH 3;及其。